infant bronchiolitis - Nursing Case Study

Pathophysiology

• Primary mechanism: Viral infection, predominantly by Respiratory Syncytial Virus (RSV), leads to inflammation and necrosis of epithelial cells lining the bronchioles, causing airway obstruction.

• Secondary mechanism: Edema and increased mucus production further narrow the bronchioles, impairing airflow and oxygen exchange, and leading to respiratory distress in infants.

• Key complication: Air trapping and atelectasis may occur due to obstruction, resulting in hypoxia and, in severe cases, respiratory failure, necessitating supportive interventions.

Patient Profile

Demographics:

6 months old, female, n/a

History:

• Key past medical history: Born prematurely at 35 weeks, history of mild eczema

• Current medications: None

• Allergies: No known drug allergies

Current Presentation:

• Chief complaint: Difficulty breathing and wheezing

• Key symptoms: Cough, nasal congestion, decreased feeding, irritability, mild fever, increased work of breathing

• Vital signs: Temperature 38.5°C, heart rate 160 bpm, respiratory rate 60 breaths/min, oxygen saturation 90% on room air

Section 1

As the medical team conducts an initial assessment, the infant, named Sophia, is visibly in respiratory distress. Physical examination reveals nasal flaring, intercostal retractions, and audible wheezing upon auscultation. The increased work of breathing is evident, with her respiratory rate climbing to 65 breaths per minute. Despite supplemental oxygen via nasal cannula, Sophia's oxygen saturation remains suboptimal at 92%. Her skin is slightly mottled, and she appears lethargic, which raises concern for potential hypoxemia.

The decision is made to perform a chest X-ray to further evaluate the extent of her respiratory compromise and to rule out additional complications such as pneumonia or atelectasis. The imaging reveals diffuse bilateral infiltrates consistent with viral bronchiolitis, but also highlights areas of hyperinflation and patchy atelectasis in the right lower lobe, suggesting significant air trapping. These findings correlate with her current symptoms and indicate a worsening of her condition, prompting the healthcare team to consider more aggressive interventions.

New blood work is ordered to assess her overall status, including a complete blood count (CBC) and blood gas analysis. The CBC shows a slight elevation in white blood cell count, consistent with an acute viral infection, while the blood gas reveals a mild respiratory acidosis with a pH of 7.30 and an elevated pCO2 of 48 mmHg. This data reinforces the need for close monitoring and consideration of potential escalation to non-invasive positive pressure ventilation to support her breathing and prevent further deterioration. The team prepares to discuss these findings and potential treatment adjustments with Sophia's parents, ensuring they are informed and involved in the decision-making process.

Section 2

As the team discusses the new diagnostic results and potential interventions with Sophia's parents, Sophia's condition takes a concerning turn. Her respiratory distress escalates, marked by an increased respiratory rate of 72 breaths per minute, and her oxygen saturation drops further to 89% despite the current supplemental oxygen. Her lethargy progresses into a decreased level of responsiveness, and she has developed a slight cyanosis around her lips and fingertips, indicating worsening hypoxemia. These changes prompt an immediate reassessment and a shift in the team's focus towards more aggressive respiratory support.

Recognizing the risk of respiratory failure, the decision is made to initiate non-invasive positive pressure ventilation (NIPPV) to improve Sophia's ventilation and oxygenation. The team carefully explains the urgency and the rationale for this intervention to Sophia's parents, emphasizing the goal of stabilizing her breathing and preventing the need for intubation. With the application of NIPPV, Sophia's respiratory effort begins to ease, and her oxygen saturation improves marginally to 94%. However, her work of breathing remains significant, and her blood gas is re-evaluated, revealing a persistent respiratory acidosis with a pH of 7.28 and a pCO2 of 50 mmHg.

As Sophia's condition stabilizes momentarily, the healthcare team remains vigilant, aware of the potential for further complications such as dehydration or secondary bacterial infection, given her ongoing respiratory distress and lethargy. They initiate an intravenous line for fluid support and consider the need for empirical antibiotic coverage due to her deteriorating clinical picture. The team prepares to conduct regular assessments and continuous monitoring, understanding that the next steps in Sophia's care will depend on her response to this critical intervention and any emerging complications.

Section 3

The healthcare team closely monitors Sophia's response to the NIPPV, observing her vital signs and overall condition. Initially, her oxygen saturation stabilizes at 94%, but her heart rate remains elevated at 160 beats per minute, reflecting ongoing stress and possible dehydration. Her respiratory rate decreases slightly to 66 breaths per minute, but her work of breathing remains labored, indicated by the use of accessory muscles and nasal flaring. These signs suggest that while NIPPV is providing some relief, it may not be sufficient to address her underlying respiratory and metabolic needs.

A repeat chest X-ray is ordered to rule out any underlying complications such as pneumonia or atelectasis that could be contributing to her condition. The results show diffuse bilateral infiltrates consistent with viral bronchiolitis, but no evidence of focal consolidation or pleural effusion. This finding reinforces the need for continued respiratory support and careful monitoring for potential secondary bacterial infection. Her complete blood count reveals a mild leukocytosis, with a white blood cell count of 13,000/mm³, suggesting a possible evolving infection.

In light of these findings, the team decides to initiate broad-spectrum antibiotics as a precautionary measure while awaiting further culture results. Additionally, they increase her intravenous fluid rate to address potential dehydration and support her cardiovascular status. The team remains vigilant, conducting frequent reassessments to detect any signs of worsening respiratory failure or emerging complications. As they navigate this critical phase, they keep Sophia's parents informed, explaining each step in the evolving care plan and encouraging their involvement in decision-making. This approach ensures that the team is prepared to adjust interventions promptly, aiming to stabilize Sophia and prevent further deterioration.

Section 4

As the team continues to monitor Sophia, they observe a change in her status that prompts further evaluation. Over the next 12 hours, Sophia's respiratory rate increases to 72 breaths per minute, and her oxygen saturation drops to 90% despite the ongoing NIPPV support. Her heart rate remains elevated at 165 beats per minute, and she exhibits increased irritability, which could be indicative of hypoxemia or discomfort. These changes suggest a potential deterioration in her respiratory function, necessitating immediate clinical attention and reassessment of her treatment plan.

A follow-up arterial blood gas analysis reveals a pH of 7.32, a PaCO2 of 55 mmHg, and a PaO2 of 65 mmHg, indicating respiratory acidosis with hypoxemia. This finding supports the clinical impression that Sophia is experiencing worsening respiratory failure. Given these results, the healthcare team discusses the possibility of escalating her respiratory support to invasive mechanical ventilation to better manage her gas exchange and relieve her respiratory muscles. Additionally, they consider adjusting her antibiotic regimen based on preliminary culture findings, which indicate the presence of a potential bacterial superinfection.

The team communicates these developments to Sophia's parents, ensuring they understand the rationale for potential intubation and the importance of addressing the suspected bacterial infection. They emphasize the need for close monitoring and frequent reassessment to guide further interventions. This transparent communication helps maintain the family's trust and involvement in Sophia's care, as the team works to stabilize her condition and prevent further complications. The clinical team's careful consideration and response to Sophia's evolving needs underscore the complexity of managing infant bronchiolitis with complications, highlighting the importance of timely intervention and comprehensive care.

Section 5

As the team proceeds with the decision to intubate Sophia, they prepare to optimize her care prior to the procedure. In the interim, they initiate a trial of a higher level of non-invasive support with increased positive end-expiratory pressure (PEEP) to see if it can adequately improve her ventilation. Despite these efforts, Sophia's oxygen saturation continues to hover around 88-90%, and her respiratory distress remains significant. Her breathing becomes increasingly labored, with pronounced nasal flaring and intercostal retractions, indicating that her current respiratory support is insufficient.

In conjunction with the respiratory support adjustments, the team examines the preliminary culture results more closely. They identify Haemophilus influenzae as the likely pathogen, which necessitates a tailored antibiotic regimen. The team initiates intravenous ceftriaxone, altering her previous antibiotic therapy to better target this organism. This decision is made swiftly to address the bacterial superinfection that may be exacerbating her respiratory condition.

Throughout these interventions, Sophia's vital signs are closely monitored. Her heart rate decreases slightly to 160 beats per minute, but her respiratory rate remains elevated at 70 breaths per minute. Her blood pressure is stable at 85/50 mmHg, and her capillary refill time is within normal limits, suggesting adequate perfusion despite her respiratory compromise. The team remains vigilant, ready to intubate Sophia if her clinical status does not improve with the current measures. The situation highlights the critical nature of timely reassessment and the importance of dynamic clinical reasoning in managing the complexities of her condition.