Diabetes - Nursing Case Study
Pathophysiology
• Primary mechanism: In type 1 diabetes, the immune system mistakenly attacks and destroys insulin-producing beta cells in the pancreas, leading to an absolute insulin deficiency and elevated blood glucose levels.
• Secondary mechanism: In type 2 diabetes, insulin resistance occurs, where cells in muscles, fat, and the liver do not respond effectively to insulin, coupled with a progressive decline in insulin production, resulting in hyperglycemia.
• Key complication: Chronic hyperglycemia can lead to microvascular complications, such as diabetic retinopathy, nephropathy, and neuropathy, due to damage to small blood vessels, impacting vision, kidney function, and nerve health.
Patient Profile
Demographics:
56-year-old male, office manager
History:
• Key past medical history: Type 2 Diabetes diagnosed 8 years ago, hypertension, hyperlipidemia
• Current medications: Metformin 1000 mg twice daily, Lisinopril 20 mg daily, Atorvastatin 40 mg daily, Aspirin 81 mg daily
• Allergies: Penicillin
Current Presentation:
• Chief complaint: Increasing fatigue and episodes of blurred vision
• Key symptoms: Numbness in feet, frequent urination, excessive thirst, slow-healing foot ulcer
• Vital signs: Blood pressure 150/95 mmHg, heart rate 88 bpm, respiratory rate 20 breaths per minute, temperature 98.6°F, blood glucose level 210 mg/dL
Section 1
New Diagnostic Results:
During the follow-up appointment, further diagnostic tests were conducted to assess the extent of the complications associated with the patient's type 2 diabetes. A comprehensive metabolic panel revealed a serum creatinine level of 1.8 mg/dL, indicating declining kidney function suggestive of early diabetic nephropathy. Additionally, a lipid panel showed LDL cholesterol at 160 mg/dL, HDL cholesterol at 38 mg/dL, and triglycerides at 210 mg/dL, confirming poorly controlled hyperlipidemia despite current statin therapy. The patient's HbA1c level was measured at 9.2%, reflecting suboptimal glycemic control over the past three months.
An ophthalmologic exam was performed due to the patient's complaints of blurred vision, revealing moderate non-proliferative diabetic retinopathy with microaneurysms and cotton wool spots in both eyes. The findings suggest microvascular damage, likely exacerbated by persistent hyperglycemia and hypertension. Furthermore, a monofilament test indicated reduced sensation in the feet, consistent with peripheral neuropathy, contributing to the slow-healing ulcer on the patient's right foot.
These diagnostic results underscore the need for a more aggressive management approach, integrating tighter glycemic control, adjustments in antihypertensive and lipid-lowering therapy, and further interventions to prevent progression of retinopathy and nephropathy. The healthcare team must consider increasing the patient's metformin dosage or adding another oral hypoglycemic agent or insulin therapy. It will also be crucial to enhance patient education on lifestyle modifications, including dietary changes and regular physical activity, to address both blood sugar control and cardiovascular risk. These steps are vital to mitigate further complications and improve the patient's overall prognosis.
Section 2
Change in Patient Status:
Several weeks after the implementation of the revised management plan, the patient returned for a follow-up visit. During this visit, the patient reported experiencing increased fatigue and occasional dizziness, particularly when rising from a seated position. A comprehensive assessment was performed, revealing postural hypotension with a blood pressure reading of 120/80 mmHg when seated, which dropped to 100/60 mmHg upon standing. The patient's resting heart rate was recorded at 88 beats per minute. A review of the patient's medication regimen indicated that the recent increase in the dosage of the ACE inhibitor might be contributing to the patient's symptoms.
In addition to these findings, the patient's blood glucose levels, as measured by self-monitoring, showed persistent hyperglycemia with fasting glucose levels averaging around 180 mg/dL. Despite the addition of a new oral hypoglycemic agent, the patient's HbA1c had only marginally decreased to 8.8%, highlighting the need for further adjustments in the diabetes management plan. The slow-healing ulcer on the patient's right foot had shown some improvement, though it remained a concern, necessitating continued wound care and monitoring for signs of infection.
These changes in the patient's status prompted the healthcare team to reevaluate the current treatment strategy. There was a consideration to adjust the antihypertensive regimen to mitigate the symptoms of postural hypotension, possibly by reducing the ACE inhibitor dosage or exploring alternative options. Furthermore, the team discussed the potential initiation of insulin therapy to achieve better glycemic control. Emphasis was placed on reinforcing the importance of lifestyle modifications, particularly focusing on dietary adherence and increasing physical activity, to support the pharmacological interventions and prevent further complications. This approach aimed to stabilize the patient's condition and improve overall quality of life, while also setting the stage for subsequent evaluations and modifications as needed.
Section 3
Response to Interventions:
Following the reevaluation of the patient's treatment plan, the healthcare team decided to reduce the dosage of the ACE inhibitor and introduce a low-dose beta-blocker to better manage the patient's blood pressure and alleviate symptoms of postural hypotension. Over the next few weeks, the patient reported a decrease in dizziness, particularly when transitioning from sitting to standing positions. Blood pressure readings stabilized, with seated measurements averaging 118/78 mmHg and standing measurements improving to 112/74 mmHg. The patient's heart rate also showed a slight decrease to 80 beats per minute, indicating an improved cardiovascular response.
Despite these improvements, the patient continued to experience challenges with blood glucose control. The initiation of a basal insulin regimen was considered necessary, given the persistent hyperglycemia and marginal improvement in HbA1c levels. The patient was started on a low dose of long-acting insulin, with careful titration planned based on self-monitored blood glucose levels. Initial follow-up data showed a reduction in fasting glucose levels to an average of 150 mg/dL, indicating a positive response to insulin therapy. However, the healthcare team remained vigilant, closely monitoring for any signs of hypoglycemia and adjusting the insulin dose accordingly.
In parallel, the slow-healing ulcer on the patient's right foot demanded continued attention. The wound care team implemented advanced dressing techniques and emphasized the importance of offloading pressure from the affected area. Weekly assessments showed gradual healing progress, with no signs of infection. This multifaceted approach, combining pharmacological adjustments, lifestyle interventions, and diligent wound care, underscored the necessity for a holistic management plan to address the patient's evolving needs. As the patient navigated these changes, the healthcare team prepared to evaluate the next steps, including potential adjustments to insulin therapy and further lifestyle modifications, to sustain improvements and prevent new complications.
Section 4
Several weeks into the updated treatment regimen, the patient began to report new symptoms, including increased fatigue and mild tingling in the fingers and toes. Concerned about these developments, the healthcare team conducted a thorough assessment to explore potential underlying causes. Neurological examination revealed diminished vibratory sensation and decreased ankle reflexes, suggestive of peripheral neuropathy, a common complication in diabetes. The patient's recent lab results showed a further reduction in HbA1c to 8.2%, indicating some improvement, but still above the target range. Fasting glucose levels had stabilized around 140 mg/dL, but occasional postprandial spikes were observed, necessitating further investigation.
The team ordered a comprehensive metabolic panel and a complete blood count to rule out other causes of the patient's fatigue and paresthesia. Results were notable for a slightly elevated serum creatinine level at 1.4 mg/dL, suggesting potential early kidney involvement, and a marginally reduced hematocrit at 38%, raising concerns about anemia. Closer examination revealed mild microalbuminuria, prompting the healthcare team to intensify their focus on renal protection and reconsider the current antihypertensive strategy.
Given these findings, the healthcare team decided to enhance patient education on glycemic control and dietary adjustments while optimizing insulin therapy to mitigate blood glucose fluctuations. In addition, an increase in the ACE inhibitor dosage was considered to better address nephropathy, with close monitoring planned to avoid exacerbating postural hypotension. These developments highlighted the intricate balance required in managing diabetes with emerging complications, emphasizing the need for a patient-centered approach. As the patient and the healthcare team prepared to address these new challenges, they remained committed to preventing further progression and ensuring the patient's overall well-being.
Section 5
Following the updated treatment plan, the patient was closely monitored for any changes in symptoms or new complications. Over the next few weeks, the patient began to experience increased episodes of dizziness, particularly when moving from sitting to standing positions, along with persistent fatigue. A follow-up assessment was conducted, incorporating a comprehensive review of the patient's current medications, lifestyle, and dietary habits. The patient's blood pressure, recorded at 105/68 mmHg while seated, dropped to 88/60 mmHg upon standing, confirming signs of orthostatic hypotension. This development was particularly concerning given the recent increase in ACE inhibitor dosage aimed at protecting renal function.
In light of the patient's orthostatic hypotension, the healthcare team decided to reassess the antihypertensive regimen. Consideration was given to adjusting the ACE inhibitor dosage or possibly incorporating a different class of antihypertensives that might better manage blood pressure without contributing to the patient's hypotensive episodes. Alongside medication adjustments, the patient received education on non-pharmacological strategies to manage orthostatic symptoms, such as maintaining adequate hydration, rising slowly from seated or lying positions, and using compression stockings if necessary.
Meanwhile, the patient's lab results continued to be monitored. An updated complete blood count revealed a further decrease in hematocrit to 36%, suggesting a worsening of anemia. The team initiated an investigation into potential causes, including nutritional deficiencies or chronic disease anemia, and considered the possibility of further renal impairment contributing to the anemia. As the healthcare team worked to stabilize the patient's condition, they remained vigilant in monitoring for any additional complications, understanding the interconnected nature of diabetes management and its potential impact on the patient's overall health. These findings underscored the need for a tailored, dynamic approach to care, ensuring that the patient's treatment plan evolved in tandem with their changing health status.