ESRD ON DIALYSIS, NARCOTIC USE - Nursing Case Study
Pathophysiology
• Primary mechanism: In ESRD, kidneys lose the ability to filter waste and balance fluids and electrolytes, necessitating dialysis to perform these functions. Dialysis helps remove toxins like urea and creatinine, but patients may still experience fluid overload and electrolyte imbalances.
• Secondary mechanism: Chronic use of narcotics in ESRD patients can lead to altered drug metabolism and excretion, increasing the risk of toxicity and side effects such as respiratory depression due to the accumulation of active metabolites.
• Key complication: The combination of dialysis and narcotic use can exacerbate symptoms like hypotension and altered mental status, requiring careful monitoring and dose adjustments to maintain patient safety and comfort.
Patient Profile
Demographics:
56-year-old female, retired school teacher
History:
• Key past medical history: Hypertension, Type 2 Diabetes, End-Stage Renal Disease (ESRD) on dialysis for 2 years, Chronic back pain
• Current medications: Lisinopril, Insulin, Erythropoietin, Furosemide, Hydrocodone
• Allergies: Penicillin
Current Presentation:
• Chief complaint: Increasing fatigue and shortness of breath
• Key symptoms: Swelling in legs, decreased urine output, itching, muscle cramps, nausea
• Vital signs: Blood pressure 160/100 mmHg, Heart rate 92 bpm, Respiratory rate 22 breaths per minute, Temperature 98.6°F, Oxygen saturation 90% on room air
Section 1
The initial assessment of the patient reveals several concerning findings that align with her current presentation of increasing fatigue and shortness of breath. Upon physical examination, the nurse notes significant pitting edema in both legs, indicating fluid overload, a common issue in patients with ESRD on dialysis. The patient's lung auscultation reveals bilateral crackles, suggesting pulmonary congestion, potentially due to fluid accumulation. Her skin appears dry and exhibits excoriation marks from scratching, likely caused by pruritus related to elevated phosphorus levels. Additionally, the patient reports persistent muscle cramps and nausea, which may be indicative of electrolyte imbalances, particularly concerning potassium levels.
These clinical findings prompt further diagnostic evaluation to ascertain the underlying causes of her symptoms. Recent lab results show elevated potassium at 6.2 mEq/L, well above the normal range, posing a risk for cardiac arrhythmias. Blood urea nitrogen (BUN) and creatinine levels are also elevated, indicating inadequate clearance despite dialysis. Hemoglobin levels are low, at 9.5 g/dL, which may contribute to her fatigue and shortness of breath due to anemia commonly associated with renal disease. The patient's hydrocodone use is reviewed, and her current dosage is considered potentially excessive given her renal impairment, raising concerns about narcotic accumulation and respiratory depression, as evidenced by her low oxygen saturation.
The healthcare team decides to adjust the patient's dialysis schedule and intensity to address the fluid overload and electrolyte imbalance, while also considering a review of her pain management regimen to mitigate the risk of narcotic-related complications. The nurse educates the patient on the importance of adhering to dietary restrictions, particularly potassium and phosphorus intake, and the necessity of regular follow-up appointments to monitor her condition closely. This comprehensive approach aims to stabilize her condition and prevent further complications, emphasizing the need for ongoing monitoring and collaboration between the patient and healthcare providers.
Section 2
Several days after adjusting her dialysis schedule and reviewing her pain management regimen, the patient returns for a follow-up evaluation. Upon arrival, she expresses feeling somewhat less fatigued but reports persistent shortness of breath and occasional dizziness. The nurse immediately conducts a thorough assessment. Vital signs reveal a blood pressure of 150/95 mmHg, heart rate of 92 beats per minute, respiratory rate of 22 breaths per minute, and an oxygen saturation of 88% on room air, indicating continued respiratory compromise. The physical examination shows persistent bilateral pitting edema, now extending to her thighs, and auscultation of her lungs reveals worsened crackles throughout both lung fields. This suggests that the fluid overload has not been adequately resolved, and there may be an ongoing issue with her dialysis adequacy or patient compliance with fluid restrictions.
Given these findings, the healthcare team orders repeat laboratory tests to determine the current status of her electrolytes and renal function. Her potassium level remains elevated at 5.9 mEq/L, and her BUN and creatinine levels show only slight improvement, at 75 mg/dL and 9.0 mg/dL respectively, suggesting insufficient removal of waste products. Her hemoglobin has decreased further to 8.8 g/dL, exacerbating her anemia and contributing to her symptoms of dizziness and weakness. The team also notes a slight increase in her white blood cell count, prompting consideration of potential infection, which could be a complicating factor given her immunocompromised state.
In response to these developments, the care team decides to intensify her dialysis regimen once again and consults with a nephrologist to explore potential adjustments in her dialysis prescription, including the possibility of altering the dialysate composition. They also discuss with the patient the critical importance of adhering to fluid and dietary restrictions, emphasizing the need to limit potassium and phosphorus intake rigorously. Additionally, a referral to a dietitian is made to provide further education and support in managing her dietary needs effectively. The team plans to monitor her closely for any signs of infection and consider erythropoiesis-stimulating agents to address her anemia if necessary, aiming to stabilize her condition and prevent further complications.
Section 3
Following the intensified dialysis regimen and ongoing dietary education, the patient returns for another follow-up visit one week later. Upon initial assessment, the nurse notes a slight improvement in her respiratory status, with an oxygen saturation of 90% on room air, though it remains below the normal range. Her respiratory rate has decreased to 20 breaths per minute, and her crackles, though still present, have diminished slightly. However, the patient reports new symptoms of intermittent palpitations and an increased frequency of muscle cramps, particularly at night. Her blood pressure is recorded at 145/92 mmHg, and her heart rate has risen to 98 beats per minute with occasional irregularities noted upon auscultation.
The latest laboratory results reveal that her potassium level has decreased slightly to 5.5 mEq/L but remains elevated. Her calcium level is noted to be low at 8.0 mg/dL, and her phosphorus level is high at 6.0 mg/dL, indicating ongoing issues with mineral metabolism balance. The patient's BUN and creatinine levels show minimal changes, with BUN at 72 mg/dL and creatinine at 8.7 mg/dL. These findings suggest that while the adjustment in her dialysis regimen has had some effect, further optimization is necessary. The patient's hemoglobin level has stabilized at 8.9 g/dL, but it is still indicative of anemia.
In response to these developments, the healthcare team decides to further adjust the patient's dialysis prescription, possibly increasing the frequency or duration of sessions. A cardiology consult is also requested to evaluate her palpitations and potential cardiac involvement, given her electrolyte imbalances and underlying conditions. The team considers initiating calcium supplements and revisiting her phosphate binder prescription to address the mineral imbalances. The dietitian continues to work closely with the patient to reinforce dietary modifications that can effectively manage her electrolyte levels. As these interventions are put into place, the team remains vigilant, monitoring for any signs of cardiac complications or further deterioration in her overall status.
Section 4
As the healthcare team continues to implement the adjusted interventions, the patient returns for another follow-up visit two weeks later. During the initial assessment, the nurse notes that the patient's respiratory status has improved further, with an oxygen saturation now at 92% on room air. Her respiratory rate has stabilized at 18 breaths per minute, and the crackles are barely audible upon auscultation. However, the patient reports persistent palpitations, now accompanied by occasional dizziness and fatigue. Her blood pressure remains elevated at 148/94 mmHg, and her heart rate is irregular, fluctuating between 95 and 110 beats per minute.
The latest laboratory results show a potassium level that has decreased further to 5.2 mEq/L, approaching the upper limit of normal, while her calcium level has improved to 8.5 mg/dL with the initiation of supplements. Her phosphorus level remains elevated at 5.8 mg/dL, indicating a need for continued adjustment of her phosphate binder regimen. The patient's hemoglobin level has increased slightly to 9.1 g/dL, suggesting a positive response to anemia management strategies. Despite these improvements, her BUN and creatinine levels remain largely unchanged, with BUN at 70 mg/dL and creatinine at 8.5 mg/dL.
In response to these findings, the cardiologist recommends the initiation of a beta-blocker to help manage the patient's palpitations and irregular heart rate, alongside closer monitoring of her cardiac status. The healthcare team decides to continue with the current dialysis regimen, while the dietitian intensifies dietary guidance to focus on phosphorus control. These strategies aim to stabilize her condition and prevent further complications, while the team remains attentive to any signs of cardiac or renal deterioration that may necessitate additional interventions.
Section 5
Two weeks after the implementation of the new interventions, the patient presents for another follow-up visit. Upon arrival, she appears more fatigued than during previous visits and is slightly short of breath. During the initial assessment, her oxygen saturation is stable at 91% on room air. However, her blood pressure has risen to 158/96 mmHg, and her heart rate has increased slightly, now fluctuating between 98 and 112 beats per minute. The nurse notes that the patient’s irregular heart rhythm persists, and she reports an increase in the frequency of her palpitations and dizziness episodes. Auscultation reveals a reemergence of faint crackles in the lower lung fields, suggesting a potential fluid overload issue.
The latest laboratory results reveal a concerning trend: her potassium level has unexpectedly increased to 5.8 mEq/L, exceeding the normal range, while her phosphorus remains elevated at 6.2 mg/dL, despite intensified dietary measures. Her calcium level has stabilized at 8.6 mg/dL, and her hemoglobin has not improved further, remaining at 9.1 g/dL. The BUN and creatinine levels show no significant change, with BUN at 72 mg/dL and creatinine at 8.6 mg/dL. These findings suggest that despite some initial improvements, the patient's overall status is not stabilizing as anticipated, and new complications are emerging.
Given these developments, the healthcare team is prompted to reassess the current treatment plan. The increase in potassium levels raises concerns about potential hyperkalemia, which, coupled with the patient's cardiac irregularities, necessitates immediate attention. The team considers adjusting the patient's medication regimen, possibly revisiting the use of potassium binders and reevaluating the dialysis schedule to better manage electrolyte levels. At the same time, the cardiologist recommends further cardiac evaluation to rule out any underlying arrhythmias that may be contributing to her symptoms. As the team formulates a revised plan, they remain vigilant for any signs of cardiac or renal deterioration, understanding that these complications could significantly impact the patient's overall prognosis.