iron deficiency anaemia - Nursing Case Study
Pathophysiology
• Primary mechanism: Iron deficiency anemia primarily occurs due to inadequate iron availability, which is essential for hemoglobin synthesis. This leads to reduced hemoglobin levels and, consequently, impaired oxygen transport capacity of red blood cells.
• Secondary mechanism: The body's iron storage in the liver, spleen, and bone marrow diminishes over time due to chronic blood loss, poor dietary intake, or malabsorption, further exacerbating anemia by limiting erythropoiesis (production of red blood cells).
• Key complication: As a result of decreased oxygen delivery to tissues, patients may experience symptoms such as fatigue, pallor, and dyspnea. In the long term, this can lead to compensatory mechanisms like tachycardia and eventual cardiac strain if untreated.
Patient Profile
Demographics:
34-year-old female, office manager
History:
• Past medical history: History of heavy menstrual bleeding, previous diagnosis of mild iron deficiency anemia
• Current medications: Ferrous sulfate 325 mg daily, oral contraceptive pill
• Allergies: No known drug allergies
Current Presentation:
• Chief complaint: Increased fatigue and dizziness over the past month
• Key symptoms: Shortness of breath on exertion, pale skin, brittle nails, occasional heart palpitations
• Vital signs: Blood pressure 100/60 mmHg, heart rate 98 bpm, respiratory rate 20 breaths per minute, temperature 98.6°F
Section 1
As the case progresses, the patient returns for a follow-up appointment after her initial presentation with increased fatigue and dizziness. Despite adherence to her current treatment regimen of ferrous sulfate and oral contraceptives, her symptoms have not improved, prompting the healthcare provider to order a comprehensive set of laboratory tests to evaluate her iron status and overall hematologic health. The results reveal a hemoglobin level of 9.5 g/dL, hematocrit of 30%, and mean corpuscular volume (MCV) of 70 fL, all indicative of microcytic anemia. Her serum ferritin is markedly low at 10 ng/mL, confirming depleted iron stores, while her total iron-binding capacity (TIBC) is elevated at 450 mcg/dL, suggesting an increased capacity for iron binding due to deficiency.
Further investigation into her gastrointestinal system is warranted to rule out additional causes of iron loss or malabsorption, given the persistence of her anemia despite supplementation. An occult blood test is negative, and there are no signs of gastrointestinal bleeding, which shifts the focus to potential absorption issues or increased menstrual losses. The healthcare provider considers the possibility of inadequate absorption of oral iron, possibly due to poor gastrointestinal absorption or issues related to the formulation of the supplement. A trial of intravenous iron therapy is proposed to bypass gastrointestinal absorption and directly replenish iron stores, with close monitoring of her response and potential side effects.
Clinically, the patient is exhibiting mild compensatory tachycardia with a heart rate of 110 bpm at rest, a sign that her cardiovascular system is under strain due to the chronic anemia. This reinforces the need for a more aggressive approach to treatment to prevent further cardiac complications. The healthcare team discusses with the patient the importance of follow-up and monitoring, including regular laboratory tests to track her hemoglobin and iron levels, as well as adjustments to her treatment plan. This will ensure timely intervention and prevent the progression of her condition, while also exploring lifestyle modifications to support her recovery.
Section 2
Following the initiation of intravenous iron therapy, the patient returns for a follow-up appointment two weeks later. Clinically, she reports a slight improvement in energy levels and a reduction in dizziness, though she still experiences significant fatigue. Her heart rate has decreased to 95 bpm at rest, indicating a mild improvement in her cardiovascular strain. New laboratory results are promising; her hemoglobin has increased to 10.5 g/dL, and her hematocrit has risen to 32%. However, her mean corpuscular volume (MCV) remains low at 72 fL, suggesting that while her iron levels are improving, the microcytic anemia has not yet fully resolved. Serum ferritin levels have increased to 30 ng/mL, providing evidence that her iron stores are beginning to replenish.
Despite these improvements, the healthcare team remains concerned about the underlying cause of her iron deficiency. Given the negative occult blood test and the absence of gastrointestinal bleeding, further evaluation of potential malabsorption issues is warranted. A referral to a gastroenterologist is made for further assessment, including the possibility of celiac disease or other malabsorption syndromes that could be interfering with oral iron absorption. Additionally, a pelvic ultrasound is scheduled to assess for potential uterine abnormalities, such as fibroids, which could contribute to increased menstrual losses.
The healthcare provider discusses with the patient the importance of continuing her current treatment plan and attending all scheduled specialist appointments. They emphasize the need for ongoing monitoring of her iron levels and symptoms to ensure that any new complications are promptly identified and managed. The patient is advised to maintain a diet rich in iron, vitamin C, and other essential nutrients to support her recovery. As she leaves the clinic, the plan is set for another follow-up in four weeks to reassess her progress and make any necessary adjustments to her treatment regimen based on the outcomes of the specialist evaluations.
Section 3
At her follow-up appointment four weeks later, the patient presents with new symptoms of intermittent abdominal discomfort and frequent diarrhea. Despite a continued slight improvement in energy levels, she reports experiencing more pronounced fatigue and occasional palpitations. Her vital signs reveal a resting heart rate of 105 bpm and a blood pressure of 110/70 mmHg. Physical examination shows mild pallor and conjunctival paleness, indicative of persistent anemia. Her laboratory results indicate a hemoglobin level of 10.2 g/dL and a hematocrit of 31%, reflecting a slight regression compared to her previous labs. The mean corpuscular volume (MCV) remains low at 70 fL, and her serum ferritin is stable at 28 ng/mL, suggesting that while iron stores are not depleting rapidly, her body is struggling to maintain adequate hemoglobin synthesis.
The gastroenterologist's evaluation reveals positive serology for celiac disease, indicating that malabsorption is a likely contributor to her iron deficiency anemia. The pelvic ultrasound results return normal, ruling out uterine abnormalities as a source of significant blood loss. With these findings, the healthcare team hypothesizes that the patient's iron deficiency anemia is primarily due to malabsorption secondary to celiac disease, complicating her recovery despite intravenous iron therapy.
In response to these developments, the care team initiates a gluten-free diet to address the underlying malabsorption issue. They emphasize the importance of dietary adherence and close monitoring of her symptoms and lab values. Additionally, they plan to continue intravenous iron supplementation, adjusting the dosage as needed to support her iron levels while her gastrointestinal health improves. The patient is scheduled for another follow-up in four weeks, at which time her response to the dietary changes and the stability of her anemia will be reassessed. This plan aims to stabilize her condition and address both the symptomatic anemia and its root cause, guiding her towards a more sustainable recovery.
Section 4
At the next follow-up appointment four weeks later, the patient reports a noticeable improvement in her gastrointestinal symptoms since starting the gluten-free diet. She mentions that her diarrhea has significantly reduced, and she experiences less frequent abdominal discomfort. However, she still feels fatigued, although the severity of her palpitations has decreased. Her energy levels have shown a modest improvement, allowing her to resume some of her daily activities with less difficulty.
Upon examination, her vital signs indicate a slight improvement: her resting heart rate has decreased to 95 bpm, and her blood pressure is stable at 112/72 mmHg. Physical examination still reveals mild pallor, but her conjunctival paleness appears slightly less pronounced. Laboratory results show a modest improvement in her hemoglobin level, now at 10.8 g/dL, and her hematocrit is 33%. Her mean corpuscular volume (MCV) remains low at 71 fL, but her serum ferritin has increased to 32 ng/mL, suggesting a positive response to the continued intravenous iron therapy and dietary changes.
Despite these improvements, the care team remains vigilant, as her anemia persists, albeit with slight progress. They decide to continue with the current regimen of intravenous iron supplementation and strict adherence to the gluten-free diet. The team discusses the potential for long-term dietary management and the need for ongoing monitoring of her iron levels and overall health. They plan to reassess her condition in another four weeks, aiming to further stabilize her anemia and evaluate any additional intervention needs. This follow-up will be crucial for determining the success of the treatment plan and addressing any lingering issues that might arise as her body adjusts to the dietary changes.
Section 5
Four weeks later, the patient returns for her scheduled follow-up appointment. She reports that her energy levels have plateaued despite adhering strictly to her gluten-free diet and completing her course of intravenous iron therapy. While she no longer experiences palpitations, her fatigue persists, and she has developed mild shortness of breath on exertion. She also mentions a new sensation of tingling in her fingertips and toes, raising concerns about potential neurological involvement.
Upon examination, her vital signs are stable with a resting heart rate of 90 bpm and blood pressure of 110/70 mmHg. However, her physical assessment reveals some concerning changes: her pallor has not improved, and her conjunctiva remains pale. Neurological examination highlights diminished sensation in her extremities, suggesting possible peripheral neuropathy. A review of her laboratory results indicates that her hemoglobin level has slightly increased to 11.2 g/dL, but her mean corpuscular volume (MCV) remains low at 70 fL. Notably, her serum vitamin B12 level is now borderline low at 230 pg/mL, raising suspicion of concurrent vitamin B12 deficiency contributing to her anemia and new neurological symptoms.
Given these findings, the care team decides to expand their diagnostic evaluation to include additional tests to assess vitamin B12 absorption and potential malabsorption issues beyond gluten sensitivity. They plan to initiate vitamin B12 supplementation while continuing to monitor her iron levels and dietary adherence. The team acknowledges the complexity of her case, emphasizing the need for a multifaceted approach to address both her hematologic and neurological symptoms. This new development prompts them to consider the broader implications of her nutritional deficiencies, setting the stage for a comprehensive reassessment of her treatment plan in the coming weeks.