Hypertension - Nursing Case Study

Pathophysiology

• Primary mechanism: Increased systemic vascular resistance (SVR) - Hypertension often results from constricted or narrowed blood vessels, which increase resistance to blood flow. This requires the heart to work harder to pump blood, elevating blood pressure chronically.

• Secondary mechanism: Renin-angiotensin-aldosterone system (RAAS) dysregulation - Overactivity of the RAAS leads to excessive production of angiotensin II, a potent vasoconstrictor, and increased aldosterone secretion, which causes sodium and water retention, further elevating blood pressure.

• Key complication: Damage to target organs - Chronic high blood pressure can lead to complications like heart failure, kidney damage, and increased risk of stroke due to the sustained pressure on blood vessels and organs, emphasizing the importance of managing hypertension effectively.

Patient Profile

Demographics:

55-year-old male, office manager

History:

• Key past medical history: Diagnosed with hypertension 5 years ago, family history of cardiovascular disease

• Current medications: Lisinopril 20 mg daily, Hydrochlorothiazide 25 mg daily

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Persistent headaches and fatigue

• Key symptoms: Dizziness, occasional shortness of breath, and chest tightness

• Vital signs: Blood pressure 160/100 mmHg, heart rate 92 bpm, respiratory rate 18 breaths per minute, temperature 98.6°F

Section 1

New Complications:

During a routine follow-up appointment, the patient reports worsening symptoms, including increased frequency of dizziness and more pronounced chest tightness that occasionally radiates to his left arm. His blood pressure remains elevated at 165/105 mmHg despite adherence to his medication regimen. Concerned about these developments, the healthcare provider orders additional diagnostic tests, including an electrocardiogram (ECG) and serum electrolyte panel. The ECG reveals left ventricular hypertrophy, a sign of the heart adapting to the chronic pressure overload, while the electrolyte panel indicates mild hypokalemia (serum potassium level of 3.2 mEq/L), likely a side effect of the long-term use of hydrochlorothiazide.

These findings suggest that the patient is developing moderate complications from his uncontrolled hypertension. The left ventricular hypertrophy indicates that the heart muscle is thickening, which may lead to a decreased ability to pump blood effectively, potentially progressing to heart failure if not addressed. The hypokalemia is concerning as it can exacerbate cardiac symptoms and increase the risk of arrhythmias, especially in the context of existing cardiovascular strain. This scenario necessitates a critical review of his current treatment plan, integrating clinical reasoning to consider adjustments such as modifying his medication regimen to include a potassium-sparing diuretic or an angiotensin receptor blocker (ARB) to better manage his blood pressure and protect cardiac function.

As the patient continues to experience these symptoms and diagnostic results indicate complications, the healthcare team must explore potential interventions that address both the immediate risks and long-term health outcomes. This includes close monitoring of his cardiovascular status, electrolyte levels, and renal function, as well as patient education on lifestyle modifications that can contribute to better blood pressure control. The unfolding situation underscores the importance of a comprehensive approach to managing hypertension, emphasizing the need for regular re-evaluation and adaptation of treatment strategies to prevent further target organ damage.

Section 2

Change in Patient Status:

Following the adjustments in his medication regimen, which now includes a potassium-sparing diuretic and an angiotensin receptor blocker (ARB), the patient initially reports a slight improvement in his blood pressure readings, with home measurements averaging around 150/95 mmHg. However, within a few weeks, he begins to experience new symptoms, including persistent fatigue, swelling in his lower extremities, and shortness of breath during mild exertion. He returns for another follow-up appointment, where the healthcare provider conducts a thorough assessment.

During this visit, the patient’s vital signs reveal a blood pressure of 155/100 mmHg, heart rate of 88 beats per minute, and respiratory rate of 20 breaths per minute. Physical examination highlights bilateral pitting edema in the ankles and mild jugular venous distention, suggesting fluid overload. Concerned about these findings, the provider orders additional tests, including a repeat ECG, serum electrolyte panel, and a chest X-ray. The ECG now shows signs of strain, with T-wave inversions in the lateral leads, indicating possible ischemic changes. The serum electrolyte panel reveals normalization of potassium levels at 4.0 mEq/L, but the patient’s serum creatinine has risen to 1.6 mg/dL, suggesting a decline in renal function. The chest X-ray indicates mild pulmonary congestion.

These developments indicate that the patient is experiencing early signs of congestive heart failure, likely related to the long-standing effects of uncontrolled hypertension and left ventricular hypertrophy. The healthcare team must now consider further intervention strategies, such as optimizing diuretic therapy to manage fluid retention and prevent further cardiac decompensation. Enhanced monitoring of renal function and patient education on recognizing warning signs of heart failure are also crucial as the patient navigates this new phase of his health journey. This scenario presents an opportunity for the team to refine the treatment plan, reinforcing the need for a dynamic and integrative approach to managing complex hypertensive cases.

Section 3

Change in Patient Status:

In response to the new clinical findings, the healthcare team decides to adjust the patient’s treatment plan by increasing the dosage of the potassium-sparing diuretic to better manage the fluid overload. Additionally, a low-dose beta-blocker is introduced to address the signs of cardiac strain and improve heart function. The patient is advised to closely monitor his blood pressure, weight, and any changes in symptoms at home, with specific instructions to report any sudden weight gain or worsening shortness of breath.

Two weeks into the revised treatment regimen, the patient returns for a follow-up appointment. His blood pressure is now reading 145/92 mmHg, indicating a modest improvement. However, he reports intermittent dizziness and a persistent dry cough, which raises concern about the side effects of his medications. On physical examination, there is a slight reduction in the severity of pitting edema, but jugular venous distention remains present, and auscultation of the lungs reveals faint crackles at the bases. The patient's heart rate is 82 beats per minute, with a respiratory rate of 18 breaths per minute. Laboratory tests show stable potassium levels at 4.2 mEq/L, but the serum creatinine has further increased to 1.8 mg/dL, suggesting a continued decline in renal function.

These findings indicate a partial response to the treatment adjustments, but the development of a dry cough and rising creatinine levels necessitate further investigation. The healthcare team considers the possibility of ARB-induced renal impairment and contemplates transitioning to an alternative antihypertensive regimen. Additionally, the beta-blocker could be contributing to the patient's dizziness, warranting a re-evaluation of its dosage or the need for a substitute. This scenario underscores the complexity of managing comorbid conditions in hypertensive patients and highlights the importance of ongoing evaluation and flexibility in treatment planning.

Section 4

Upon review of the patient's current symptoms and laboratory findings, the healthcare team decides to prioritize the investigation of the increased serum creatinine levels and dry cough, both of which are concerning for possible medication-related complications. Given the patient's partial response to the current regimen and the potential adverse effects associated with the ARB and beta-blocker, the team orders additional diagnostic tests, including a renal ultrasound to evaluate kidney structure and function, and pulmonary function tests to explore the etiology of the cough.

The renal ultrasound reveals no significant structural abnormalities, ruling out obstructive causes of renal impairment. However, the glomerular filtration rate (GFR) is calculated at 52 mL/min/1.73m², indicating stage 3a chronic kidney disease. This finding, along with the elevated creatinine, suggests that the ARB may be contributing to reduced renal perfusion. Meanwhile, pulmonary function tests show mild restrictive patterns, consistent with the reported cough and possibly related to the beta-blocker therapy.

Given these insights, the healthcare team decides to discontinue the ARB and introduce a calcium channel blocker, aiming to reduce the renal burden while maintaining effective blood pressure control. Additionally, the beta-blocker dosage is reduced to mitigate dizziness and respiratory side effects. The patient is counseled on the medication changes and the importance of adhering to follow-up appointments for continuous monitoring of renal function, blood pressure, and symptom resolution. This strategic adjustment in the treatment plan underscores the importance of individualized patient care and the need for vigilant monitoring to prevent further complications.

Section 5

Two weeks following the adjustment in her medication regimen, the patient returns for a follow-up appointment. She reports a noticeable improvement in her symptoms, particularly a reduction in the frequency and severity of her cough. However, she mentions experiencing some mild peripheral edema, which she attributes to the new calcium channel blocker. Her blood pressure readings at home have been relatively stable, averaging around 135/85 mmHg, which is an improvement from her previous levels. In the clinic, her vital signs include a blood pressure of 138/88 mmHg, heart rate of 72 beats per minute, respiratory rate of 16 breaths per minute, and oxygen saturation of 98% on room air.

Laboratory tests reveal a slight improvement in kidney function, with serum creatinine levels decreasing to 1.5 mg/dL from the previous 1.7 mg/dL. The glomerular filtration rate (GFR) has improved marginally to 55 mL/min/1.73m², suggesting a positive response to the discontinuation of the ARB. Electrolytes remain within normal limits, and there is no evidence of significant electrolyte imbalance, which is reassuring given the recent medication changes.

Despite these improvements, the patient reports new-onset mild headaches and occasional palpitations, raising concerns about the adequacy of her current blood pressure management. The healthcare team decides to closely monitor these symptoms, recognizing the importance of balancing effective blood pressure control with the minimization of adverse effects. A plan is made to reassess her medication regimen at the next follow-up, considering further dose adjustments or alternative therapeutic options if necessary. This careful monitoring underscores the dynamic nature of managing hypertension, particularly when associated with chronic kidney disease, and highlights the need for ongoing clinical evaluation and patient education.