cancer - Nursing Case Study
Pathophysiology
• Primary mechanism: Uncontrolled cell division - Cancer arises when cells lose regulatory control over the cell cycle, leading to continuous and unchecked proliferation. This is often due to mutations in oncogenes (genes that drive cell growth) and tumor suppressor genes (genes that normally inhibit cell division).
• Secondary mechanism: Evasion of apoptosis - Cancer cells develop the ability to evade programmed cell death, allowing them to survive despite genetic damage or unfavorable conditions. This is often achieved through mutations in genes that regulate apoptosis pathways, such as the p53 gene.
• Key complication: Metastasis - Cancer cells acquire the ability to invade neighboring tissues and spread to distant organs, complicating treatment and significantly impacting prognosis. This process involves changes in cell adhesion, increased mobility, and the ability to degrade extracellular matrix components.
Patient Profile
Demographics:
52-year-old female, office manager
History:
• Key past medical history: Hypertension, Type 2 Diabetes
• Current medications: Metformin, Lisinopril, Atorvastatin
• Allergies: Penicillin
Current Presentation:
• Chief complaint: Persistent cough and chest pain
• Key symptoms: Fatigue, shortness of breath, unintentional weight loss, night sweats
• Vital signs: Blood pressure 145/90 mmHg, heart rate 110 bpm, respiratory rate 24 breaths/min, temperature 100.4°F
Section 1
Following the initial presentation, the healthcare team ordered a series of diagnostic tests, including a chest X-ray and a CT scan, to further investigate the cause of the patient's symptoms. The results revealed a mass in the left lower lobe of the lung, with irregular borders and signs suggestive of malignant characteristics. Additionally, there were enlarged lymph nodes in the mediastinal region. A biopsy was performed, and histopathological analysis confirmed non-small cell lung cancer (NSCLC). Laboratory tests showed elevated levels of carcinoembryonic antigen (CEA), a tumor marker often associated with lung cancer, and mild anemia likely due to the chronic disease process.
The patient's condition began to show signs of further complexity with the onset of pleural effusion, as evidenced by dullness to percussion and decreased breath sounds on the left side during a physical exam. A thoracentesis was performed to relieve symptoms and analyze the pleural fluid, which revealed malignant cells, indicating pleural involvement in the cancer's spread. Clinically, her respiratory status remained compromised; she continued to experience dyspnea and required supplemental oxygen to maintain adequate oxygen saturation levels.
In light of these findings, the oncologist recommended a multidisciplinary approach, including initiation of chemotherapy to target systemic disease. The patient was also referred to a pulmonologist for ongoing management of respiratory symptoms and to a nutritionist to address unintentional weight loss and maintain nutritional status. The healthcare team emphasized the importance of regular monitoring of blood glucose levels, given her diabetes, and close management of hypertension to minimize additional cardiovascular risks during treatment. As the patient's journey unfolded, the focus shifted to balancing cancer management with her chronic conditions, requiring careful coordination among her healthcare providers.
Section 2
As the multidisciplinary team began implementing the treatment plan, the patient's response to chemotherapy was closely monitored. After the first cycle, the patient reported increased fatigue and nausea, common side effects of the chemotherapeutic agents. Her vital signs remained stable; however, her blood pressure was noted to be slightly elevated at 150/90 mmHg, and her heart rate was 88 beats per minute. Her blood glucose levels were also fluctuating more than usual, with occasional readings exceeding 200 mg/dL, indicating the need for potential adjustments in her diabetes management. The team adjusted her antiemetic medication to better control the nausea and initiated a plan for more frequent monitoring of her blood glucose and blood pressure levels.
Despite these challenges, there was a modest improvement in the patient's respiratory status. Her dyspnea improved slightly, and she was able to reduce her supplemental oxygen requirement. However, a follow-up chest X-ray demonstrated a slight increase in the pleural effusion, prompting another thoracentesis to prevent further respiratory compromise. The pulmonologist recommended continued surveillance of the effusion and potential pleurodesis if the effusions persisted.
In parallel, the nutritionist's intervention began to show positive effects, as the patient managed to stabilize her weight by adhering to a high-calorie, nutrient-dense diet. However, she continued to experience occasional episodes of anorexia. Regular consultations with the nutritionist were maintained to optimize her nutritional intake and support her immune function during chemotherapy. As the patient navigated these complexities, the healthcare team remained vigilant, ready to adapt the treatment plan as needed to address evolving challenges and support her overall well-being.
Section 3
As the treatment progressed into the second cycle of chemotherapy, the patient's condition presented new challenges. During a routine follow-up, the patient reported increased palpitations and intermittent dizziness, prompting further investigation. Upon assessment, her vital signs revealed a blood pressure of 160/95 mmHg and a heart rate of 102 beats per minute. An electrocardiogram showed sinus tachycardia but no acute ischemic changes. Concurrently, lab results indicated a hemoglobin level of 9.5 g/dL, a decrease from previous levels, suggesting the development of anemia, likely secondary to chemotherapy. The elevated blood glucose levels persisted, with new readings frequently exceeding 220 mg/dL, necessitating a reassessment of her diabetes management plan.
The healthcare team decided to consult a cardiologist to evaluate the cardiovascular symptoms and consider potential interventions to manage the hypertension and tachycardia. Adjustments were made to the patient's antihypertensive regimen, and a beta-blocker was introduced to help control her heart rate. The endocrinologist recommended modifications to her insulin regimen in response to the hyperglycemia, with increased monitoring to prevent further complications. Additionally, a blood transfusion was considered to address the anemia if her hemoglobin levels continued to decline, with plans for close monitoring of her complete blood count.
The patient's ability to manage these new symptoms and the adjustments in her treatment plan would be pivotal in maintaining her progress. The team emphasized the importance of patient education regarding symptom monitoring and the significance of medication adherence. Regular multidisciplinary meetings were scheduled to ensure a cohesive approach in managing the complexities of her condition, focusing on optimizing her quality of life while continuing to address the cancer treatment goals. As the patient navigated these developments, the team prepared to respond to further changes in her status, anticipating potential challenges that might arise in subsequent treatment cycles.
Section 4
As the patient's treatment continued, the healthcare team closely monitored her response to the newly implemented interventions. During a follow-up visit two weeks after the adjustments, the patient reported a mild improvement in palpitations and dizziness. Her blood pressure had decreased to 145/88 mmHg, and her heart rate was now 88 beats per minute, indicating a positive response to the introduction of the beta-blocker. However, she still experienced occasional episodes of fatigue and shortness of breath. A repeat electrocardiogram confirmed the absence of acute ischemic changes, providing reassurance that the sinus tachycardia was being managed effectively.
Despite these improvements, new complications emerged. The patient's hemoglobin levels continued to decline, reaching 8.7 g/dL, prompting the team to proceed with the planned blood transfusion. Additionally, her blood glucose levels remained uncontrolled, with readings often above 250 mg/dL despite adjustments to her insulin regimen. This hyperglycemia raised concerns about the potential risk of diabetic ketoacidosis, necessitating further evaluation and adjustments by the endocrinologist. The patient's kidney function tests also showed a slight increase in creatinine levels, suggesting the need to monitor for chemotherapy-induced nephrotoxicity.
These developments required the healthcare team to reassess their approach, focusing on balancing the management of her cancer with the mitigation of these side effects. The multidisciplinary team deliberated on strategies to optimize her treatment, including potential changes in chemotherapy dosage or schedule. They also reinforced the importance of patient education, emphasizing the need for vigilant symptom tracking and adherence to the revised treatment plan. As the team prepared for the next chemotherapy cycle, they remained vigilant for any additional complications that might arise, understanding that the patient's resilience and engagement in her care were crucial to navigating these challenges successfully.
Section 5
In the subsequent week following the reassessment of the patient's treatment plan, the patient encountered a new complication. She began experiencing increased peripheral edema, particularly noticeable in her lower extremities, accompanied by a sudden weight gain of 3 kilograms over two days. During her visit to the clinic, her vital signs showed a blood pressure of 150/92 mmHg and a heart rate of 90 beats per minute. Physical examination confirmed bilateral pitting edema up to the mid-calf level. Additionally, there was a notable reduction in her urine output, raising concerns about worsening renal function or potential heart failure exacerbation.
The healthcare team promptly conducted new diagnostic tests, including a comprehensive metabolic panel, which revealed further deterioration in kidney function, with a serum creatinine level now elevated to 2.1 mg/dL from the previous 1.8 mg/dL. Serum electrolytes showed mild hyponatremia, with sodium levels dropping to 132 mmol/L. Given these findings, the team suspected that the combination of chemotherapy and recent changes in her medication regimen might be contributing to these renal and cardiovascular complications. An echocardiogram was ordered to assess cardiac function, and a nephrology consult was requested to evaluate potential nephrotoxicity and guide further management.
Recognizing the complexity of her condition, the team prioritized immediate adjustments to her treatment. They considered reducing the chemotherapy dosage and temporarily holding nephrotoxic agents while optimizing her fluid balance through careful diuretic management. Patient education was emphasized, particularly regarding monitoring fluid intake and recognizing early signs of heart failure or worsening kidney function. The patient's active participation in her care plan was encouraged, ensuring she understood the importance of reporting any new symptoms promptly. As the team prepared to adjust her treatment regimen, they remained alert to the possibility of additional complications, understanding that a coordinated and dynamic approach was essential in managing her multifaceted clinical picture.