Epilepsy - Nursing Case Study

Pathophysiology

• Primary mechanism: Epilepsy primarily results from abnormal, excessive electrical discharges in the brain's neurons, leading to recurrent, unprovoked seizures. This hyperexcitability is often due to imbalances between excitatory neurotransmitters like glutamate and inhibitory neurotransmitters like GABA, disrupting normal brain activity.

• Secondary mechanism: Structural or functional alterations within the brain, such as scar tissue from injury, infection, or developmental anomalies, can create focal points for these discharges. These alterations may facilitate the synchronization of neuronal firing, contributing to seizure propagation.

• Key complication: Chronic seizures can lead to neuronal damage and cognitive impairment over time, affecting quality of life and increasing the risk of comorbidities such as anxiety and depression, necessitating comprehensive management strategies.

Patient Profile

Demographics:

35-year-old female, school teacher

History:

• Key past medical history: Diagnosed with epilepsy at age 25, history of generalized tonic-clonic seizures, occasional migraines

• Current medications: Levetiracetam 1000 mg twice daily, Lamotrigine 150 mg twice daily

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Increased frequency of seizures over the past month

• Key symptoms: Aura with dizziness and visual disturbances, postictal confusion lasting longer than usual, occasional shortness of breath

• Vital signs: Blood pressure 145/90 mmHg, heart rate 98 bpm, respiratory rate 22 breaths per minute, temperature 98.6°F, oxygen saturation 92% on room air

Section 1

Change in Patient Status:

During her stay in the hospital for observation and further evaluation, the patient experienced a notable change in her condition. Despite adhering to her medication regimen, she had another generalized tonic-clonic seizure that lasted approximately three minutes. Postictally, her confusion persisted for an extended period of over an hour, raising concerns about prolonged recovery. Additionally, her oxygen saturation dropped to 88% during the seizure, which required supplemental oxygen to stabilize her levels back to 94%. Her blood pressure spiked to 160/95 mmHg during the episode, and she reported a severe headache post-seizure, which was atypical for her usual postictal state.

The medical team decided to perform a series of diagnostic tests to uncover potential underlying issues contributing to the increased frequency and severity of the seizures. An electroencephalogram (EEG) revealed increased epileptiform activity compared to previous studies, suggesting heightened neuronal excitability. A brain MRI was ordered to rule out any structural changes or lesions that might be acting as a new focal point for seizure activity. Blood tests indicated a slight decrease in serum sodium levels, raising the possibility of hyponatremia as a contributing factor, although it was not severe enough to be the sole cause of the clinical changes.

These findings prompted the healthcare team to consider adjusting her medication regimen. They deliberated on the possibility of introducing an additional antiepileptic drug or increasing the dosage of her current medications while monitoring for potential side effects. The patient's recent stressors, including increased workload and lack of sleep due to her teaching responsibilities, were discussed as potential exacerbating factors. The team also emphasized the importance of lifestyle modifications and coping strategies to manage stress and improve her overall condition.

Section 2

The medical team decided to introduce an additional antiepileptic drug, levetiracetam, to the patient's regimen to address the increased epileptiform activity and prevent further seizure episodes. Over the next 48 hours, the patient's condition was closely monitored for any changes in seizure frequency, potential side effects, and overall response to the medication adjustment. During this period, the patient reported feeling slightly more fatigued, which was anticipated as a possible side effect of the new medication, but she did not experience any further seizures. Her vital signs remained stable, although her blood pressure was intermittently elevated, with readings fluctuating between 150/90 mmHg and 155/92 mmHg. The nursing staff continued to provide supplemental oxygen as needed, ensuring her saturation levels remained above 92%.

In conjunction with the medication adjustment, the patient participated in a consultation with a hospital-based occupational therapist who provided strategies to manage her workload and integrate relaxation techniques into her daily routine. The patient expressed concerns about her ability to adhere to these recommendations due to her demanding teaching schedule, but she acknowledged the importance of stress management in controlling her epilepsy. Blood tests were repeated to monitor her serum sodium levels, which showed a slight improvement, now at 134 mEq/L, indicating mild hyponatremia was being addressed, though not entirely resolved.

The team planned to reassess the patient's condition after a week to evaluate the effectiveness of the new medication and lifestyle modifications. They scheduled a follow-up EEG to compare against the recent findings and determine any changes in neuronal activity. The medical team also discussed the possibility of referring the patient to a neurologist specializing in epilepsy for a more comprehensive evaluation and potential long-term management plan, considering the recent complications and her complex lifestyle factors.

Section 3

Two days after the introduction of levetiracetam, the patient began experiencing intermittent headaches and increased irritability, which were initially attributed to the medication’s side effects. However, the nursing team noted that her blood pressure remained consistently elevated, with readings now ranging from 160/95 mmHg to 165/98 mmHg, raising concerns about potential hypertensive complications. Despite these changes, the patient’s seizure frequency remained unchanged, with no episodes reported since the medication adjustment. To further investigate her condition, the medical team ordered a comprehensive metabolic panel, which revealed a further decrease in serum sodium levels to 130 mEq/L, indicating worsening hyponatremia. This electrolyte imbalance was suspected to be contributing to her neurological symptoms and hypertension.

In response to these findings, the medical team initiated a fluid restriction protocol and adjusted her diuretic therapy to carefully manage her sodium levels. Additionally, the team decided to schedule a renal function test to rule out any underlying kidney issues that could be exacerbating her hyponatremia and hypertension. The patient’s workload and stress levels were re-evaluated with the occupational therapist, who emphasized the importance of adherence to recommended relaxation techniques. The patient expressed a willingness to try these strategies more consistently, recognizing the potential impact of stress on her blood pressure and overall health.

To address the potential complications, a multidisciplinary meeting was held to discuss the patient’s progress and plan further interventions. The possibility of introducing an antihypertensive medication was considered, but the team decided to first focus on correcting the sodium imbalance. The patient was encouraged to maintain a strict adherence to her medication regimen and lifestyle adjustments, with a follow-up appointment scheduled to reassess her condition in three days. This approach aimed to stabilize her vital signs and improve her neurological status, setting the stage for a more comprehensive evaluation by the specialized neurologist in epilepsy management.

Section 4

Three days after implementing the fluid restriction protocol and diuretic adjustment, the patient returned for her follow-up assessment. During the initial evaluation, the nursing team observed that her blood pressure had decreased slightly but remained elevated, with readings ranging from 150/90 mmHg to 155/92 mmHg. The patient reported a slight reduction in headache severity but continued to experience irritability and fatigue, which concerned the healthcare team. A repeat comprehensive metabolic panel was ordered to assess her electrolyte status. The results showed a marginal improvement in serum sodium levels, now at 132 mEq/L, but still below the normal range, indicating persistent hyponatremia.

In addition to the laboratory findings, the renal function test results were reviewed, which revealed a mild decline in kidney function with a glomerular filtration rate (GFR) of 58 mL/min/1.73m², suggesting early-stage chronic kidney disease. This finding prompted the medical team to consider the impact of compromised renal function on her blood pressure and electrolyte imbalance. In response, the healthcare team decided to collaborate with a nephrologist to refine her treatment plan, aiming to prevent further renal deterioration while managing her hypertension and sodium levels.

Recognizing the interconnected nature of her symptoms and lab findings, the medical team emphasized the importance of a holistic approach to her care. The patient was advised to continue her stress-reduction techniques and maintain adherence to dietary modifications tailored to support kidney health and improve electrolyte balance. The collaborative effort aimed to stabilize her condition and prevent the emergence of further complications, setting the stage for a comprehensive evaluation by the specialized neurologist and nephrologist in the coming weeks.

Section 5

During the follow-up visit, the nursing team conducted a thorough assessment of the patient, noting several changes in her condition. The patient's blood pressure readings remained somewhat elevated, but there was a noticeable decrease to 148/88 mmHg. Despite this slight improvement, she reported experiencing new episodes of dizziness and a persistent feeling of lethargy. Additionally, the patient mentioned that her headaches had become more localized and intense, particularly in the mornings. Physical examination revealed mild pedal edema and slightly dry mucous membranes, indicating potential fluid imbalance.

The latest laboratory results, which included a complete blood count and additional metabolic panel, showed further insights into her condition. Her serum sodium level continued to be low at 130 mEq/L, and there was a concerning drop in her serum potassium level to 3.4 mEq/L, suggesting hypokalemia. Her hemoglobin level was slightly reduced at 11.5 g/dL, which raised the possibility of an emerging anemia that could contribute to her fatigue and dizziness. The GFR had declined slightly to 55 mL/min/1.73m², prompting further concern about her renal health.

These findings prompted the healthcare team to adjust her treatment plan. A decision was made to carefully titrate her diuretic therapy to address the hypokalemia while ensuring adequate blood pressure control. The team considered the addition of potassium supplements and explored alternative antihypertensive medications that would be less taxing on her renal function. The patient was educated on recognizing symptoms of electrolyte imbalance and the importance of adhering to her dietary and fluid intake recommendations. The team also planned for an expedited consultation with the nephrologist and neurologist to refine her management and address the interconnected complications of her epilepsy, hypertension, and kidney function. This comprehensive approach aimed to prevent further deterioration and stabilize her condition.