GERD - Nursing Case Study
Pathophysiology
• Primary mechanism: Lower esophageal sphincter (LES) dysfunction - The LES, a critical barrier between the stomach and esophagus, becomes weakened or relaxes inappropriately, allowing acidic gastric contents to reflux into the esophagus, leading to irritation and inflammation.
• Secondary mechanism: Impaired esophageal clearance - Ineffective peristalsis or reduced saliva production delays the clearance of refluxed acid from the esophagus, exacerbating mucosal damage and symptoms such as heartburn and regurgitation.
• Key complication: Esophagitis - Persistent acid exposure damages the esophageal lining, causing inflammation (esophagitis), which can lead to complications like esophageal strictures or Barrett's esophagus, increasing the risk of esophageal cancer if untreated.
Patient Profile
Demographics:
45 years old, female, office manager
History:
• Key past medical history: Diagnosed with GERD 5 years ago, history of obesity, hypertension
• Current medications: Omeprazole 20 mg daily, Lisinopril 10 mg daily
• Allergies: Penicillin
Current Presentation:
• Chief complaint: Persistent heartburn and difficulty swallowing
• Key symptoms: Regurgitation, chronic cough, hoarseness, worsening chest pain after meals
• Vital signs: Blood pressure 145/92 mmHg, heart rate 88 bpm, respiratory rate 20 breaths per minute, temperature 98.7°F
Section 1
New Complications:
During a follow-up appointment, the patient reports that her symptoms have progressively worsened over the past few weeks. She now experiences severe chest pain that radiates to her back, especially after eating, and has noticed an increase in her chronic cough and hoarseness. She also mentions that she sometimes wakes up at night gasping for air. Concerned about these symptoms, the primary care provider orders an upper endoscopy, which reveals significant esophageal inflammation and several shallow ulcers. Additionally, a barium swallow study shows a narrowing of the esophagus suggestive of an esophageal stricture.
The clinical team is particularly concerned about the development of Barrett's esophagus, a condition where the normal tissue lining the esophagus changes to tissue that resembles the lining of the intestine. This is confirmed by biopsy results showing intestinal metaplasia. With this new diagnosis, the patient is at an increased risk for esophageal adenocarcinoma, necessitating regular surveillance endoscopies. The gastroenterologist recommends a more aggressive treatment approach, including a possible increase in the dose of proton pump inhibitors and consideration of surgical options to address the lower esophageal sphincter dysfunction and prevent further progression of Barrett's esophagus.
These developments prompt the clinical team to reevaluate the patient's management plan comprehensively. There is a need for improved symptom control and prevention of further complications. The patient's weight and blood pressure are also revisited as part of a holistic approach to managing her GERD and associated conditions. A referral to a dietitian is made to assist with weight management, which could help reduce intra-abdominal pressure and improve GERD symptoms. Additionally, lifestyle modifications such as dietary changes, sleeping position adjustments, and smoking cessation (if applicable) are discussed to optimize her overall treatment strategy.
Section 2
Change in Patient Status:
Following the implementation of the revised management plan, the patient returns for a follow-up visit after two months. She reports partial improvement in her symptoms, noting that the severity of her chest pain has decreased, and she experiences less frequent episodes of coughing and hoarseness. However, she continues to have nocturnal symptoms, occasionally waking up with a sensation of choking. She admits to struggling with dietary changes, citing difficulty in adhering to a low-fat, low-acid diet, and reports only a minimal weight loss of two pounds since her last visit.
The clinical team conducts a comprehensive assessment, noting her vital signs: blood pressure at 142/88 mmHg, heart rate of 78 beats per minute, respiratory rate of 18 breaths per minute, and oxygen saturation at 96% on room air. Her weight is recorded at 220 pounds, reflecting a BMI of 32. The physical exam reveals mild tenderness in the epigastric region but no palpable masses. Despite the partial relief from increased proton pump inhibitor dosage, the persistent nocturnal symptoms raise concerns about the effectiveness of the current therapeutic regimen and adherence to lifestyle modifications.
Given these findings, the clinical team deliberates on the next steps, considering the potential need for surgical intervention to address the lower esophageal sphincter dysfunction. They discuss the possibility of a laparoscopic fundoplication to provide long-term relief and prevent further progression of Barrett’s esophagus. Concurrently, the patient is encouraged to engage more actively with the dietitian to optimize her dietary habits and explore additional strategies for weight management. The team also considers the introduction of a nighttime alginate-based formulation to provide a physical barrier against reflux during sleep, aiming to enhance symptom control and improve the patient’s quality of life.
Section 3
Response to Interventions:
Over the next month, the patient adheres to the newly introduced nighttime alginate-based formulation, which provides some improvement in her nocturnal symptoms. She reports fewer episodes of waking up with a choking sensation, although occasional occurrences persist. Encouraged by this progress, she makes a concerted effort to engage with the dietitian, resulting in more consistent adherence to dietary recommendations. However, her weight remains relatively stable, with only an additional one-pound loss, indicating challenges in achieving significant weight reduction.
In a follow-up appointment, the clinical team notes a slight improvement in the patient's overall symptomatology, but persistent issues with nocturnal reflux indicate that the underlying problem may not be fully addressed. Her vital signs show minimal changes: blood pressure at 140/86 mmHg, heart rate of 76 beats per minute, respiratory rate of 18 breaths per minute, and oxygen saturation at 97% on room air. Physical examination reveals ongoing mild tenderness in the epigastric region, with no new findings. Given the partial response to non-surgical interventions and the potential risk of progression to Barrett’s esophagus, the team re-evaluates the possibility of surgical intervention, specifically the laparoscopic fundoplication, as a viable option for definitive management.
The patient expresses apprehension about surgery but is willing to consider it if it offers a more comprehensive solution to her ongoing issues. The team emphasizes the importance of achieving better control of her reflux symptoms to prevent long-term complications. They schedule a consultation with a surgical specialist to discuss the potential benefits and risks of the procedure, as well as to explore preoperative considerations. This decision marks a pivotal point in her care plan, potentially altering her trajectory towards improved quality of life and reduced risk of complications associated with chronic GERD.
Section 4
New Complications:
As the patient awaits her consultation with the surgical specialist, she begins to experience new symptoms that prompt another visit to her primary care provider. Over the past week, she has noticed increased frequency of heartburn and regurgitation during the daytime, despite adherence to her alginate-based treatment and dietary modifications. She also reports a persistent cough and occasional hoarseness, which she initially attributed to seasonal allergies. However, these symptoms have become more pronounced and frequent, raising concern for potential respiratory complications associated with her GERD.
Upon examination, her vital signs remain stable, with a blood pressure of 138/84 mmHg, heart rate of 80 beats per minute, and respiratory rate of 20 breaths per minute. Oxygen saturation remains at 97% on room air. However, auscultation of the lungs reveals scattered wheezes bilaterally, a new finding since her last visit. This suggests possible micro-aspiration of gastric contents, leading to reactive airway symptoms. Additionally, the patient describes a sour taste in her mouth more frequently, indicating increased acid exposure that may not be fully managed with current interventions.
These developments complicate the clinical picture and underscore the need for timely intervention to prevent further progression of her GERD and related complications. The team decides to expedite her surgical consultation, given the potential for worsening respiratory issues and the risk of developing Barrett’s esophagus. They also consider implementing a PPI therapy adjustment in the interim to provide better control of acid secretion and alleviate her symptoms. This new phase of her care requires careful coordination and prompt action to address the evolving challenges in her management.
Section 5
The patient's primary care provider decides to order additional diagnostic tests to gather more information about the potential respiratory complications related to her GERD. A chest X-ray is performed, which reveals mild bilateral infiltrates suggestive of aspiration-related changes. To further assess the extent of esophageal acid exposure and its impact on the lungs, a 24-hour esophageal pH monitoring and impedance study is scheduled. This will help determine the frequency and correlation of acid reflux episodes with her respiratory symptoms. Blood tests are also conducted, showing a mild elevation in the white blood cell count, which could indicate an inflammatory response, possibly due to micro-aspiration.
Given the new findings, the healthcare team discusses adjusting her current management plan. They decide to switch her to a higher-dose proton pump inhibitor (PPI) therapy, with the aim of reducing gastric acid production more effectively. This modification is intended to decrease the acidity of any refluxate, thereby minimizing further damage to the esophagus and reducing respiratory complications. The patient is also advised to elevate the head of her bed and avoid eating for at least three hours before lying down, as these measures can help prevent nocturnal reflux and improve her cough and hoarseness.
These steps are taken while awaiting the results of the diagnostic studies and the upcoming surgical consultation. The healthcare team remains vigilant for any signs of worsening respiratory distress or further complications, such as the development of Barrett’s esophagus, which remains a concern given her ongoing symptoms. The focus is on optimizing her current therapeutic regimen to stabilize her condition and prevent further progression, ensuring that she receives comprehensive care during this critical phase of her treatment journey.