bph - Nursing Case Study

Pathophysiology

• Primary mechanism: Hormonal imbalances, particularly increased dihydrotestosterone (DHT) levels, lead to prostate cell proliferation. This results in the enlargement of the prostate gland, which is commonly seen in benign prostatic hyperplasia (BPH).

• Secondary mechanism: The hyperplastic prostate tissue causes compression of the urethra, leading to obstruction of urinary flow. This triggers compensatory changes in bladder function, such as detrusor muscle hypertrophy and increased bladder pressure.

• Key complication: The obstruction and increased bladder pressure can result in urinary retention, frequent urination, and increased risk for urinary tract infections. If severe, it may lead to bladder stones or renal damage due to backflow of urine.

Patient Profile

Demographics:

68-year-old male, retired accountant

History:

• Key past medical history: Benign prostatic hyperplasia (BPH) diagnosed 5 years ago, hypertension, type 2 diabetes

• Current medications: Tamsulosin, Metformin, Lisinopril

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Difficulty urinating and frequent nighttime urination

• Key symptoms: Hesitancy, weak urine stream, urgency, incomplete bladder emptying, nocturia, mild lower abdominal discomfort

• Vital signs: Blood pressure 148/92 mmHg, heart rate 96 bpm, respiratory rate 18 breaths per minute, temperature 99.1°F

Section 1

The patient's condition has progressed over the past few weeks, and he presents to the clinic with new complications. He reports experiencing increased lower abdominal pain and a noticeable decrease in urine output over the past 48 hours. Upon further assessment, the nurse notes a palpable bladder distension, indicating potential acute urinary retention. The patient's vital signs show a slight increase in blood pressure at 152/94 mmHg and a heart rate of 102 bpm, suggesting possible discomfort or stress related to his current urinary issues. Additionally, the patient now complains of bilateral flank pain, raising concerns about potential upper urinary tract involvement.

Laboratory tests are ordered, revealing an elevated serum creatinine level of 1.8 mg/dL, indicating impaired renal function. Urinalysis shows the presence of leukocytes and bacteria, suggesting a urinary tract infection, likely secondary to urinary stasis and retention. An ultrasound of the kidneys and bladder is performed, revealing bilateral hydronephrosis, a concerning sign that urine is backing up into the kidneys due to the obstruction. This finding underscores the need for urgent intervention to prevent further renal damage.

The healthcare team decides to place a urinary catheter to relieve the acute urinary retention and initiate antibiotic therapy to address the infection. The patient is educated on the importance of timely intervention and the potential need for surgical options, such as transurethral resection of the prostate (TURP), if conservative management fails to resolve the obstruction. This escalation in care emphasizes the need for ongoing monitoring of renal function and urinary symptoms, as well as reassessment of his current medication regimen to optimize management of his BPH while considering his comorbid conditions.

Section 2

As the urinary catheter is successfully placed, the patient experiences immediate relief from his acute urinary retention, evidenced by the drainage of a significant volume of urine, which alleviates the palpable bladder distension. However, over the next 24 hours, the healthcare team observes a concerning development: the patient begins to exhibit signs of systemic infection. His temperature rises to 101.3°F (38.5°C), and his heart rate increases further to 112 bpm, suggesting the onset of sepsis. In addition to these symptoms, the patient reports feeling increasingly fatigued and nauseated, with continued bilateral flank pain, raising concerns about pyelonephritis or worsening upper urinary tract infection.

Subsequent laboratory tests reveal a marked increase in white blood cell count to 15,000/mm³, with a left shift indicating an acute inflammatory response. Blood cultures are drawn, and initial results identify the presence of Escherichia coli, confirming the suspicion of bacteremia secondary to his urinary tract infection. The patient's renal function continues to be a critical focus, with serum creatinine now further elevated to 2.1 mg/dL, indicating a progression of renal impairment. Given these findings, the healthcare team promptly escalates the antibiotic regimen to a broader-spectrum intravenous antibiotic in an effort to control the systemic infection and mitigate further renal damage.

Despite these interventions, the patient's condition remains precarious, and a multidisciplinary discussion is initiated to explore more definitive management options, including urgent surgical intervention. The potential need for a transurethral resection of the prostate (TURP) becomes increasingly pressing, as the obstruction continues to pose a significant risk to renal function and overall health. The team also considers the use of nephrostomy tubes as a temporary measure to relieve the pressure on the kidneys. The patient's clinical course underscores the complexity of managing BPH with concurrent infectious and obstructive complications, highlighting the critical importance of timely intervention and continuous reassessment of treatment strategies.

Section 3

As the patient's condition evolves, the healthcare team continues to monitor him closely for any changes in his status. Despite the administration of broad-spectrum intravenous antibiotics, the patient's fever persists, and his heart rate remains elevated at 110 bpm, indicating ongoing systemic inflammation. The patient's blood pressure begins to trend downward, with readings of 95/60 mmHg suggesting a potential hypovolemic or distributive component to his hemodynamic instability. The nursing team notes that the patient is increasingly lethargic and exhibiting signs of confusion, prompting a reassessment of his neurological status.

A repeat set of laboratory tests reveals that the patient's serum lactate level has risen to 3.5 mmol/L, further supporting the diagnosis of sepsis and underscoring the urgency of addressing the underlying infection. Additionally, his renal function continues to decline, with serum creatinine now elevated to 2.4 mg/dL, indicating progressive renal impairment. In light of these developments, the healthcare team intensifies their focus on optimizing fluid resuscitation and vasopressor support to stabilize the patient's hemodynamics while continuing to assess the need for surgical intervention to address the underlying prostatic obstruction.

In parallel, imaging studies, including a renal ultrasound and CT scan of the abdomen, are ordered to evaluate the extent of urinary tract obstruction and potential complications such as hydronephrosis or abscess formation. The imaging results reveal significant bilateral hydronephrosis and a notably enlarged prostate with evidence of bladder outlet obstruction. These findings reinforce the need for a more aggressive approach to relieve the obstruction, and the team schedules an urgent consultation with urology to discuss the feasibility of a transurethral resection of the prostate (TURP) as a definitive measure to resolve the obstruction and prevent further renal compromise. The patient's care plan emphasizes the importance of a collaborative, multidisciplinary approach to address the complex interplay of infectious, obstructive, and renal factors impacting his health.

Section 4

As the healthcare team continues to address the patient's multifaceted condition, they closely monitor his response to the ongoing interventions aimed at stabilizing his hemodynamics and resolving the urinary obstruction. Despite aggressive fluid resuscitation efforts, the patient's blood pressure remains borderline at 92/58 mmHg, and his heart rate has increased to 115 bpm, suggesting persistent circulatory instability. The addition of vasopressor support with norepinephrine is initiated to maintain adequate mean arterial pressure and improve organ perfusion. The patient's urine output has decreased to 20 mL/hour, further indicating worsening renal function. These observations prompt the team to reevaluate their management strategy and prioritize urgent surgical intervention.

In collaboration with the urology team, a decision is made to proceed with an emergency transurethral resection of the prostate (TURP) to relieve the obstruction and potentially reverse the renal impairment. Prior to the procedure, the patient undergoes a pre-operative assessment that reveals a slight deterioration in his respiratory status, as evidenced by an oxygen saturation of 91% on room air and increased work of breathing. Arterial blood gas analysis shows a mild respiratory acidosis with a pH of 7.32 and a PaCO2 of 48 mmHg, suggesting the onset of respiratory compromise secondary to metabolic derangements. The anesthesiology team is alerted to these findings to ensure appropriate intraoperative management and postoperative monitoring.

Post-TURP, the patient is transferred to the intensive care unit for close observation. Initial post-operative assessments indicate a gradual improvement in his hemodynamics, with blood pressure readings now trending upward to 105/65 mmHg and heart rate slightly decreasing to 108 bpm. Serum lactate levels have begun to normalize, now at 2.8 mmol/L, indicating a positive response to the surgical intervention and ongoing supportive measures. However, the patient remains at risk for further complications, necessitating vigilant monitoring for potential post-operative bleeding, infection, or electrolyte imbalances. The multidisciplinary team remains engaged, emphasizing the importance of continued collaboration to guide the patient's recovery and address any emerging challenges in his clinical course.

Section 5

As the patient settles into the intensive care unit post-TURP, the healthcare team conducts thorough initial assessments to identify any immediate post-operative complications. Notably, the patient exhibits mild hematuria, a common occurrence after TURP, but the team remains vigilant for signs of significant bleeding. His oxygen saturation has improved to 94% on 2 liters of supplemental oxygen via nasal cannula, and his work of breathing has decreased, suggesting better respiratory function following the surgical relief of obstruction. However, there is a new development of low-grade fever at 38.4°C (101.1°F), raising concerns about potential infection, given the invasive nature of the procedure and the patient's recent hemodynamic instability.

Laboratory results reveal a white blood cell count of 12,500/mm³, indicating a possible inflammatory response or early infection. The urinalysis shows cloudy urine with elevated leukocytes and a positive nitrite test, pointing towards a urinary tract infection likely exacerbated by the urinary stasis and catheterization. Considering these findings, the team initiates empiric antibiotic therapy and sends urine cultures to guide targeted treatment. Electrolyte monitoring indicates a mild hyponatremia with a serum sodium level of 132 mmol/L, likely secondary to the fluid shifts and ongoing intravenous fluid therapy. The care team adjusts the patient's fluid management to address this imbalance while closely monitoring for any additional metabolic derangements.

In response to these developments, the team emphasizes the importance of frequent monitoring and reassessment to catch any further complications early. The patient's recovery trajectory will depend on swiftly addressing the infection, correcting electrolyte imbalances, and ensuring adequate organ perfusion. The evolving clinical picture requires continuous interdisciplinary collaboration, with the nursing staff playing a crucial role in ongoing assessments and communication with the medical team. The plan includes maintaining hemodynamic support, optimizing respiratory care, and ensuring meticulous wound and catheter care to promote healing and prevent further infectious complications. The patient’s progress will be continuously evaluated, with adjustments made to his care plan as needed to support his recovery and prevent further deterioration.