cancer - Nursing Case Study

Pathophysiology

• Primary mechanism: Genetic Mutations - Cancer begins with genetic mutations in the DNA of a single cell, leading to uncontrolled cell growth. These mutations can activate oncogenes or deactivate tumor suppressor genes, disrupting normal cell cycle regulation and apoptosis.

• Secondary mechanism: Angiogenesis - Tumor cells release growth factors that stimulate the formation of new blood vessels, supplying the tumor with oxygen and nutrients necessary for its growth and ability to metastasize to distant sites.

• Key complication: Metastasis - Cancer cells invade surrounding tissues and enter the bloodstream or lymphatic system, spreading to other parts of the body. This complicates treatment and significantly worsens the prognosis by establishing secondary tumors.

Patient Profile

Demographics:

62-year-old female, retired school teacher

History:

• Key past medical history: Hypertension, Type 2 Diabetes, Breast cancer diagnosed 2 years ago

• Current medications: Metformin, Lisinopril, Tamoxifen

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Increasing fatigue and shortness of breath over the past month

• Key symptoms: Persistent cough, unintended weight loss, night sweats

• Vital signs: Blood pressure 145/90 mmHg, heart rate 110 bpm, respiratory rate 24 breaths per minute, temperature 100.4°F, oxygen saturation 90% on room air

Section 1

Following her initial presentation, the nursing team conducts a comprehensive assessment of the patient to gather more detailed information about her current condition. On auscultation, diminished breath sounds are noted in the lower lobes of the lungs with occasional wheezing, suggestive of possible pleural effusion or lung involvement due to metastasis. Her heart sounds are slightly tachycardic but regular, and peripheral edema is noted, indicating potential fluid overload or compromised cardiac function. A detailed physical examination reveals palpable lymphadenopathy in the axillary and supraclavicular regions, raising concerns for possible metastatic spread.

A complete blood count and metabolic panel are ordered, revealing anemia with a hemoglobin level of 9.5 g/dL, which could be contributing to her increased fatigue. Her blood glucose is slightly elevated at 165 mg/dL, likely due to stress and her underlying diabetes. A chest X-ray is performed and shows multiple small nodular densities in both lungs, along with a moderate right-sided pleural effusion, confirming suspicions of metastatic spread from her previously diagnosed breast cancer. This finding necessitates further diagnostic imaging, such as a CT scan, to better delineate the extent of metastasis and guide treatment planning.

To address her shortness of breath and declining oxygen saturation, the nursing team initiates supplemental oxygen therapy at 2 liters per minute via nasal cannula, which improves her saturation to 94%. The oncology team is consulted to consider adjustments in her chemotherapy regimen to address the new metastatic lesions. The patient's care plan is updated to include monitoring for signs of respiratory distress and adjustments in her diabetes management to account for her increased metabolic demands. The healthcare team prepares for a multidisciplinary meeting to discuss potential interventions, including thoracentesis for symptomatic relief of the pleural effusion and possible changes to her systemic therapy to manage the metastatic disease effectively.

Section 2

The multidisciplinary team convenes to discuss the patient's current status and the next steps in her management plan. During this meeting, they review the results of the recent CT scan, which reveals multiple metastatic lesions in the liver, in addition to the pulmonary involvement. This finding explains her persistent fatigue, elevated liver enzymes, and mild jaundice noted during the physical examination. The team acknowledges that these liver metastases are contributing to her anemia, as well as her slightly elevated blood glucose levels due to impaired liver function. With these new diagnostic results, the oncology team proposes an adjustment in her chemotherapy regimen to include agents specifically targeted at the metastatic spread to both the lungs and liver.

As the team strategizes a comprehensive approach, they prioritize alleviating the patient's immediate symptoms. A thoracentesis is performed to relieve the right-sided pleural effusion, resulting in immediate improvement in her respiratory status. Post-procedure, her oxygen saturation stabilizes at 96% on room air, and her dyspnea significantly decreases. The nursing team continues to monitor her closely for any signs of recurrence of the effusion or respiratory distress, ensuring prompt intervention if necessary. Meanwhile, adjustments in her diabetes management are implemented to maintain tighter glucose control, considering her altered metabolic state.

Despite these interventions, new complications arise. The patient develops mild confusion and disorientation, prompting the team to investigate potential causes such as hepatic encephalopathy due to liver involvement or hypercalcemia, which is a common paraneoplastic syndrome associated with breast cancer. Serum calcium levels are measured and found to be elevated at 12.3 mg/dL, confirming hypercalcemia. The team initiates intravenous hydration with normal saline and considers bisphosphonate therapy to address this metabolic complication. This development highlights the need for ongoing reassessment and adaptation of her care plan to manage both existing conditions and emerging challenges, ensuring a holistic and patient-centered approach to her complex clinical presentation.

Section 3

As the patient continues her journey through this complex clinical scenario, the healthcare team observes a change in her status that demands immediate attention. Despite initial improvements following thoracentesis and adjustments in her diabetes management, the patient's confusion and disorientation persist, raising concerns about her neurological status. Her vital signs remain relatively stable, with a blood pressure of 118/76 mmHg, pulse of 88 beats per minute, and respiratory rate of 20 breaths per minute. However, her mental status fluctuates, and she occasionally struggles to stay oriented to time and place.

Recognizing the urgency of addressing her neurological symptoms, the team orders further diagnostic tests, including an MRI of the brain, to rule out central nervous system involvement. The MRI reveals small metastatic lesions in the brain, suggesting a more widespread dissemination of her cancer. In response to this new finding, the oncology team considers the addition of corticosteroids to reduce cerebral edema and improve cognitive function. This decision reflects careful clinical reasoning, balancing the potential benefits of symptom relief against the risks of exacerbating her hyperglycemia and other side effects.

In tandem with these interventions, the team continues to monitor her serum calcium levels closely, as hypercalcemia can further contribute to her altered mental status. With ongoing intravenous hydration and the initiation of bisphosphonate therapy, her calcium levels begin to trend downward, providing some reassurance. However, the discovery of brain metastases signifies a critical juncture in her care, prompting discussions about the goals of treatment and the potential for integrating palliative care services to support her quality of life. This evolving situation underscores the need for a dynamic and responsive care plan, accommodating both the immediate and long-term aspects of her clinical needs.

Section 4

As the healthcare team continues to address the patient's complex condition, they notice a change in her status that requires immediate attention. Her mental status, while previously fluctuating, now shows more frequent episodes of confusion and disorientation. In addition, she begins to exhibit new-onset headaches and occasional visual disturbances, which were not present earlier in her clinical course. Recognizing these as potential signs of increased intracranial pressure, the team urgently reassesses her treatment plan.

The recent addition of corticosteroids has provided some cognitive improvement, yet her symptoms suggest that the cerebral edema might not be adequately controlled. A repeat MRI confirms the presence of increased edema around the metastatic lesions, necessitating an escalation in her steroid dosage. This decision is made with careful consideration, weighing the benefits of reducing intracranial pressure against the risk of further complicating her diabetes management. The team also discusses the possibility of radiation therapy as a targeted approach to shrink the lesions and provide more sustained relief from her neurological symptoms.

Simultaneously, her serum calcium levels continue to be monitored closely, with her latest lab results showing a level of 10.8 mg/dL, indicating a slight improvement but still warranting ongoing treatment. The bisphosphonate therapy, coupled with hydration, appears effective, yet the potential for recurrent hypercalcemia remains a concern. This evolving situation prompts the team to consider a more integrated approach to her care, incorporating both oncological treatments and supportive measures to enhance her quality of life. As discussions about her long-term care goals progress, the integration of palliative care services becomes a focal point, ensuring that her complex needs are met with compassion and comprehensive support.

Section 5

As the healthcare team monitors the patient's response to the adjusted treatment plan, they observe a notable change in her status. Her mental status shows intermittent improvement with the increased dosage of corticosteroids, but the episodes of confusion and disorientation persist, particularly in the evenings. Her blood pressure is elevated at 150/90 mmHg, a potential side effect of the steroid therapy, requiring careful monitoring and potential adjustment of her antihypertensive regimen. The patient also reports a persistent dull headache, rated 5 out of 10 on the pain scale, which temporarily subsides with analgesics but returns within a few hours. Vital signs reveal a pulse of 88 beats per minute, respiratory rate of 20 breaths per minute, and oxygen saturation at 95% on room air, suggesting stable respiratory function despite the neurological symptoms.

In the latest round of lab results, her serum glucose level is noted to be elevated at 250 mg/dL, reflecting the impact of corticosteroids on her diabetes management. The team initiates tighter glycemic control, adjusting her insulin regimen to mitigate the hyperglycemic effect. Her electrolytes remain stable, with a serum sodium level of 138 mmol/L and potassium at 4.0 mmol/L, indicating no immediate electrolyte imbalances. However, her serum calcium, while improved, remains at the upper limit of normal, necessitating continued vigilance.

Given these developments, the team discusses the potential need for more aggressive management of her cerebral edema. A multidisciplinary meeting is convened to evaluate the feasibility of initiating radiation therapy to address the metastatic lesions more directly. Additionally, the introduction of palliative care services is prioritized, aiming to address her symptom burden comprehensively and align her care with her long-term goals. This integrated approach seeks to balance the complexities of her oncological treatment with her overall quality of life, ensuring that her evolving needs are met with a compassionate and coordinated strategy.