Infection - Nursing Case Study

Pathophysiology

• Primary mechanism: Pathogen invasion and multiplication - Pathogens such as bacteria, viruses, or fungi enter the body, exploiting breaches in the skin or mucosal barriers, and multiply, leading to tissue damage and the release of toxins.

• Secondary mechanism: Immune response activation - The body's immune system detects the invading pathogens, triggering an inflammatory response that includes the release of cytokines, increased blood flow, and recruitment of white blood cells to contain and eliminate the infection.

• Key complication: Systemic Inflammatory Response Syndrome (SIRS) - In some cases, the immune response becomes dysregulated, leading to widespread inflammation, which can result in systemic complications such as sepsis, characterized by organ dysfunction and potentially life-threatening outcomes.

Patient Profile

Demographics:

45-year-old female, school teacher

History:

• Key past medical history: Type 2 Diabetes, Hypertension

• Current medications: Metformin, Lisinopril

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Fever and persistent cough

• Key symptoms: Shortness of breath, fatigue, chest pain, productive cough with green sputum

• Vital signs: Temperature 101.8°F, Heart Rate 110 bpm, Respiratory Rate 24 breaths per minute, Blood Pressure 138/88 mmHg, Oxygen Saturation 93% on room air

Section 1

As the medical team conducted an initial assessment of the 45-year-old female patient, several findings were noted that indicated her condition was becoming more concerning. Upon auscultation, decreased breath sounds were detected in the lower lobes of both lungs, accompanied by crackles, suggesting potential consolidation due to pneumonia. Her productive cough was producing thick, green sputum, indicative of a bacterial infection. Laboratory tests were initiated, including a complete blood count (CBC), blood cultures, and sputum cultures, to identify the causative organism and determine appropriate antibiotic therapy, considering her penicillin allergy.

Blood tests revealed an elevated white blood cell count of 17,000 cells/mm³, pointing to a heightened immune response. C-reactive protein (CRP) was significantly raised at 80 mg/L, further indicating systemic inflammation. Blood cultures returned positive for Streptococcus pneumoniae, confirming bacterial pneumonia. Given her Type 2 Diabetes, this infection posed a greater risk of complications. The team started her on a course of levofloxacin, an antibiotic suitable for her allergy profile, and provided supplemental oxygen to maintain her oxygen saturation above 95%.

Within 24 hours, the patient's condition showed signs of stability, with a slight reduction in fever and improved respiratory rate. However, her blood pressure remained borderline, hinting at potential compromise in perfusion, necessitating close monitoring for signs of sepsis. The team continued to assess her response to treatment, looking for improvements in her respiratory status and overall systemic condition, while being vigilant for any new complications such as acute kidney injury or further cardiovascular strain due to her underlying hypertension. This ongoing evaluation would guide further therapeutic decisions and interventions, ensuring her recovery trajectory remained favorable.

Section 2

Despite initial signs of stabilization, the patient's condition began to change after 48 hours of treatment. Her oxygen saturation, which had been maintained above 95% with supplemental oxygen, began to fluctuate, occasionally dropping to 92% on room air. This prompted a reassessment of her respiratory status. Upon auscultation, the crackles in her lower lung fields persisted, and new wheezing was noted, suggesting possible bronchospasm or worsening pulmonary involvement. The medical team was concerned about the progression of the pneumonia or potential secondary complications such as pleural effusion or acute respiratory distress syndrome (ARDS).

New diagnostic imaging, including a chest X-ray, was ordered to evaluate the current status of her lung consolidation. The results showed increased opacification in the right lower lobe and the appearance of a small pleural effusion, indicating a potential complication. In light of these findings, her management plan was adjusted. The team increased the frequency of her respiratory therapy, including nebulized bronchodilators, to address the wheezing, and continued to monitor her oxygen requirements closely.

Additionally, her renal function tests showed a mild increase in creatinine levels from 0.9 mg/dL to 1.3 mg/dL, raising concern for acute kidney injury potentially due to dehydration, medication side effects, or the systemic effects of the infection. Her fluid balance was reassessed, and intravenous fluids were adjusted to ensure adequate hydration while avoiding fluid overload. The nursing team was tasked with strict monitoring of her intake and output, as well as ongoing assessments of her renal function and overall hemodynamic status. These interventions aimed to stabilize her condition and prevent further deterioration, while the medical team prepared for the possibility of escalating her care if necessary.

Section 3

As the medical team adjusted the treatment plan, the nursing staff noted a change in the patient's status during the next shift. Her respiratory rate increased to 28 breaths per minute, and her heart rate rose to 110 beats per minute, suggesting a possible compensatory response to hypoxia or worsening infection. Despite the nebulized bronchodilators, her wheezing persisted, and the patient reported increased fatigue and difficulty breathing. Her oxygen saturation continued to fluctuate, occasionally dropping to 90% even with supplemental oxygen. These changes prompted an immediate reassessment by the healthcare team, focusing on both her respiratory and overall clinical status.

Further diagnostic tests were conducted to explore the possibility of new complications. An arterial blood gas (ABG) test revealed a pH of 7.30, PaCO2 of 50 mmHg, and PaO2 of 58 mmHg on supplemental oxygen, indicating respiratory acidosis with hypoxemia. These findings were concerning for either an exacerbation of her pneumonia or the development of acute respiratory distress syndrome (ARDS). In parallel, her lab results showed a further increase in creatinine to 1.5 mg/dL and a BUN of 25 mg/dL, reinforcing concerns about acute kidney injury. Given these developments, the medical team decided to escalate her care, contemplating the need for non-invasive ventilation or potential transfer to the intensive care unit for more aggressive respiratory support.

The nursing team continued meticulous monitoring of her vital signs, oxygenation status, and fluid balance. They collaborated closely with the medical team to ensure timely interventions, such as adjusting her fluid therapy and reassessing her medication regimen to mitigate any nephrotoxic effects. This coordinated approach aimed to stabilize her respiratory function and renal status while preparing for further escalation of care if her condition continued to deteriorate.

Section 4

As the medical team continued to monitor the patient closely, the next phase of diagnostic testing provided critical insights into her evolving condition. A repeat chest X-ray was ordered to assess the progression of her respiratory issues. The results indicated bilateral infiltrates, raising the suspicion of acute respiratory distress syndrome (ARDS) rather than a simple exacerbation of pneumonia. This finding, combined with her worsening respiratory acidosis and hypoxemia, confirmed the need for more aggressive respiratory support. Consequently, the decision was made to initiate Bi-level Positive Airway Pressure (BiPAP) therapy to improve her ventilation and oxygenation while avoiding the need for immediate intubation.

Concurrent with the respiratory concerns, lab work revealed worrying trends in her renal function. Although her creatinine and BUN levels were elevated, urinalysis showed no signs of hematuria or proteinuria, suggesting that her kidney issues might be a result of acute tubular necrosis due to hypoperfusion rather than an intrinsic renal pathology. The team adjusted her fluid management strategy, aiming to optimize her hemodynamic status and support her renal recovery while being mindful of her fluid balance to prevent exacerbating her respiratory condition.

The nursing staff played a critical role in implementing these adjustments by meticulously tracking her input and output, monitoring her response to BiPAP therapy, and providing thorough skin assessments to prevent pressure injuries. They also communicated any subtle changes in her mental status or vital signs to the medical team promptly. Despite the challenges, the initial response to these interventions was cautiously optimistic. Her respiratory rate gradually decreased to 24 breaths per minute, and her oxygen saturation improved to 94% on BiPAP. However, her condition remained tenuous, and the healthcare team was vigilant in anticipating any further complications that could arise, particularly the potential for multi-organ dysfunction if her respiratory and renal issues did not stabilize. This careful balance of intervention and monitoring was critical as they prepared for the next steps in her care.

Section 5

As the team continued to closely monitor the patient, new complications began to emerge, challenging the initial cautious optimism. Despite the initial improvement in her respiratory status with BiPAP therapy, she began to exhibit signs of altered mental status, including confusion and restlessness. This change prompted a thorough neurological assessment and a reevaluation of her overall clinical picture. Vital signs revealed a slight increase in heart rate to 110 beats per minute and a drop in blood pressure to 88/58 mmHg, indicating potential hemodynamic instability.

Further lab results showed a concerning trend: her lactate levels had risen to 3.5 mmol/L, suggesting evolving tissue hypoperfusion and a possible shift towards septic physiology. Her white blood cell count remained elevated at 16,000/mm³, and a blood culture drawn earlier returned positive for gram-negative rods, confirming bacteremia. These findings pointed towards the development of sepsis, likely secondary to her respiratory infection. As a result, the medical team promptly initiated a broad-spectrum antibiotic regimen, ensuring coverage for gram-negative organisms, and intensified her fluid resuscitation with cautious administration of crystalloids to support her blood pressure and mitigate the risk of further renal compromise.

In response to these changes, the nursing staff increased the frequency of monitoring, paying particular attention to neurological status, urine output, and signs of potential deterioration in respiratory function. They also emphasized the importance of frequent repositioning and skin care to prevent pressure injuries, given her increased risk due to hemodynamic instability and altered consciousness. This vigilant approach was crucial as the team navigated the complexities of managing a patient with emerging multi-organ dysfunction, balancing the need for aggressive intervention with the risk of exacerbating existing complications. The focus was now on stabilizing her condition and preventing further decline, while preparing for the possibility of more invasive interventions if her status did not improve.