Hyppertension - Nursing Case Study

Pathophysiology

• Primary mechanism: Increased peripheral vascular resistance due to endothelial dysfunction, often from factors like chronic inflammation or oxidative stress, leads to sustained high blood pressure as blood flow meets resistance in the narrowed vessels.

• Secondary mechanism: Enhanced activity of the renin-angiotensin-aldosterone system (RAAS) results in vasoconstriction and sodium retention, further elevating blood pressure by increasing blood volume and systemic vascular resistance.

• Key complication: Prolonged hypertension can lead to damage of vital organs, particularly the heart, kidneys, and brain, increasing the risk of heart failure, renal impairment, and stroke.

Patient Profile

Demographics:

56, male, construction worker

History:

• Key past medical history: Hypertension diagnosed 5 years ago, borderline type 2 diabetes, mild hyperlipidemia

• Current medications: Lisinopril 20 mg daily, Metformin 500 mg twice daily, Atorvastatin 10 mg daily

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Persistent headache and occasional dizziness

• Key symptoms: Fatigue, blurred vision, shortness of breath on exertion

• Vital signs: Blood pressure 160/98 mmHg, heart rate 88 bpm, respiratory rate 18 breaths per minute, temperature 98.6°F

Section 1

New Diagnostic Results:

Following the initial assessment, the healthcare team ordered a series of diagnostic tests to evaluate the extent of target organ damage due to the patient's poorly controlled hypertension and other underlying conditions. The lab results revealed elevated serum creatinine levels at 1.8 mg/dL, indicating potential renal impairment, with a glomerular filtration rate (GFR) of 55 mL/min/1.73 m², classifying the patient in Stage 3 chronic kidney disease. Additionally, a fasting blood glucose test displayed a level of 145 mg/dL, confirming poor glycemic control, while a lipid profile showed LDL cholesterol at 160 mg/dL, suggesting that hyperlipidemia remains suboptimally managed.

An electrocardiogram (ECG) was performed, which revealed left ventricular hypertrophy, a common cardiac adaptation to long-standing hypertension, which suggests that the heart is working harder than normal to pump blood against the elevated systemic vascular resistance. The echocardiogram further supported these findings by showing evidence of mild diastolic dysfunction, a precursor to heart failure, indicating that the heart's ability to relax and fill properly is becoming compromised.

These diagnostic results underscore the need for a comprehensive review and adjustment of the patient's treatment plan. The construction worker's current regimen may require intensification, such as increasing the dose of Lisinopril or adding another antihypertensive agent to better control blood pressure and protect renal function. Additionally, addressing lifestyle factors such as diet, exercise, and weight management will be crucial to improving overall cardiovascular health and preventing further progression of complications. The healthcare team must prioritize multidisciplinary care, engaging a dietitian and possibly a diabetes educator, to provide targeted interventions that address both the hypertension and borderline diabetes, as well as the mild hyperlipidemia.

Section 2

Change in Patient Status:

Several weeks after the adjustment of her treatment plan, the patient returned for a follow-up visit. During this period, her antihypertensive regimen had been modified to include an increased dose of Lisinopril, with the addition of Amlodipine, a calcium channel blocker, to better control her blood pressure. Moreover, she had been working with a dietitian to adopt a heart-healthy diet and had started a moderate exercise routine. Despite these efforts, the patient's blood pressure during this visit remained elevated at 160/95 mmHg, indicating that her hypertension was still suboptimally managed.

Further evaluation revealed a troubling change in her renal function. Her latest laboratory tests showed an increase in serum creatinine to 2.1 mg/dL, with a corresponding decrease in GFR to 48 mL/min/1.73 m², suggesting progression to Stage 3b chronic kidney disease. These findings raised concerns about the adequacy of her current treatment strategy and the potential need for more aggressive management. Additionally, the patient's fasting blood glucose levels remained elevated, hovering around 150 mg/dL, despite dietary modifications, indicating persistent poor glycemic control.

Clinically, the patient reported increased fatigue and occasional episodes of shortness of breath on exertion, suggestive of worsening cardiac function. Given the persistence of elevated blood pressure and the progression of renal impairment, the healthcare team considered the introduction of a diuretic to manage fluid overload and further protect renal function. This change in patient status underscored the need for ongoing monitoring and potential referral to a nephrologist and cardiologist to address the complex interplay of her comorbid conditions. The team emphasized the importance of medication adherence, lifestyle changes, and regular follow-up appointments to mitigate the risk of further complications.

Section 3

Following the introduction of a diuretic to the patient's regimen, there was a notable shift in her clinical status during a subsequent follow-up visit. The patient's blood pressure showed a modest improvement, now measuring at 150/90 mmHg, but still not at the optimal target. However, the addition of the diuretic seemed to have a positive impact on her symptoms of fluid overload; she reported a reduction in shortness of breath and a slight increase in energy levels. Despite these improvements, the clinical team remained concerned about her renal function, as her serum creatinine had further increased to 2.3 mg/dL, and her GFR had declined to 45 mL/min/1.73 m². These laboratory findings indicated a continued deterioration of her kidney function, necessitating close monitoring and potential adjustment of her treatment plan.

In addition to monitoring her renal function, the team conducted a more comprehensive cardiovascular assessment. An echocardiogram revealed mild left ventricular hypertrophy, a common consequence of long-standing hypertension, which could be contributing to her cardiac symptoms. This finding emphasized the need for more aggressive blood pressure control to prevent further cardiac remodeling and potential progression to heart failure. Given the persistent elevation in blood pressure and the new cardiovascular findings, the team contemplated the possibility of adding a beta-blocker to help manage both her hypertension and cardiac workload.

The patient was counseled on the importance of strict adherence to her medication regimen and lifestyle modifications. The healthcare team discussed the potential benefits of further dietary adjustments, possibly incorporating a low-sodium diet to aid in managing her blood pressure and fluid status. They also scheduled a referral to a nephrologist to provide specialized care for her advancing kidney disease and consider additional interventions that might preserve renal function. This comprehensive approach aimed to address the multifaceted nature of her condition and prevent the onset of more severe complications.

Section 4

Two weeks after the introduction of the beta-blocker to the patient's regimen, the clinical team conducted a follow-up visit to assess her response to the intervention. During this visit, the patient reported feeling more fatigued than usual and experiencing episodes of dizziness, particularly upon standing. Her blood pressure had decreased further to 138/85 mmHg, indicating an improvement towards target levels. However, her heart rate was noted to be bradycardic at 54 beats per minute, suggesting a potential adverse effect of the beta-blocker.

Laboratory tests showed that her serum creatinine had increased slightly to 2.5 mg/dL, and her GFR had further declined to 40 mL/min/1.73 m². These results continued to reflect a worsening renal function, which raised concerns about whether the current medication regimen was exacerbating her kidney issues. The patient’s potassium levels were also elevated at 5.5 mEq/L, possibly indicating an imbalance related to her diuretic use or declining kidney function.

Given these findings, the healthcare team faced a critical decision: how to balance the benefits of blood pressure and cardiac workload reduction with the need to stabilize her renal function and manage side effects. They discussed the possibility of adjusting the dosage of her medications or exploring alternative antihypertensive agents that might be less impactful on her renal status. The team emphasized the importance of monitoring her symptoms closely and maintaining regular follow-up appointments to quickly identify and address any further complications. This nuanced approach underscored the need for careful clinical reasoning to optimize her treatment plan and address the interconnected nature of her cardiovascular and renal conditions.

Section 5

Two weeks after the clinical team adjusted the patient's medication regimen by reducing the dosage of the beta-blocker and introducing an ACE inhibitor to better protect her renal function, the patient returned for another follow-up appointment. During this visit, she reported that her fatigue had slightly improved, but she continued to experience occasional dizziness. Importantly, her blood pressure was now 135/82 mmHg, a further improvement in controlling her hypertension. However, her heart rate remained bradycardic at 56 beats per minute, and the team noted the persistence of renal function concerns.

New laboratory results indicated that her serum creatinine level had stabilized at 2.4 mg/dL, and her GFR had improved marginally to 42 mL/min/1.73 m². Despite these slight improvements, her potassium level remained elevated at 5.4 mEq/L, necessitating close monitoring to prevent hyperkalemia-related complications. The team also discovered a new development: the patient’s hemoglobin level had decreased to 10.5 g/dL, which could suggest the onset of anemia, potentially linked to her chronic kidney disease.

Given these mixed results, the healthcare team focused on refining her treatment strategy. They discussed the potential benefits of adding a potassium binder to manage her hyperkalemia and considered the introduction of erythropoiesis-stimulating agents to address her anemia. The team recognized the complexity of her condition and the necessity for a multidisciplinary approach, involving a nephrologist and a cardiologist, to ensure comprehensive care. They emphasized the importance of patient education, encouraging her to report any new or worsening symptoms promptly and adhere to her follow-up schedule to facilitate timely interventions.