depression and anxiety - Nursing Case Study
Pathophysiology
• Primary mechanism: Neurotransmitter imbalance – Depression and anxiety are often linked to dysregulation of serotonin, norepinephrine, and dopamine, which are crucial for mood regulation and stress response. This imbalance can lead to altered mood and heightened anxiety.
• Secondary mechanism: Hypothalamic-pituitary-adrenal (HPA) axis dysfunction – Chronic stress can lead to overactivation of the HPA axis, resulting in excessive cortisol production. This can impair the brain's ability to manage stress and can exacerbate symptoms of both depression and anxiety.
• Key complication: Neuroplasticity alterations – Prolonged exposure to stress and neurotransmitter imbalance can reduce neuroplasticity, particularly in the hippocampus, which is involved in mood regulation and cognitive function. This can lead to persistent mood disorders and an increased risk of chronic anxiety and depression.
Patient Profile
Demographics:
32-year-old female, graphic designer
History:
• Key past medical history: History of generalized anxiety disorder for 5 years, moderate depression diagnosed 3 years ago, occasional migraines
• Current medications: Sertraline 100 mg daily, Alprazolam 0.5 mg as needed, Ibuprofen 200 mg as needed for migraines
• Allergies: Penicillin
Current Presentation:
• Chief complaint: Increased anxiety and depressive symptoms over the past month
• Key symptoms: Persistent sadness, fatigue, difficulty concentrating, insomnia, increased irritability, occasional panic attacks
• Vital signs: Blood pressure 145/92 mmHg, heart rate 98 bpm, respiratory rate 22 breaths per minute, temperature 98.6°F
Section 1
New Complications:
Over the past two weeks, the patient has developed a notable decrease in appetite, leading to a weight loss of approximately five pounds. She reports feeling overwhelmed by daily tasks, which contributes to her increased sense of hopelessness. Despite adhering to her medication regimen, she has experienced more frequent and intense panic attacks, occurring at least three times a week. Her sleep disturbances have worsened, with frequent awakenings and difficulty returning to sleep, leaving her feeling more fatigued during the day. The patient's blood pressure remains elevated at 148/94 mmHg, and her heart rate has increased slightly to 102 bpm, suggesting a physiological response to heightened anxiety and stress.
In response to these symptoms, a new set of laboratory tests was ordered to further explore potential underlying causes and rule out other conditions. The results revealed elevated cortisol levels, confirming a hyperactive HPA axis, which may be exacerbating her psychiatric symptoms. Additionally, her thyroid function tests indicated mild hypothyroidism, a condition that can contribute to depressive symptoms and fatigue. These findings suggest a complex interplay of physical and psychological factors contributing to her current state, requiring a reevaluation of her treatment plan.
Given the new complications, the healthcare team must consider adjusting the patient's medication regimen, possibly incorporating a beta-blocker to manage her elevated heart rate and blood pressure, and exploring options to address her thyroid dysfunction. The team should also consider a referral to a therapist specializing in cognitive-behavioral therapy to help manage her anxiety and depression more effectively. These steps aim to stabilize her condition, enhance her quality of life, and prevent further deterioration in her mental health.
Section 2
Following the evaluation of the patient's recent symptoms and the new diagnostic findings, the healthcare team initiated several interventions aimed at addressing both her physiological and psychological challenges. The patient was started on a low-dose beta-blocker, specifically propranolol, to manage her elevated heart rate and blood pressure. Within a week, her vital signs showed slight improvement, with her heart rate reducing to 88 bpm and her blood pressure stabilizing at 132/86 mmHg. This adjustment brought a modest sense of relief, as she reported a decrease in the intensity of her palpitations during panic attacks.
Concurrently, the endocrinologist recommended commencing levothyroxine therapy to address her mild hypothyroidism. After two weeks on this regimen, the patient reported a subtle increase in energy levels and a slight improvement in her ability to concentrate. These changes, however, were tempered by the persistence of her anxiety and depressive symptoms. In response to these ongoing challenges, the healthcare team facilitated a referral to a cognitive-behavioral therapist, and the patient began attending weekly sessions. Early feedback from therapy sessions indicated a slight reduction in feelings of hopelessness, as she started to develop coping strategies to manage her overwhelming emotions.
Despite these positive steps, the patient continues to struggle with sleep disturbances, which remain a significant barrier to her recovery. Her sleep hygiene has been reviewed, and non-pharmacological strategies, such as establishing a bedtime routine and minimizing screen time before bed, have been advised. However, her sleep issues persist, suggesting the need for further evaluation and possible introduction of a sleep aid. As the team continues to monitor her progress, the focus remains on achieving a holistic balance in her treatment plan, taking into account her physiological responses, psychological resilience, and overall well-being.
Section 3
As the healthcare team continued to monitor the patient's progress, they observed a change in her status that warranted further investigation. Over the course of several days, the patient began to experience increased fatigue and a return of palpitations, despite the initial improvements seen with propranolol and levothyroxine. During a follow-up visit, her vital signs revealed a heart rate that had increased to 95 bpm and blood pressure readings fluctuating between 138/90 mmHg and 140/92 mmHg. Concerned about these developments, the team ordered a comprehensive blood panel and a repeat thyroid function test to assess potential underlying causes for these changes.
The new diagnostic results showed that the patient's TSH levels had decreased to 0.2 mIU/L, indicating that she might be experiencing symptoms of subclinical hyperthyroidism, possibly due to over-supplementation with levothyroxine. Additionally, her hemoglobin levels were slightly below normal at 11.5 g/dL, suggesting mild anemia, which could be contributing to her fatigue. These findings prompted a re-evaluation of her medication regimen, particularly the dosage of levothyroxine, to prevent exacerbation of her cardiovascular symptoms and manage her energy levels more effectively.
In light of these developments, the healthcare team decided to adjust the patient's levothyroxine dose and incorporate dietary recommendations to address the anemia. Iron-rich foods and possibly an iron supplement were advised to improve her hemoglobin levels. Meanwhile, the cognitive-behavioral therapy sessions continued to assist the patient in developing resilience against her anxiety and depressive symptoms. By integrating these adjustments into her treatment plan, the team sought to stabilize her physical health while supporting her psychological recovery, thereby creating a more comprehensive approach to her ongoing care. These interventions set the stage for further monitoring and potential modifications as her condition evolves.
Section 4
As the healthcare team continued to monitor the patient’s response to the adjusted treatment plan, they noted some promising improvements in her condition. With the reduction in her levothyroxine dose, the patient’s heart rate stabilized to a more manageable 82 bpm, and her blood pressure readings showed a modest improvement, consistently ranging between 130/85 mmHg and 132/86 mmHg. These changes suggested that the adjustments were effective in mitigating her cardiovascular symptoms. The patient also reported feeling slightly less fatigued and more energetic during daily activities, which could be attributed to both the medication adjustment and the introduction of iron supplements into her diet. A follow-up complete blood count revealed a modest increase in her hemoglobin level to 12.0 g/dL, indicating a positive response to the dietary and supplemental interventions for anemia.
However, despite these improvements, the patient continued to experience intermittent episodes of anxiety, particularly during stressful situations. These episodes were characterized by mild palpitations and increased perspiration, which seemed to coincide with external stressors rather than an underlying physiological cause. The cognitive-behavioral therapy sessions remained a cornerstone of her treatment, helping her develop strategies to manage her anxiety more effectively. The healthcare team also explored potential triggers that might be exacerbating her anxiety, such as caffeine intake and sleep hygiene, and provided appropriate counseling to help her modify these lifestyle factors.
Given the complexity of her condition, the team remained vigilant and emphasized the importance of regular follow-up visits to closely monitor her progress. They recognized that while the current interventions were showing signs of success, the patient's journey toward recovery required ongoing evaluation and flexibility in her treatment plan. This approach ensured that any emerging complications or changes in her status could be promptly addressed, maintaining a holistic focus on both her physical and mental health. Through continuous assessment and collaborative care, the team aimed to support the patient in achieving sustained improvements and enhancing her quality of life.
Section 5
Several weeks into her adjusted treatment plan, the patient presented for a follow-up appointment, where new diagnostic results painted a more comprehensive picture of her evolving health status. The healthcare team noted that while her cardiovascular symptoms remained stable with a heart rate consistently around 80 bpm and blood pressure readings averaging 128/84 mmHg, there were emerging concerns revealed through her lab results. A recent thyroid function test indicated that her TSH levels had slightly decreased to 0.3 mIU/L, suggesting a need to reassess her thyroid medication dosage to prevent further hyperthyroid symptoms, which could exacerbate her anxiety issues.
Additionally, a new challenge emerged as her fasting blood glucose level was recorded at 112 mg/dL, hinting at the onset of impaired glucose tolerance. This result prompted the team to consider the implications of this finding in relation to her overall health and the potential impact on her mental health conditions. The patient reported experiencing increased thirst and occasional blurred vision, which, when corroborated with the glucose findings, suggested that her metabolic health needed closer monitoring and intervention.
In response to these developments, the healthcare team prioritized a comprehensive approach that integrated both her physical and mental health needs. They engaged in clinical reasoning to adjust her treatment plan, considering the interaction between her thyroid function, glucose regulation, and anxiety management. The team decided to consult an endocrinologist to fine-tune her levothyroxine dosage and recommended the initiation of lifestyle modifications to address her glucose levels, such as dietary changes and a gradual increase in physical activity. This collaborative effort aimed to preemptively manage potential complications while continuing to support her mental well-being through ongoing therapy and stress management techniques. By maintaining a vigilant and adaptive care strategy, the team sought to enhance the patient's resilience and facilitate her progress toward a balanced and healthier state.