Cervical Cancer - Nursing Case Study
Pathophysiology
• Primary mechanism: Persistent infection with high-risk human papillomavirus (HPV), especially types 16 and 18, leads to changes in cervical cells. These viral infections disrupt normal cell cycle control, causing cells to grow and divide uncontrollably.
• Secondary mechanism: Integration of HPV DNA into the host cell genome further disrupts tumor suppressor genes like p53 and retinoblastoma protein (Rb), promoting the development of precancerous lesions and eventually invasive cancer.
• Key complication: If untreated, these cellular changes can progress from cervical intraepithelial neoplasia (CIN) to invasive cervical cancer, potentially leading to metastasis and complications such as pelvic pain, vaginal bleeding, and impaired reproductive function.
Patient Profile
Demographics:
45, female, office administrator
History:
• Key past medical history: No significant medical history
• Current medications: Oral contraceptive pills
• Allergies: None
Current Presentation:
• Chief complaint: Routine screening
• Key symptoms: Asymptomatic
• Vital signs: Blood pressure 120/80 mmHg, Heart rate 72 bpm, Respiratory rate 16 breaths per minute, Temperature 98.6°F
Section 1
Initial Assessment Findings:
During a routine screening, the patient underwent a Pap smear, which revealed atypical squamous cells of undetermined significance (ASC-US). Further testing with an HPV DNA test confirmed the presence of high-risk HPV types 16 and 18. As a result, a colposcopy was performed, which showed cervical intraepithelial neoplasia grade 1 (CIN 1). The findings indicate early-stage changes in the cervical cells, associated with HPV infection, but no evidence of invasive cancer at this point.
The patient's vital signs remain stable with blood pressure at 120/80 mmHg, heart rate at 72 bpm, respiratory rate at 16 breaths per minute, and temperature at 98.6°F. She is asymptomatic and reports no discomfort, pelvic pain, or unusual bleeding. The patient expresses concern about the implications of the findings but is reassured by the healthcare team that CIN 1 is a low-grade lesion and often regresses spontaneously without treatment. The focus is on monitoring and consistent follow-up to ensure that any progression can be addressed promptly.
The nursing team educates the patient on the importance of maintaining regular screenings and follow-up appointments to monitor the condition closely. The patient is advised about lifestyle modifications that could support immune function, such as smoking cessation if applicable, maintaining a healthy diet, and managing stress. The plan includes scheduling a follow-up colposcopy in six months to reassess the cervical lesions and determine if they have persisted, regressed, or progressed, guiding further management decisions.
Section 2
Six months later, the patient returns for her scheduled follow-up appointment. She reports feeling generally well, with no new symptoms such as unusual bleeding or pelvic pain. The patient has adhered to the recommended lifestyle changes, including quitting smoking and incorporating a balanced diet rich in fruits and vegetables. Her vital signs remain stable, with a blood pressure of 118/76 mmHg, heart rate of 70 bpm, respiratory rate of 16 breaths per minute, and temperature at 98.4°F.
A repeat colposcopy is performed, and the results show that the cervical intraepithelial neoplasia has decreased in severity, indicating regression of the CIN 1 lesions. The healthcare team is encouraged by these findings, as they suggest that the patient's immune system is effectively managing the HPV infection, consistent with the natural course of low-grade cervical lesions. The patient's Pap smear results are normal, further supporting the positive trend.
The nursing team continues to emphasize the importance of regular follow-up appointments and screenings to the patient. They discuss the potential for future HPV vaccinations to prevent new infections, although the patient has already been exposed to high-risk HPV types. The patient expresses relief and gratitude for the supportive care and education provided, reinforcing her commitment to ongoing health monitoring. The plan includes another follow-up in a year to ensure continued regression or stability of the cervical changes, with reassurance that any new symptoms should prompt an immediate visit.
Section 3
Six months after the reassuring follow-up visit, the patient attends her next scheduled appointment. During the initial assessment, the nursing team notes that the patient continues to report feeling generally well, with no significant new symptoms. However, she mentions experiencing occasional mild discomfort during intercourse, which she describes as intermittent and not severe enough to disrupt her daily activities. Her commitment to a healthy lifestyle remains steadfast, as she continues to abstain from smoking and maintains a balanced diet. Vital signs are stable: blood pressure is 116/74 mmHg, heart rate is 72 bpm, respiratory rate is 16 breaths per minute, and temperature is 98.6°F.
A comprehensive physical examination is performed, and the findings are largely unremarkable. However, a pelvic exam reveals slight cervical tenderness, prompting the healthcare team to conduct a more thorough investigation. A repeat colposcopy and a Pap smear are ordered to assess any changes in the cervical epithelium. The results show persistent regression of the previous CIN 1 lesions, but a small area of inflammation is noted, which is attributed to the mild discomfort the patient reported. Lab tests indicate normal white blood cell counts, suggesting no active infection, and HPV testing remains positive for the previously identified high-risk types.
The nursing team uses these findings as an opportunity to reinforce the importance of regular screenings and to educate the patient about potential benign causes of her symptoms, such as hormonal changes or minor cervical irritation. They emphasize that while the inflammation appears minor, persistence or worsening of symptoms should be monitored closely. The patient is reassured that the current findings do not indicate significant progression and that the plan remains focused on surveillance and symptom management. A follow-up appointment is scheduled for six months, with instructions for the patient to return sooner if symptoms intensify or new ones arise.
Section 4
Three months after the last visit, the patient returns to the clinic, as she has started to experience a change in her symptoms. She reports that the mild discomfort during intercourse has become more frequent, though still not severe. Additionally, she mentions occasional spotting post-intercourse, which is a new symptom. However, she continues to feel generally well with no other significant symptoms. Vital signs remain stable with blood pressure at 118/76 mmHg, heart rate at 74 bpm, respiratory rate at 16 breaths per minute, and temperature at 98.4°F.
Given these new symptoms, the nursing team conducts a more detailed pelvic examination. Upon inspection, they note erythema and mild swelling of the cervical tissue. There are no signs of active bleeding, but the cervix appears slightly more friable than before. A decision is made to perform a biopsy of the inflamed area to rule out any progression of cervical intraepithelial neoplasia or other pathological changes. Lab tests are repeated, showing a slight increase in inflammatory markers, but still within normal limits, and the patient's HPV status remains unchanged.
The nursing team uses this opportunity to discuss with the patient potential causes of the new symptoms, such as minor trauma or increased vascular fragility of the cervical tissue. They emphasize the importance of monitoring symptoms and adhering to follow-up care. The patient is advised to avoid potential irritants and to use lubricants during intercourse to minimize discomfort. A follow-up appointment is scheduled for four weeks after the biopsy results are anticipated, with instructions to report any significant changes in symptoms immediately.
Section 5
Four weeks later, the patient returns to the clinic for her scheduled follow-up appointment to review the biopsy results. She reports adhering to the care instructions given and using lubricants during intercourse, which has helped reduce discomfort. She has not experienced any new symptoms, and the post-intercourse spotting has decreased slightly. Her vital signs remain stable with blood pressure at 116/78 mmHg, heart rate at 72 bpm, respiratory rate at 16 breaths per minute, and temperature at 98.2°F.
The biopsy results indicate low-grade cervical intraepithelial neoplasia (CIN 1), which is consistent with early-stage cervical changes and not indicative of invasive cancer. The nursing team explains that this condition often resolves spontaneously but will require regular monitoring to ensure it does not progress. They educate the patient about the importance of routine Pap smears and HPV testing as part of her ongoing care plan. Additionally, they discuss lifestyle modifications, such as smoking cessation and maintaining a healthy immune system, which can help her body clear the HPV infection more effectively.
The patient expresses relief upon learning that the findings are not immediately concerning but acknowledges the need for vigilance in her follow-up care. She is scheduled for another examination in six months, with instructions to continue monitoring her symptoms and report any significant changes. The nursing team provides reassurance and resources for support, including information on local cervical cancer support groups, as she navigates the next steps of her care journey.