Diabetes - Nursing Case Study

Pathophysiology

• Primary mechanism: Insulin deficiency or resistance leads to hyperglycemia. In Type 1 Diabetes, autoimmune destruction of pancreatic beta cells results in insufficient insulin production. In Type 2 Diabetes, cells become resistant to insulin's effects, impairing glucose uptake.

• Secondary mechanism: Impaired cellular glucose uptake triggers compensatory hyperinsulinemia in Type 2 Diabetes, which can eventually exhaust beta cells, further reducing insulin secretion and exacerbating hyperglycemia.

• Key complication: Chronic hyperglycemia causes damage to blood vessels, leading to complications such as neuropathy, nephropathy, and retinopathy, significantly impacting patient quality of life and increasing morbidity.

Patient Profile

Demographics:

58-year-old male, office manager

History:

• Key past medical history: Type 2 Diabetes diagnosed 8 years ago, hypertension, hyperlipidemia

• Current medications: Metformin 1000 mg BID, Lisinopril 20 mg daily, Atorvastatin 40 mg daily, Aspirin 81 mg daily

• Allergies: Sulfa drugs

Current Presentation:

• Chief complaint: Increasing fatigue and blurred vision

• Key symptoms: Numbness in feet, frequent urination, unintentional weight loss, occasional dizziness

• Vital signs: Blood pressure 145/90 mmHg, heart rate 88 bpm, respiratory rate 18 breaths per minute, temperature 98.6°F, blood glucose 220 mg/dL

Section 1

Following the initial assessment of the 58-year-old male with type 2 diabetes, the healthcare team notes several concerning findings that suggest the development of diabetic neuropathy, a complication associated with chronic hyperglycemia. The patient's numbness in his feet is accompanied by decreased vibratory sensation and diminished ankle reflexes, indicating peripheral nerve damage. Additionally, the blurred vision he experiences may signify the onset of diabetic retinopathy, necessitating an urgent ophthalmologic examination to assess the extent of retinal changes. Clinically, his elevated blood glucose level of 220 mg/dL reflects poor glycemic control, a critical factor in the progression of diabetic complications.

Routine laboratory tests reveal a hemoglobin A1c level of 9.2%, significantly higher than the recommended target of less than 7%, indicating chronic poor blood sugar management over the past three months. Additionally, a urine microalbumin test shows elevated levels, suggesting early nephropathy. His kidney function tests reveal a slightly elevated serum creatinine level of 1.4 mg/dL, pushing the need for nephrology referral and potential adjustment of his current medications to preserve renal function. These findings underscore the importance of tighter glucose regulation and a multidisciplinary approach to mitigate further complications.

The healthcare team recognizes the need for an interdisciplinary intervention, involving an endocrinologist for possible initiation of insulin therapy to improve glycemic control and a dietitian to provide tailored nutritional advice. Patient education will focus on the importance of medication adherence, lifestyle modifications, and regular monitoring of blood glucose levels. This comprehensive strategy aims to prevent further progression of diabetes-related complications and enhance the patient's quality of life. This approach sets the stage for reassessment and potential adjustments in the management plan, emphasizing the dynamic nature of chronic disease management.

Section 2

Following the implementation of the interdisciplinary intervention, the healthcare team conducts a follow-up assessment to evaluate the patient's response to the newly initiated insulin therapy and dietary modifications. Over the course of four weeks, the patient exhibits moderate improvement in glycemic control as evidenced by a reduction in his fasting blood glucose levels, which now average between 140-160 mg/dL. Although this is still above the ideal target, it demonstrates progress from the initial 220 mg/dL. Moreover, the patient reports increased adherence to his medication regimen and dietary plan, facilitated by his sessions with the dietitian, where he learned to incorporate low-glycemic-index foods and manage portion sizes more effectively.

Despite these improvements, new diagnostic results raise additional concerns. A follow-up ophthalmologic examination reveals early-stage proliferative diabetic retinopathy, characterized by the formation of new, fragile blood vessels on the retina. This finding necessitates further intervention, potentially including laser therapy or anti-VEGF injections, to prevent progression to vision-threatening complications. Concurrently, recent laboratory tests show a slight increase in urine microalbumin levels, indicating a progression of nephropathy despite efforts to optimize blood pressure and glucose control. The patient's blood pressure remains stable at 130/85 mmHg, but given the renal findings, his nephrologist considers introducing an ACE inhibitor to further protect kidney function.

These developments highlight the complexity of managing diabetes and its complications, emphasizing the need for ongoing monitoring and timely adjustments to the care plan. The healthcare team must continue to employ clinical reasoning to balance the management of existing conditions while preventing new complications. The patient agrees to more frequent follow-ups, recognizing the importance of early detection and intervention in preserving his health and quality of life. The next phase of his care will focus on reassessing his therapeutic regimen's efficacy and exploring additional strategies to address both neuropathic and retinopathic challenges, while monitoring for any further renal impairment.

Section 3

After the healthcare team implements the proposed interventions, including the initiation of an ACE inhibitor to mitigate renal complications and regular ophthalmologic follow-ups, the patient returns for a routine assessment. During this visit, the nurse notes that the patient has gained a better understanding of his condition and expresses a strong commitment to managing his diabetes. However, the patient mentions experiencing intermittent numbness and tingling in his feet, raising concerns about potential neuropathy. Upon further examination, the nurse observes diminished sensation in the lower extremities using a monofilament test, indicating early signs of peripheral neuropathy.

Laboratory results obtained during this visit reveal that the patient's HbA1c level has decreased to 7.8% from the initial 9.5%, reflecting an overall improvement in glycemic control. Despite this progress, the slight increase in urine microalbumin persists, with current levels at 40 mg/g creatinine, which is above the normal range but stable compared to previous readings. The patient’s blood pressure remains steady at 128/82 mmHg, showing an effective response to the ACE inhibitor.

Given these findings, the healthcare team discusses the importance of enhancing the patient's neuropathy management plan. They introduce strategies such as increased emphasis on foot care education, including daily checks for injury or infection, as well as considering medications like gabapentin for symptomatic relief. The team also reinforces the need for continued interprofessional collaboration, suggesting regular visits with a podiatrist to prevent further complications. These measures aim to address the new onset of neuropathy while maintaining focus on the existing retinopathy and nephropathy, ensuring a comprehensive approach to the patient's diabetes management. As the patient leaves the clinic, he is scheduled for a follow-up in six weeks to reassess and adjust his care plan as necessary, ensuring the best possible outcomes in his ongoing journey with diabetes.

Section 4

Six weeks later, the patient returns to the clinic for his scheduled follow-up. During the initial assessment, the nurse notes that the patient appears more confident and expresses satisfaction with his progress in managing diabetes. However, he reports increased occurrences of numbness and tingling, now affecting his hands in addition to his feet. This new symptom prompts concern for the possible progression of neuropathy. The nurse performs a thorough neurovascular assessment, revealing further diminished sensation in both the upper and lower extremities using a monofilament test. The patient's pedal pulses remain palpable but are slightly weaker than during the previous visit, indicating potential peripheral vascular involvement.

Laboratory results reveal that the patient's HbA1c has further improved to 7.5%, demonstrating continued success in glycemic control. However, there is a slight increase in urine microalbumin to 45 mg/g creatinine, suggesting that renal function requires closer monitoring, despite the ongoing use of an ACE inhibitor. The patient's blood pressure remains well-controlled at 126/80 mmHg, indicating continued cardiovascular stability.

In response to these findings, the healthcare team discusses augmenting the patient's management plan to address the progression of neuropathy and the slight worsening of nephropathy. They reinforce the importance of strict blood glucose control and emphasize more aggressive foot care, recommending daily checks and moisturizing to prevent skin breakdown. The team considers adjusting the patient's medication regimen to include an increased dose of gabapentin for neuropathic pain and discusses the possibility of adding a sodium-glucose co-transporter-2 (SGLT2) inhibitor to provide additional renal protection. The patient is educated about these changes and reminded of the importance of maintaining regular appointments with both his primary care provider and specialists, including an endocrinologist and nephrologist, to ensure comprehensive diabetes management. The team schedules another follow-up in six weeks to evaluate the effectiveness of these interventions and make further adjustments as necessary.

Section 5

Six weeks later, the patient returns for his follow-up appointment, eager to share his experiences since the medication adjustments. During the initial assessment, the nurse notes that while the patient reports a reduction in neuropathic pain due to the increased dose of gabapentin, he has begun experiencing episodes of dizziness, particularly upon standing. This prompts the nurse to consider possible orthostatic hypotension, a known side effect of both gabapentin and the SGLT2 inhibitor, which was recently added to his regimen. Vital signs reveal a blood pressure of 118/76 mmHg when seated and a drop to 104/68 mmHg upon standing, confirming the suspicion of orthostatic changes.

Laboratory results from this visit show a continued improvement in HbA1c, now at 7.2%, reflecting sustained glycemic control. However, the urine microalbumin level has increased slightly to 50 mg/g creatinine, raising concerns about the ongoing progression of nephropathy. The patient's estimated glomerular filtration rate (eGFR) has decreased to 58 mL/min/1.73 m², suggesting mild renal impairment. These findings necessitate a reassessment of the patient's medication regimen and close monitoring of renal function.

In light of these developments, the healthcare team decides to adjust the patient's treatment plan. They opt to lower the dose of the SGLT2 inhibitor to mitigate the risk of orthostatic hypotension while maintaining its renal protective benefits. The patient is advised to increase fluid intake and rise slowly from sitting or lying positions to manage dizziness. The team emphasizes the importance of continued adherence to lifestyle modifications and scheduled follow-ups with the nephrologist to closely monitor renal function and prevent further deterioration. The patient is scheduled for a follow-up in four weeks to assess the impact of these changes and ensure stability in his overall condition.