Hypertension - Nursing Case Study

Pathophysiology

• Primary mechanism: Increased peripheral resistance - Hypertension often arises from the narrowing or stiffening of blood vessels, which increases resistance to blood flow. This resistance requires the heart to exert more force to circulate blood, leading to elevated blood pressure.

• Secondary mechanism: Renin-angiotensin-aldosterone system (RAAS) activation - Overactivity of RAAS results in vasoconstriction and sodium retention, which increase blood volume and pressure. Angiotensin II, a potent vasoconstrictor, and aldosterone contribute to these effects, exacerbating hypertension.

• Key complication: Target organ damage - Persistent hypertension strains the cardiovascular system, potentially leading to complications such as left ventricular hypertrophy, renal damage, and increased risk of stroke. Early intervention can mitigate these risks by controlling blood pressure.

Patient Profile

Demographics:

55-year-old male, office worker

History:

• Key past medical history: Hypertension diagnosed 5 years ago, family history of cardiovascular disease

• Current medications: Lisinopril 20 mg daily, Hydrochlorothiazide 25 mg daily

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Persistent headaches and occasional dizziness

• Key symptoms: Fatigue, shortness of breath on exertion, occasional chest discomfort

• Vital signs: Blood pressure 160/100 mmHg, heart rate 92 bpm, respiratory rate 18 breaths per minute, temperature 98.6°F

Section 1

New Diagnostic Results:

A series of diagnostic tests were conducted to further evaluate the patient's hypertensive status and investigate potential organ damage. The laboratory results revealed elevated serum creatinine levels at 1.8 mg/dL, indicating possible renal impairment, a common complication in long-standing hypertension. Additionally, the patient's lipid profile showed elevated LDL cholesterol at 160 mg/dL and triglycerides at 200 mg/dL, both of which increase cardiovascular risk. An echocardiogram was performed, demonstrating mild left ventricular hypertrophy, suggesting that the heart muscle has thickened in response to the increased workload caused by hypertension.

The patient's electrocardiogram (ECG) showed signs of left atrial enlargement, which, along with the echocardiogram findings, supports the presence of cardiac remodeling due to chronic high blood pressure. This structural change is concerning as it can predispose the patient to arrhythmias and heart failure if not addressed. Blood tests also revealed slightly elevated fasting blood glucose levels at 110 mg/dL, raising suspicion of possible insulin resistance, a condition often associated with hypertension and increased cardiovascular risk.

These diagnostic findings underscore the need for a comprehensive management plan that not only targets blood pressure control but also addresses the metabolic and cardiovascular risks identified. The healthcare team must now consider adjustments to the patient's current antihypertensive regimen, perhaps integrating medications that offer renal protection and cardiovascular benefits. Lifestyle interventions focusing on diet, exercise, and weight management should also be reinforced to mitigate these risks and prevent further complications. This approach aims to prevent the progression of renal and cardiac damage, enhance quality of life, and decrease the likelihood of acute events such as myocardial infarction or stroke.

Section 2

Change in Patient Status:

Following the implementation of a comprehensive management plan focusing on blood pressure control, metabolic risk reduction, and lifestyle modification, the patient initially showed signs of improvement. Blood pressure readings over the past few weeks averaged around 135/85 mmHg, a significant reduction from previous levels. The patient adhered to dietary recommendations, reducing sodium intake and incorporating more fruits and vegetables, and began a regular walking routine. However, during a routine follow-up visit, the patient reported experiencing increased fatigue, occasional palpitations, and mild swelling in the lower extremities.

A physical examination revealed bilateral pitting edema in the ankles. Auscultation of the heart showed a regular rhythm but with a new S4 heart sound, suggestive of decreased ventricular compliance. The patient's weight had increased by 3 kg since the last visit, raising concerns about fluid retention. Repeat blood tests showed a further increase in serum creatinine to 2.1 mg/dL, indicating worsening renal function. Additionally, the patient's fasting blood glucose had risen to 120 mg/dL, pointing toward advancing insulin resistance.

These changes in the patient's status highlight the need for reassessment of the current treatment regimen. The worsening renal function and onset of symptoms such as edema and palpitations suggest the possibility of early heart failure or exacerbation of existing cardiac issues. The healthcare team must consider adjusting medications, possibly adding or optimizing diuretics to manage fluid overload while ensuring renal protection. Continuous monitoring and patient education on recognizing early signs of complications will be crucial to prevent further deterioration and ensure a more stabilized cardiovascular and renal profile. This scenario requires careful clinical reasoning to balance the benefits and risks of treatment adjustments, aiming to improve patient outcomes and prevent acute complications.

Section 3

Following the identification of increased fatigue, palpitations, and lower extremity edema, the healthcare team proceeded with additional diagnostic evaluations to determine the underlying cause of the patient's deteriorating condition. An echocardiogram was performed, revealing left ventricular hypertrophy and mild diastolic dysfunction, corroborating the suspicion of compromised cardiac function. These findings, in conjunction with the newly detected S4 heart sound, suggest the development of heart failure with preserved ejection fraction (HFpEF), a condition often associated with hypertension.

Further laboratory tests indicated a slight elevation in B-type natriuretic peptide (BNP) levels at 150 pg/mL, supporting the presence of heart strain and fluid overload. The patient's electrolytes were also reassessed, showing a potassium level of 5.2 mEq/L, which, while slightly elevated, requires careful monitoring given the potential need for diuretic therapy. The renal function tests confirmed the previously noted decline, with a glomerular filtration rate (GFR) calculated at 45 mL/min/1.73m², highlighting moderate chronic kidney disease likely exacerbated by the current cardiovascular strain.

Given these new diagnostic results, the healthcare team faces the challenge of fine-tuning the treatment plan to address both cardiac and renal issues. This involves evaluating the potential introduction of a low-dose loop diuretic to alleviate fluid retention while monitoring renal function closely to prevent further deterioration. Additionally, the consideration of an angiotensin receptor-neprilysin inhibitor (ARNI) may be warranted to improve cardiac outcomes, though this requires cautious assessment given the patient's renal status. The integration of these interventions aims to stabilize the patient's condition, emphasizing the importance of clinical reasoning in balancing cardiac and renal health to avert further complications.

Section 4

As the healthcare team initiated the adjusted treatment plan, the patient was started on a low-dose loop diuretic to manage fluid retention, with careful monitoring of renal function and electrolyte balance. Within a few days, there was a noticeable reduction in lower extremity edema, and the patient reported a slight improvement in breathing and fatigue levels. Vital signs were closely tracked, showing a blood pressure of 138/84 mmHg, heart rate of 78 beats per minute, and respiratory rate of 18 breaths per minute. Despite these improvements, a follow-up laboratory test indicated that the patient's potassium level had risen further to 5.5 mEq/L, raising concerns about hyperkalemia, which requires immediate attention to prevent cardiac arrhythmias.

In light of the elevated potassium levels, the healthcare team reevaluated the medication regimen. The decision was made to adjust the dosage of the loop diuretic and temporarily hold any potassium-sparing medications, while increasing dietary education to limit potassium intake. Additionally, the team considered introducing a sodium polystyrene sulfonate to facilitate potassium excretion. Despite these interventions, the patient's renal function showed a slight decline, with a GFR further reduced to 42 mL/min/1.73m², reinforcing the delicate balance required in managing the patient's cardiac and renal conditions.

These developments necessitated a multidisciplinary team approach, engaging with a renal specialist to optimize the management of chronic kidney disease alongside heart failure management. The clinical team remained vigilant for potential new complications, understanding that the patient's condition required ongoing adjustments and monitoring to prevent further deterioration. The next steps in the patient's care plan focused on continued assessment of electrolyte levels, renal function, and hemodynamic stability, aiming to achieve a stable balance while mitigating risks associated with heart failure and chronic kidney disease.

Section 5

As the healthcare team continued to monitor the patient, a change in status was observed that prompted immediate attention. The patient began experiencing mild chest discomfort and increased episodes of palpitations. Vital signs revealed a blood pressure of 145/90 mmHg, a heart rate of 102 beats per minute, and a respiratory rate of 20 breaths per minute. These findings suggested a possible exacerbation of heart failure or the development of cardiac arrhythmias, potentially linked to the unresolved hyperkalemia and declining renal function.

A 12-lead ECG was performed, showing signs of peaked T waves, which are indicative of hyperkalemia. In response, the clinical team prioritized stabilizing the patient's cardiac status while continuing to address electrolyte imbalances. The dosage of sodium polystyrene sulfonate was adjusted, and the patient was placed on a cardiac monitor for continuous observation. The renal specialist was consulted to further evaluate the possible need for renal replacement therapy, considering the progressive decrease in renal function and to prevent further cardiac complications.

The healthcare team recognized the need for a nuanced approach, balancing heart failure management with renal protection. The patient's care plan was adjusted to include close monitoring of cardiac and renal markers, with frequent reassessments to guide therapeutic decisions. This situation highlighted the complexity of managing comorbid conditions and underscored the importance of interdisciplinary collaboration. As the patient's journey progressed, the team remained vigilant for any new symptoms or lab changes that might necessitate further intervention, emphasizing the critical need for ongoing assessment and adaptation of the treatment strategy.