endometriosis - Nursing Case Study

Pathophysiology

• Primary mechanism: Retrograde menstruation involves menstrual blood containing endometrial cells flowing backward through the fallopian tubes into the pelvic cavity, where they implant and grow outside the uterus, leading to endometriosis lesions.

• Secondary mechanism: Immune system dysfunction allows ectopic endometrial cells to persist and proliferate, as the body fails to recognize and eliminate these misplaced cells, contributing to chronic inflammation and lesion development.

• Key complication: Chronic pelvic pain and infertility arise from the inflammatory response and scar tissue formation, which can distort pelvic anatomy and interfere with normal reproductive function.

Patient Profile

Demographics:

28-year-old female, nurse

History:

• Key past medical history: Diagnosed with endometriosis 3 years ago, history of ovarian cysts

• Current medications: Oral contraceptives, Ibuprofen as needed

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Increasing pelvic pain and irregular menstrual cycles

• Key symptoms: Severe dysmenorrhea, chronic fatigue, bloating, occasional nausea

• Vital signs: Blood pressure 138/90 mmHg, heart rate 92 bpm, temperature 98.9°F, respiratory rate 18 breaths per minute

Section 1

New Diagnostic Results:

As the patient's symptoms persisted and worsened, further diagnostic evaluations were initiated to better understand her condition. A pelvic ultrasound was performed, which revealed a significant increase in the size of previously identified ovarian cysts, now measuring over 5 cm, indicative of endometriomas, commonly known as "chocolate cysts." Additionally, a magnetic resonance imaging (MRI) scan was ordered to assess the extent of endometriosis implants and potential involvement of other pelvic structures. The MRI findings showed extensive endometrial implants on the uterosacral ligaments and rectovaginal septum, with notable adhesions suggesting advanced-stage endometriosis. These results confirmed that the disease had progressed beyond initial expectations, contributing to her increased pain and irregular menstrual cycles.

Laboratory tests were also conducted to evaluate the patient’s inflammatory status and hormonal levels. Results showed elevated CA-125 levels, a marker often associated with endometriosis severity, and a slight elevation in C-reactive protein (CRP), indicating ongoing inflammation. Her hormone profile was consistent with anovulatory cycles, likely contributing to the irregular menstrual patterns and presenting an additional challenge to her reproductive health. These findings necessitated a multidisciplinary approach, involving both gynecologists and pain management specialists, to address the complex interplay of her symptoms and formulate a comprehensive treatment plan aimed at reducing pain, managing cysts, and improving her quality of life.

These new diagnostic insights prompted a discussion of potential next steps, including the consideration of surgical intervention, such as laparoscopy, to excise endometriosis lesions and potentially preserve fertility. The patient’s desire for future fertility options needed careful consideration in treatment planning, balancing aggressive management of symptoms with her reproductive goals. This situation called for careful clinical reasoning and patient-centered decision-making, as the healthcare team strategized interventions that align with her personal and health priorities.

Section 2

New Complications:

As the healthcare team continued to monitor the patient's condition, new complications emerged that required immediate attention. The patient began experiencing increased severity and frequency of pelvic pain, accompanied by new gastrointestinal symptoms, including constipation and rectal bleeding. These developments raised concerns about potential bowel involvement, a known complication of advanced endometriosis. A subsequent colonoscopy revealed partial bowel obstruction due to endometriotic lesions infiltrating the sigmoid colon, exacerbating her symptoms and necessitating urgent intervention.

In light of these findings, the patient's pain management regimen was re-evaluated. While she was previously managed with non-steroidal anti-inflammatory drugs (NSAIDs) and hormonal therapy, her escalating pain and gastrointestinal complications prompted the consideration of stronger analgesics and possibly surgical intervention to relieve bowel obstruction. Her vital signs remained stable, with a blood pressure of 115/75 mmHg and a heart rate of 82 bpm, but her hemoglobin levels had decreased to 10.2 g/dL, suggesting mild anemia likely related to chronic inflammation and menstrual blood loss.

Given these developments, the multidisciplinary team, including a colorectal surgeon, discussed the possibility of a laparoscopic surgery not only to excise the obstructive endometriotic lesions but also to evaluate and potentially treat other pelvic adhesions. This new complication underscored the urgency of comprehensive treatment, balancing immediate surgical needs with the patient's long-term fertility goals. The team aimed to alleviate the acute symptoms while minimizing impacts on her reproductive health, requiring a finely-tuned clinical reasoning approach to address both the complexity of her condition and her personal health priorities.

Section 3

Following the decision to proceed with surgical intervention, the patient underwent a successful laparoscopic procedure to excise the endometriotic lesions causing the bowel obstruction. Intraoperative findings confirmed significant endometriotic involvement of the sigmoid colon, along with multiple adhesions throughout the pelvic cavity. The surgical team carefully excised the lesions and adhesions, striving to preserve as much healthy tissue as possible to protect the patient's fertility. Postoperatively, the patient was transferred to the recovery unit, where she was closely monitored for any immediate complications.

In the days following her surgery, the patient demonstrated a notable improvement in her pelvic pain and gastrointestinal symptoms. Her bowel function began to normalize, with a gradual return to regular bowel movements and resolution of rectal bleeding. However, she reported fatigue and continued to exhibit mild anemia, with her hemoglobin level slightly improving to 10.5 g/dL. The healthcare team initiated iron supplementation to address her anemia and scheduled follow-up appointments to monitor her recovery and evaluate the need for ongoing hormonal therapy.

Despite the positive surgical outcome, the team remained vigilant for potential new complications, particularly the risk of recurrence of endometriotic lesions. The patient's discharge plan included detailed education on recognizing signs of recurrence or complications, emphasizing the importance of adherence to follow-up care and any prescribed medical therapies. As she prepared for discharge, discussions about her long-term reproductive goals resumed, with plans to engage a reproductive endocrinologist to explore fertility-preserving options. This collaborative approach highlighted the need for ongoing clinical reasoning to balance immediate symptom relief with her future quality of life and reproductive aspirations.

Section 4

Two weeks after the patient's discharge, she returned for her scheduled follow-up appointment. During the initial assessment, she reported a significant reduction in pelvic pain and improved bowel function, indicating a positive response to the surgical intervention. However, she expressed concerns about persistent fatigue and occasional episodes of lightheadedness. Her vital signs were stable, with a blood pressure of 110/70 mmHg and a heart rate of 82 beats per minute. On physical examination, her surgical incisions were healing well, with no signs of infection or dehiscence. However, laboratory tests revealed that her hemoglobin level remained at 10.5 g/dL, indicating persistent mild anemia despite adherence to the iron supplementation regimen.

In light of these findings, the healthcare team explored potential causes of her anemia and fatigue. Further diagnostic tests, including a peripheral blood smear and serum ferritin levels, were ordered to evaluate iron stores and rule out other causes of anemia such as chronic disease or low vitamin B12 levels. The peripheral blood smear was unremarkable, but serum ferritin was found to be at the lower end of normal, suggesting that iron deficiency remained a contributor. The team decided to increase the dosage of her oral iron supplementation and recommended dietary adjustments to enhance iron absorption. Additionally, the team considered whether hormonal therapy might be impacting her hematological status, prompting a review of her current medications and their potential side effects.

The healthcare team emphasized the importance of monitoring her symptoms and maintaining follow-up appointments to reassess her response to the modified treatment plan. They also continued discussions on fertility preservation, with a referral to a reproductive endocrinologist to further explore options such as cryopreservation of oocytes. As the patient navigated these challenges, the collaborative efforts of her multidisciplinary care team were crucial in addressing both her immediate health needs and long-term reproductive goals, ensuring a holistic approach to her recovery and quality of life.

Section 5

A month later, the patient returned for a follow-up visit, during which she reported mixed improvements in her symptoms. While her pelvic discomfort remained well-managed, she noted that her fatigue had worsened. She also began experiencing unusual bruising on her arms and legs without any significant trauma. Her vital signs were stable, with a blood pressure of 108/68 mmHg and a heart rate of 80 beats per minute. However, a repeat complete blood count revealed a further decline in her hemoglobin level to 9.8 g/dL. Additionally, her platelet count was slightly decreased at 135,000/µL, which, although still within the lower limit of normal, suggested a potential new issue.

Given these findings, the healthcare team became concerned about the possibility of a secondary condition contributing to her hematological abnormalities. They ordered a comprehensive metabolic panel and assessed her liver function, given the potential impact of her hormonal therapy on hepatic processes. The liver enzymes were mildly elevated, prompting further investigation into the possibility of drug-induced liver injury or an underlying hepatic condition. The team also considered her nutritional status, exploring whether gastrointestinal absorption issues might be exacerbating her anemia and fatigue.

In response to these developments, the care team adjusted her treatment plan, temporarily discontinuing her hormonal therapy to observe any changes in her symptoms and lab values. They increased the frequency of her follow-up appointments to closely monitor her clinical status and emphasized the importance of maintaining adequate nutrition and hydration. The patient was also referred to a hematologist for further evaluation of her anemia and thrombocytopenia. This proactive approach aimed to address the emerging complications while continuing to support her overall recovery and long-term health goals.