skin breakddown - Nursing Case Study
Pathophysiology
• Primary mechanism: Pressure-induced ischemia - Sustained pressure over bony prominences disrupts blood flow, leading to tissue hypoxia and necrosis, which can result in pressure ulcers.
• Secondary mechanism: Moisture-associated skin damage - Prolonged exposure to moisture from sweat, urine, or feces weakens the skin barrier, making it more susceptible to breakdown and infection.
• Key complication: Infection risk - Compromised skin integrity from breakdown increases the risk of bacterial invasion, which can lead to cellulitis or systemic infection if not managed promptly.
Patient Profile
Demographics:
63-year-old female, retired school teacher
History:
• Key past medical history: Type 2 diabetes, hypertension, peripheral vascular disease
• Current medications: Metformin, Lisinopril, Aspirin
• Allergies: Penicillin
Current Presentation:
• Chief complaint: Non-healing ulcer on left heel
• Key symptoms: Redness, swelling, and moderate pain around the ulcer; occasional fever; increased fatigue
• Vital signs: Temperature 100.8°F, Blood Pressure 145/90 mmHg, Heart Rate 102 bpm, Respiratory Rate 20 breaths per minute
Section 1
As the healthcare team continues to monitor the 63-year-old female patient with a non-healing ulcer on her left heel, her condition presents a new concerning complication. During a routine wound assessment, the nurse observes increased purulent discharge and a foul odor emanating from the ulcer, suggesting a possible deepening infection. The surrounding skin displays signs of cellulitis, including increased warmth, erythema, and swelling that extends beyond the initial perimeter of the ulcer. The patient's left foot exhibits a slight fluctuation in edema, and she reports intensified pain, now rated 7/10, even at rest.
Laboratory results provide further insight into her deteriorating condition. A complete blood count reveals leukocytosis, with a white blood cell count elevated to 15,000/mm³, indicative of an inflammatory or infectious process. Her C-reactive protein level is also elevated at 45 mg/L, supporting the suspicion of an acute phase reaction. A wound culture is pending, but preliminary findings suggest the potential presence of a methicillin-resistant Staphylococcus aureus (MRSA) infection, raising the urgency for targeted antibiotic therapy.
Given these developments, the clinical team faces critical decisions regarding the patient's care plan. The need for appropriate antibiotic coverage is paramount, and adjustments in her current management are necessary to address both the infection and her underlying conditions, such as diabetes, which can impair wound healing. This progression emphasizes the importance of comprehensive care coordination, balancing infection control, pain management, and the monitoring of her systemic status to prevent further complications such as sepsis. The next steps will involve a multidisciplinary approach, including potential consultation with an infectious disease specialist and consideration of advanced wound care interventions.
Section 2
The patient's condition continues to evolve, highlighting the complexity of her clinical picture. Following the initial concerns of infection, the healthcare team initiates empiric antibiotic therapy with vancomycin, given the suspicion of MRSA involvement. However, within 48 hours, the patient exhibits a notable change in status. Her vital signs reveal a febrile state with a temperature of 101.5°F (38.6°C), tachycardia with a heart rate of 112 bpm, and a blood pressure reading of 100/60 mmHg, suggesting a potential systemic inflammatory response. The patient's respiratory rate has also increased to 24 breaths per minute, and her oxygen saturation has slightly decreased to 92% on room air, raising concerns about the potential development of sepsis.
The team conducts a thorough reassessment, noting that the erythema from the cellulitis has spread further up the leg, and the edema has become more pronounced. The patient's pain has escalated, now rated 8/10, prompting a reassessment of her pain management regimen. Repeat laboratory tests indicate a further rise in the white blood cell count to 18,000/mm³, alongside an increased C-reactive protein level of 60 mg/L, reinforcing the suspicion of an escalating infection. Blood cultures are obtained to evaluate for bacteremia, and the team considers the necessity of adjusting her antibiotic regimen based on the pending sensitivity results from the wound culture.
This change in the patient's status necessitates an urgent interdisciplinary meeting to discuss the next steps in her care. The possibility of an infectious disease consultation becomes more pressing, as does the consideration of advanced wound care techniques, such as negative pressure wound therapy or potential surgical intervention, should the infection continue to progress. The team must also address her diabetes management more aggressively, as hyperglycemia can exacerbate infection and impede healing. This unfolding scenario underscores the critical need for vigilant monitoring and timely intervention to prevent further complications, such as septic shock or systemic organ involvement. The patient's journey is at a pivotal juncture, requiring coordinated efforts to stabilize her condition and promote recovery.
Section 3
As the healthcare team convenes to address the patient's evolving condition, a new set of diagnostic results from the wound culture reveals methicillin-resistant Staphylococcus aureus (MRSA) as the causative organism, confirming the initial suspicion. This finding prompts an immediate review and adjustment of the antibiotic regimen. The team decides to continue vancomycin, given its efficacy against MRSA, but also considers adding a second antibiotic to broaden the spectrum and enhance the treatment response. Concurrently, the blood culture results return positive for MRSA, indicating that the infection has progressed to bacteremia. This critical development underscores the urgency of the situation, necessitating a reassessment of the patient's overall management plan.
In light of the new complications, the team shifts its focus to more aggressive interventions to prevent further deterioration. The patient's diabetes management is intensively reviewed, with adjustments made to her insulin regimen to achieve tighter glycemic control, recognizing the impact of hyperglycemia on infection progression and wound healing. Additionally, the patient's care plan now includes advanced wound care techniques, such as negative pressure wound therapy, to effectively manage the extensive cellulitis and promote tissue recovery. The interdisciplinary team, including an infectious disease specialist, collaborates closely to monitor the patient's response to these interventions, with the aim of stabilizing her condition and preventing the onset of septic shock.
Despite these efforts, the patient's status remains concerning. Her vital signs show persistent tachycardia at 115 bpm and hypotension with a blood pressure of 95/55 mmHg, alongside an increased oxygen requirement, now needing supplemental oxygen to maintain saturations above 94%. These indicators of potential systemic involvement prompt the team to consider additional measures, such as fluid resuscitation and potential vasopressor support, to maintain hemodynamic stability. The patient's journey through this critical phase highlights the complexity of managing systemic infections and the necessity for coordinated, multifaceted approaches to care. The team remains vigilant, prepared to adapt the treatment strategy as new information emerges, with the ultimate goal of guiding the patient safely through this challenging period.
Section 4
As the healthcare team continues to monitor the patient's response to the aggressive interventions, a change in her status becomes evident. During the morning assessment, the nurse notes that the patient's respiratory rate has increased to 28 breaths per minute, and she now exhibits signs of respiratory distress, including nasal flaring and use of accessory muscles. Her oxygen saturation has dropped to 90% despite being on 4 liters of supplemental oxygen via nasal cannula. These changes raise concerns about potential acute respiratory compromise, possibly due to developing complications such as acute respiratory distress syndrome (ARDS) secondary to the systemic infection and inflammation.
In addition to the respiratory concerns, the patient's renal function tests reveal a concerning trend. Her serum creatinine has increased from 1.0 mg/dL to 1.8 mg/dL over the past 24 hours, indicating possible acute kidney injury (AKI), likely exacerbated by hypotension and the systemic inflammatory response. Furthermore, her urine output has decreased to 20 mL/hour, reinforcing the suspicion of renal impairment. These findings prompt the interdisciplinary team to re-evaluate the patient's fluid status and consider adjusting fluid resuscitation efforts, while also discussing the potential need for renal protective strategies and close monitoring of her electrolyte balance.
The evolving clinical picture necessitates a recalibration of the management plan, with the team prioritizing stabilization of the patient's respiratory and renal function. Given the increased risk of developing septic shock, the team prepares to initiate vasopressor support if fluid resuscitation proves insufficient in maintaining adequate perfusion. This critical juncture emphasizes the importance of dynamic clinical reasoning, as the team strives to address the interconnected complications while remaining vigilant for further changes in the patient's condition. The goal is to achieve hemodynamic stability and respiratory support, allowing her to progress toward recovery without further escalation of care.
Section 5
As the healthcare team continues to monitor the patient, new diagnostic results reveal further insights into her deteriorating condition. A chest X-ray performed to investigate the respiratory distress shows bilateral infiltrates, raising the suspicion of acute respiratory distress syndrome (ARDS) becoming more pronounced. Concurrently, an arterial blood gas analysis indicates a mixed respiratory and metabolic acidosis, with a pH of 7.28, PaCO2 of 55 mmHg, and HCO3- of 18 mEq/L. These findings corroborate the clinical signs of respiratory compromise, necessitating prompt adjustments in her management plan.
In parallel, laboratory results show significant electrolyte imbalances, with potassium levels rising to 5.8 mEq/L and sodium levels dropping to 130 mEq/L. These abnormalities are likely linked to the acute kidney injury and systemic inflammatory response. The elevated potassium level, in particular, poses an immediate threat of cardiac dysrhythmias, prompting the team to initiate measures to stabilize her electrolyte balance. Calcium gluconate is administered to protect the heart, alongside insulin and glucose to help shift potassium intracellularly, and additional interventions such as sodium polystyrene sulfonate are considered to enhance potassium elimination.
Given the new complications, the interdisciplinary team convenes to re-evaluate the patient's treatment strategy. They decide to escalate respiratory support by transitioning from nasal cannula to high-flow oxygen therapy, aiming to improve her oxygenation and reduce the work of breathing. Simultaneously, the nephrology team assesses the need for renal replacement therapy if her urine output and creatinine levels do not improve with conservative management. This evolving scenario underscores the complexity of her condition, highlighting the necessity of continuous clinical reasoning and vigilant monitoring to preempt further complications while working towards stabilizing her critical systems.