Wound Care - Nursing Case Study

Pathophysiology

• Primary mechanism: Inflammation - Initiates with vasoconstriction followed by vasodilation, leading to increased permeability and leukocyte infiltration. This stage is critical for removing debris and pathogens but can cause tissue damage if prolonged.

• Secondary mechanism: Proliferation - Characterized by fibroblast activity, collagen deposition, and formation of granulation tissue. Essential for wound closure, but imbalances can lead to hypertrophic scars or impaired healing.

• Key complication: Infection - Disrupts normal healing by prolonging the inflammatory phase and can lead to chronic wounds. Preventing infection is crucial for optimal recovery and involves maintaining a clean environment and monitoring for signs of infection.

Patient Profile

Demographics:

52-year-old female, nurse

History:

• Key past medical history: Type 2 diabetes, hypertension

• Current medications: Metformin, Lisinopril, Aspirin

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Non-healing wound on left lower leg

• Key symptoms: Increased redness and swelling around the wound, moderate pain, occasional fever

• Vital signs: Temperature 100.4°F (38°C), Heart rate 98 bpm, Blood pressure 142/88 mmHg, Respiratory rate 20 breaths per minute

Section 1

New Diagnostic Results:

Following the initial assessment, the healthcare team decided to conduct further diagnostic tests to determine the extent of the wound complications. A wound culture was performed, revealing the presence of Staphylococcus aureus, indicative of a bacterial infection that has likely contributed to the delayed healing. Additionally, a complete blood count (CBC) showed an elevated white blood cell count of 13,500/mm³, further supporting the presence of an active infection. The lab results also indicated a slightly elevated C-reactive protein (CRP) level at 15 mg/L, reflecting systemic inflammation. These findings suggest that the infection is not only localized to the wound but may also be affecting the patient's systemic health, contributing to her occasional fevers and overall feeling of malaise.

Given the patient's history of type 2 diabetes, the risk of complications from wound infections is notably higher due to potential microvascular impairment and reduced immune response. The team must consider the impact of hyperglycemia on wound healing and infection control, as elevated blood glucose levels can impede leukocyte function and enhance bacterial growth. The patient's hemoglobin A1c was found to be 8.2%, indicating suboptimal glycemic control. This warrants the need for tighter glucose management to support effective healing and prevent further complications.

The diagnostic findings have prompted a reassessment of the current treatment plan. The healthcare team is considering the initiation of a broad-spectrum antibiotic, given the patient's penicillin allergy, and will closely monitor her response to this intervention. Additionally, there is a need to explore strategies to improve glycemic control, potentially adjusting her metformin regimen or integrating dietary modifications. These steps are crucial to managing the infection, reducing inflammation, and optimizing the wound healing process. The team will continue to evaluate the patient’s progress through follow-up assessments, focusing on changes in wound appearance, pain levels, and systemic signs of infection.

Section 2

Change in Patient Status:

As the healthcare team implements the revised treatment plan, the patient begins to show signs of both improvement and new challenges. After starting the prescribed broad-spectrum antibiotic, the patient's fever subsides, and her white blood cell count decreases to 11,200/mm³ within a few days, indicating a positive response to the infection management. The wound itself shows initial signs of improvement, with a reduction in erythema and drainage. However, despite these encouraging developments, the patient reports persistent, albeit reduced, fatigue and occasional dizziness.

A closer assessment reveals that her blood glucose levels have been fluctuating unpredictably, with readings ranging from 150 mg/dL to as high as 270 mg/dL. This variability suggests that her glycemic control remains insufficient, potentially due to the stress response from the infection and the body's inflammatory processes. The patient's hemoglobin A1c, while stable at 8.2%, underscores the need for more aggressive diabetes management. The team discusses potential adjustments to her diabetes regimen, considering a possible increase in metformin dosage or the addition of an insulin therapy plan to achieve tighter glucose control.

Despite the initial positive response to antibiotics, the fluctuating blood glucose levels pose a risk for further complications. The care team emphasizes the importance of closely monitoring her blood sugar and making dietary adjustments to stabilize her glucose levels. They also advise on the importance of foot care and regular wound assessments to prevent any new complications. The upcoming follow-up will focus on reassessing her diabetes management plan and evaluating the need for any further interventions to support her recovery and prevent additional setbacks.

Section 3

New Complications:

As the care team continues to monitor the patient's progress, they notice a concerning development. The patient's wound, initially showing signs of improvement, begins to exhibit increased serous drainage and a slight odor, suggesting a potential change in the wound environment. Additionally, the surrounding skin has become more tender and warmer to the touch, raising suspicion of a secondary infection or an evolving abscess. In response, the team orders a wound culture and sensitivity test to identify any new or resistant pathogens that may have colonized the wound despite the ongoing antibiotic therapy.

Concurrent with these changes, the patient's blood pressure readings reveal a new pattern of hypotension, with measurements consistently dropping to 90/60 mmHg. This hypotensive state, coupled with her intermittent dizziness, raises concerns about possible dehydration or an adverse effect of her current medications. The team considers whether the broad-spectrum antibiotic or her recently adjusted medication regimen could be contributing factors. Furthermore, her blood glucose levels remain erratic, oscillating between 140 mg/dL and 300 mg/dL, which complicates the clinical picture and raises the risk of impaired wound healing and additional metabolic stress.

Given these developments, the healthcare team decides to enhance her support with intravenous fluids to address potential dehydration and to revisit her medication schedule to mitigate any adverse effects. They also plan to consult with an endocrinologist to refine her diabetes management strategy, possibly incorporating an insulin regimen tailored to her fluctuating glucose levels. These interventions aim to stabilize her condition, promote wound healing, and prevent further deterioration, setting the stage for the next phase of her recovery journey.

Section 4

New Diagnostic Results:

Following the collection of the wound culture and sensitivity test, the team receives crucial diagnostic results that shed light on the evolving complications. The culture identifies the presence of Methicillin-resistant Staphylococcus aureus (MRSA), a resistant pathogen that necessitates a shift in the antibiotic therapy. The sensitivity profile suggests susceptibility to vancomycin, prompting the team to initiate this targeted antibiotic treatment immediately. Concurrently, blood tests reveal a mild leukocytosis with a white blood cell count of 12,500/mm³, further supporting the suspicion of a secondary infection process. The C-reactive protein level is elevated at 7.5 mg/L, indicating inflammation and aligning with the clinical picture of an ongoing infectious process.

In parallel, an evaluation of the patient's metabolic status highlights a concerning trend in her glycemic control. Hemoglobin A1c results return at 9.2%, underscoring the chronicity and severity of her glucose management issues. This finding, coupled with the erratic daily blood glucose levels, reinforces the need for urgent endocrinological intervention. The endocrinologist recommends the introduction of a basal-bolus insulin regimen to achieve more consistent glucose control, aiming to reduce metabolic stress and enhance wound healing.

Armed with this new information, the healthcare team intensifies their efforts to stabilize the patient. They closely monitor her response to the antibiotic switch and insulin therapy, adjusting the treatment plan as necessary. The team recognizes the interconnectedness of these complications and remains vigilant for further changes in the patient’s condition, understanding that effective management requires a nuanced and dynamic approach. As they continue to address these challenges, the focus remains on supporting the patient's recovery and preventing additional setbacks in her healing journey.

Section 5

As the healthcare team implements the new treatment plan, they closely monitor the patient's response to the interventions. Initially, there is cautious optimism as the patient's vital signs stabilize, with her temperature decreasing to 37.8°C and heart rate normalizing to 88 beats per minute. However, over the next 48 hours, there is an unexpected change in the patient's status that prompts further investigation. Despite the initiation of vancomycin therapy, the wound shows signs of deterioration, with increased erythema, warmth, and a noticeable rise in purulent discharge. These changes raise concerns about the effectiveness of the antibiotic treatment and the potential development of additional complications.

In response to these concerning developments, the team decides to repeat the wound culture to reassess the microbial landscape and ensure that no new resistant organisms have emerged. Additionally, a thorough reassessment of the patient's circulatory and respiratory status is conducted. The patient's oxygen saturation remains stable at 95% on room air, yet she begins to report increased fatigue and mild shortness of breath with exertion. Blood pressure readings fluctuate with a recent drop to 100/60 mmHg, suggesting possible hemodynamic instability. This warrants a more detailed cardiovascular evaluation to rule out any underlying issues that might be contributing to the patient's ongoing symptoms and response to treatment.

The increased fatigue and altered cardiovascular parameters lead the team to consider a broader differential diagnosis, including the possibility of an emerging systemic complication such as sepsis or an adverse drug reaction. As they await the new culture results and further diagnostic tests, the healthcare team remains vigilant, adjusting supportive measures and maintaining close communication with the patient and her family. This proactive approach ensures that any new complications are quickly identified and managed, reinforcing the team's commitment to a holistic and dynamic care strategy tailored to the patient's evolving needs.