kidney stones - Nursing Case Study
Pathophysiology
• Primary mechanism: Supersaturation of urine with stone-forming salts, such as calcium, oxalate, uric acid, or cystine, leads to their precipitation and crystallization, forming the initial nidus for stone development. High urinary concentration, low fluid intake, and certain dietary factors can exacerbate this process.
• Secondary mechanism: Deficiency of natural inhibitors in the urine, such as citrate and magnesium, which normally prevent crystal aggregation and stone formation. When these inhibitors are low, crystals can stick together, growing larger and potentially forming obstructive stones.
• Key complication: Stones can obstruct urine flow, leading to hydronephrosis or infection. Additionally, the movement of stones can cause severe pain (renal colic) and hematuria, significantly affecting patient quality of life and requiring prompt medical management.
Patient Profile
Demographics:
45-year-old male, construction worker
History:
• Key past medical history: History of recurrent urinary tract infections, hypertension
• Current medications: Lisinopril 10 mg daily, ibuprofen as needed
• Allergies: Penicillin
Current Presentation:
• Chief complaint: Severe flank pain radiating to the groin
• Key symptoms: Nausea, hematuria, difficulty urinating, fever
• Vital signs: Blood pressure 150/95 mmHg, heart rate 105 bpm, respiratory rate 22 breaths per minute, temperature 100.5°F
Section 1
As the medical team continues to assess the 45-year-old male patient presenting with severe flank pain, further diagnostic investigations are conducted to better understand the underlying cause of his symptoms. A non-contrast CT scan of the abdomen and pelvis is performed, revealing a 7-mm obstructive ureteral stone in the distal ureter, with mild hydronephrosis evident in the right kidney. The stone's position and size suggest that spontaneous passage is unlikely, thus necessitating further intervention to prevent worsening complications such as infection or renal damage.
Laboratory results show an elevation in white blood cell count at 13,000/mm³, indicating a possible concurrent infection. Urinalysis confirms the presence of significant hematuria and pyuria, supporting the suspicion of a urinary tract infection secondary to the obstructing stone. Serum creatinine levels are elevated at 1.6 mg/dL, suggesting a degree of renal impairment, possibly due to the obstructive process. Electrolyte imbalances are noted, with slightly elevated calcium levels at 10.6 mg/dL, which could be contributing to the stone formation process.
Given these findings, the medical team initiates a plan to manage both the obstructive uropathy and the potential infection. The patient is started on an intravenous antibiotic regimen tailored to cover common uropathogens, given his penicillin allergy. Pain management is optimized with intravenous ketorolac, while intravenous fluids are administered to promote diuresis and dilute urinary solutes. A urology consultation is requested for potential surgical intervention, such as ureteroscopy or lithotripsy, to facilitate stone removal. The team closely monitors the patient's vital signs, renal function, and response to treatment, anticipating that timely intervention can prevent further deterioration and ensure a return to baseline health.
Section 2
As the medical team continues to monitor the patient closely, a change in his status is observed that warrants immediate attention. Over the next 24 hours, the patient's pain becomes more diffuse and severe, radiating to the lower abdomen, indicating possible progression of the obstruction. His vital signs reveal a low-grade fever of 100.8°F, a blood pressure of 145/92 mmHg, and a heart rate of 110 beats per minute, suggesting an escalating inflammatory response. Despite the ongoing antibiotic therapy, the patient's symptoms raise concern for a worsening infection and potential sepsis.
Further laboratory tests are conducted to assess the patient’s condition. A repeat complete blood count shows an increased white blood cell count, now at 15,500/mm³, further supporting the diagnosis of a systemic inflammatory response. Blood cultures are drawn to identify any bacteremia, and the results are pending. In addition, a repeat serum creatinine level is noted at 1.8 mg/dL, indicating a continued strain on renal function. Given these findings, the medical team discusses the possibility of needing more aggressive intervention, such as percutaneous nephrostomy, to relieve the obstruction and prevent further renal compromise.
In light of these developments, the team enhances their clinical reasoning by considering potential complications associated with delayed stone removal. They evaluate the risk of pyelonephritis and irreversible renal damage, weighing the benefits and risks of proceeding with immediate surgical intervention versus conservative management. The decision is made to expedite urological intervention, with the team preparing to update the patient and his family about the need for prompt surgical action to address the obstruction and prevent further complications. This step is crucial in curtailing the adverse effects of the obstructive uropathy and preserving renal function, ultimately facilitating the patient's recovery.
Section 3
The medical team proceeds with the urological intervention, performing a percutaneous nephrostomy to alleviate the obstruction. The initial response is positive, with the patient's pain becoming more localized and manageable, suggesting a partial relief of pressure on the renal system. However, over the next few hours, a change in the patient's status is observed. Despite the nephrostomy, the patient exhibits increasing confusion and lethargy, raising concerns about his neurological status. His vital signs show a persistent fever of 101.2°F, heart rate climbing to 120 beats per minute, and a blood pressure now of 150/94 mmHg.
New diagnostic results reveal that the blood cultures drawn earlier have returned positive for Escherichia coli, confirming bacteremia and supporting the suspicion of a systemic infection. Additionally, a repeat urinalysis indicates the presence of nitrites and a significant increase in leukocyte esterase, reinforcing the diagnosis of a urinary tract infection that may have ascended to cause pyelonephritis. The patient’s serum creatinine remains elevated at 1.9 mg/dL, indicating ongoing renal impairment despite the intervention. These findings prompt the medical team to adjust the antibiotic regimen to target the specific pathogen more effectively, while also considering the need for intensive monitoring to prevent the progression to septic shock.
As the patient continues to be closely monitored, the team reflects on the importance of timely intervention and the complexities of managing urological complications. They discuss the potential need for further imaging, such as a CT scan, to assess for any residual stones or additional obstructions, and to guide ongoing management. The team also emphasizes the role of multidisciplinary collaboration in addressing the patient's evolving condition, ensuring that all aspects of care are coordinated to optimize outcomes. This situation underscores the necessity for vigilant observation and adaptability in treatment plans to address new challenges and support the patient's recovery trajectory.
Section 4
The patient's status continues to evolve as the medical team closely monitors his response to the adjusted antibiotic regimen. Within the next 12 hours, there is a notable change in the patient’s condition. His fever has subsided slightly, now at 100.4°F, and his heart rate has decreased to 110 beats per minute, suggesting a partial response to the antibiotics. However, his blood pressure remains elevated at 152/96 mmHg, and he remains lethargic with episodes of confusion. Concerned about the possibility of septic shock, the team initiates a fluid resuscitation protocol to maintain adequate perfusion and oxygen delivery to vital organs.
In light of these changes, the medical team conducts a thorough neurological assessment, noting that the patient's Glasgow Coma Scale score has decreased slightly to 13, indicating mild impairment but not yet critical deterioration. The nephrostomy site is inspected and shows no signs of infection or leakage, ruling out local complications. Given the persistent renal impairment, evidenced by a serum creatinine level now slightly increased to 2.1 mg/dL, the team suspects that the ongoing infection and possible reduced renal perfusion are contributing to the patient's condition and must be addressed promptly.
Recognizing the complexity of the situation, the team decides to order a CT scan to evaluate for any residual kidney stones, additional obstructions, or potential abscess formation that could be exacerbating the infection. The results of the imaging will guide further interventions and help determine if additional surgical or medical strategies are needed to manage the patient's condition effectively. This scenario highlights the critical need for ongoing assessment and the integration of diagnostic findings to form a comprehensive and adaptive care plan.
Section 5
The CT scan results reveal the presence of a 6mm residual kidney stone in the left ureter, causing partial obstruction and contributing to the patient's elevated creatinine levels. Additionally, there is evidence of mild hydronephrosis, suggesting impaired drainage from the kidney. The scan also reveals a small perinephric abscess adjacent to the left kidney, likely exacerbating the infection and causing the ongoing systemic symptoms. These findings necessitate prompt intervention to alleviate the obstruction and address the infection site.
In response to the diagnostic results, the medical team discusses the need for a dual approach: interventional and pharmacological. They decide to perform a ureteroscopy with laser lithotripsy to break down the stone and place a temporary ureteral stent to ensure adequate drainage and relieve the hydronephrosis. Concurrently, the antibiotic regimen is adjusted based on the latest culture sensitivities, ensuring targeted treatment of the abscess. This comprehensive plan aims to reduce the infection load, improve renal function, and stabilize the patient's hemodynamic status.
Monitoring post-intervention, the patient's vital signs show gradual improvement: his heart rate decreases to 98 beats per minute, and blood pressure stabilizes at 138/88 mmHg. The patient becomes more alert, and his Glasgow Coma Scale score improves to 14, indicating a positive neurological response. Serum creatinine levels begin to trend downwards, suggesting improved renal function. While cautiously optimistic, the team continues vigilant monitoring, aware that ongoing assessment and timely adjustments to the care plan remain crucial in navigating potential complications and ensuring the patient's recovery trajectory continues positively.