Pediatric Kidney Disease - Nursing Case Study

Pathophysiology

• Primary mechanism: Congenital Abnormalities - Many pediatric kidney diseases originate from congenital anomalies, such as renal dysplasia or obstructive uropathy, leading to impaired nephron development and function, which can cause chronic kidney disease (CKD) early in life.

• Secondary mechanism: Glomerular Disorders - Conditions like nephrotic syndrome or glomerulonephritis involve damage to the glomeruli, the kidney's filtering units, resulting in proteinuria, hematuria, and progressive loss of renal function, contributing to CKD.

• Key complication: Hypertension - As kidney function declines, fluid and electrolyte imbalances can lead to hypertension, which further exacerbates kidney damage and increases the risk of cardiovascular issues, requiring careful management in pediatric patients.

Patient Profile

Demographics:

12-year-old female, student

History:

• Key past medical history: Diagnosed with stage 2 chronic kidney disease 6 months ago, recurrent urinary tract infections

• Current medications: Lisinopril, Ferrous sulfate, Vitamin D supplements

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Fatigue and swelling in legs

• Key symptoms: Decreased appetite, headaches, increased frequency of urination, occasional nausea

• Vital signs: Blood pressure 135/85 mmHg, heart rate 98 bpm, respiratory rate 22 breaths per minute, temperature 98.6°F

Section 1

Initial Assessment Findings:

Following the initial presentation, a thorough assessment of the 12-year-old patient was conducted to explore the underlying causes of her symptoms and guide the management of her chronic kidney disease. Upon physical examination, the patient was observed to have periorbital edema and bilateral pedal edema, suggesting fluid overload, possibly linked to her kidney dysfunction. Her blood pressure, noted at 135/85 mmHg, remained elevated, which is concerning given her age and the potential for further renal impairment. Auscultation revealed clear lung sounds, though her elevated respiratory rate of 22 breaths per minute might indicate compensatory mechanisms in response to her hypertensive state.

Laboratory results provided additional insights into her condition. Her serum creatinine level was elevated at 1.5 mg/dL, indicating a decline in kidney function from her previous baseline of 1.2 mg/dL. Blood urea nitrogen (BUN) was also elevated at 30 mg/dL, and her estimated glomerular filtration rate (eGFR) had decreased to 55 mL/min/1.73m², reinforcing the progression of her kidney disease. Urinalysis revealed proteinuria with a protein-to-creatinine ratio of 3.5 mg/mg, along with trace hematuria, suggesting ongoing glomerular damage. Her hemoglobin level was slightly low at 10.5 g/dL, consistent with anemia often seen in chronic kidney disease due to reduced erythropoietin production by the kidneys.

These findings highlight the need for a multidisciplinary approach to manage her condition effectively, focusing on controlling her hypertension and addressing her anemia and nutritional status. Adjustments to her current medication regimen, dietary modifications, and possibly the introduction of erythropoiesis-stimulating agents may be considered. Regular follow-up and close monitoring of her kidney function and blood pressure will be crucial in preventing further renal deterioration and mitigating the risk of cardiovascular complications. This assessment sets the stage for evaluating her response to these interventions and monitoring for any new complications that may arise.

Section 2

New Diagnostic Results

Two weeks after the initial assessment, the patient's condition was further investigated through additional diagnostic testing, aimed at gaining a deeper understanding of her chronic kidney disease progression and identifying any emerging complications. A repeat urinalysis showed a slight increase in proteinuria, with a protein-to-creatinine ratio now at 4.0 mg/mg, suggesting worsening glomerular damage. Her blood pressure remained elevated despite initial antihypertensive therapy adjustments, with readings consistently around 140/90 mmHg, indicating the need for further intervention to protect her renal function and reduce cardiovascular risk.

Newly obtained blood work indicated a further decline in her renal function. Her serum creatinine had risen to 1.7 mg/dL, and her eGFR had decreased to 50 mL/min/1.73m². Additionally, her BUN had increased to 35 mg/dL, reinforcing the progression of her kidney impairment. These findings were concerning, as they suggested a more rapid decline in renal function than previously anticipated. Her hemoglobin level had dropped slightly further to 10.0 g/dL, underscoring the need to address her anemia more aggressively, potentially necessitating the initiation of erythropoiesis-stimulating agents and iron supplementation.

Given these results, a comprehensive review of her medication regimen was initiated, including the consideration of adding a second antihypertensive agent, such as an angiotensin receptor blocker, to better control her blood pressure and reduce proteinuria. Close monitoring for potential side effects and regular follow-up appointments were planned to assess the effectiveness of these interventions. The healthcare team also considered initiating discussions about potential future renal replacement therapies, including dialysis or transplantation, should her renal function continue to deteriorate. This diagnostic update provides a critical opportunity to refine her management plan and prevent further complications, setting the stage for evaluating her response to the intensified treatment strategy.

Section 3

Response to Interventions

Two weeks into the new management plan, the patient returned for a follow-up visit, presenting mixed results from the intensified treatment strategy. Her blood pressure had shown some improvement, now averaging 130/85 mmHg, following the addition of an angiotensin receptor blocker to her regimen. This reduction in blood pressure was a positive indicator as it suggested a potential decrease in her risk for further renal damage and cardiovascular complications. However, the patient reported experiencing occasional dizziness and fatigue, which raised concerns about the possibility of hypotension or electrolyte imbalances as side effects of the new medication regimen. Further evaluation revealed her serum potassium level had risen to 5.5 mmol/L, indicating hyperkalemia, a known risk associated with angiotensin receptor blockers, necessitating a careful balance between managing her blood pressure and preventing hyperkalemia.

Despite improvements in blood pressure management, her kidney function continued to decline. Her serum creatinine had increased slightly to 1.9 mg/dL, and her eGFR had dropped to 48 mL/min/1.73m², signaling ongoing renal impairment. Additionally, her proteinuria remained elevated with a protein-to-creatinine ratio of 4.2 mg/mg, suggesting persistent glomerular damage. The anemia management strategy showed promising results, with her hemoglobin level stabilizing at 10.5 g/dL following the initiation of erythropoiesis-stimulating agents and oral iron supplementation. This stabilization was encouraging but required ongoing monitoring to ensure continued efficacy and to adjust doses as needed.

These mixed outcomes prompted the healthcare team to re-evaluate the patient’s treatment plan. A multidisciplinary approach was emphasized, involving nephrologists, dietitians, and pharmacists, to optimize her care. Adjustments to her diet were recommended to manage her potassium levels and protein intake, aiming to minimize further kidney stress. Regular monitoring of her laboratory values and vital signs was instituted to promptly identify and address any emerging complications. Discussions about potential renal replacement therapies gained urgency, though the focus remained on delaying the need for such interventions through meticulous management of her current condition. This phase highlighted the importance of ongoing assessment and adaptability in her care strategy.

Section 4

Two weeks later, during another follow-up visit, the healthcare team noted a change in the patient's status that warranted immediate attention. The patient presented with increased fatigue, swelling in her lower extremities, and a noticeable decrease in urine output over the past few days. Her blood pressure had increased again, now registering at 145/92 mmHg, despite the ongoing medication regimen. These symptoms raised concerns about worsening kidney function and fluid retention, signaling a potential progression of her renal disease. A physical examination revealed pitting edema in both ankles and mild periorbital edema, suggestive of fluid overload.

New diagnostic results added clarity to the picture. Her serum creatinine had risen to 2.3 mg/dL, and her eGFR had further decreased to 42 mL/min/1.73m², indicating continued renal function decline. Additionally, her proteinuria had worsened, with a protein-to-creatinine ratio now at 5.0 mg/mg. Electrolyte analysis showed her potassium level had remained high at 5.4 mmol/L, despite dietary interventions, raising the risk of cardiac complications. Her hemoglobin level remained stable at 10.3 g/dL, but there was growing concern about her overall fluid and electrolyte balance. These findings indicated that her current management plan might need further adjustment to address her evolving condition.

In response to these developments, the healthcare team considered several adjustments to her management plan. The diuretic therapy was intensified to help manage her edema and blood pressure, while close monitoring of her electrolyte levels was prioritized to prevent dangerous imbalances. The possibility of initiating a low-dose loop diuretic was discussed to enhance renal excretion of potassium, given the ongoing hyperkalemia. A repeat assessment of her dietary plan was undertaken, focusing on further reducing sodium and potassium intake while ensuring adequate nutrition. This phase of her care underscored the dynamic nature of managing pediatric kidney disease and highlighted the critical need for continuous monitoring and the ability to adapt interventions promptly in response to new complications.

Section 5

As the healthcare team implemented the updated management plan, they closely monitored the patient's response to the intensified diuretic therapy and dietary adjustments. Over the following week, the patient showed some improvement in her edema, with a noticeable reduction in swelling of the lower extremities and periorbital areas. However, her overall energy levels remained low, and her urine output had only marginally increased. A repeat set of laboratory tests was conducted to evaluate the effectiveness of the current interventions.

The new diagnostic results revealed that her serum creatinine had decreased slightly to 2.1 mg/dL, suggesting a minor improvement in kidney function. However, her eGFR remained relatively unchanged at 44 mL/min/1.73m², indicating that her renal impairment was still significant. The protein-to-creatinine ratio had improved marginally to 4.7 mg/mg, reflecting a slight reduction in proteinuria. Despite these positive trends, her potassium level was still elevated at 5.2 mmol/L, necessitating continued vigilance to prevent cardiac risks.

Given these findings, the healthcare team recognized that while some progress had been made, the patient's condition required further adjustments to optimize her management. The decision was made to introduce a low-dose loop diuretic to better control her hyperkalemia while continuing to monitor her fluid status and electrolyte levels closely. Additionally, the patient's dietary plan was further refined to limit potassium intake more stringently, and regular follow-ups were scheduled to reassess her kidney function and overall health. This approach emphasized the importance of individualized care and the need for ongoing adaptation of treatment strategies in response to the intricate challenges of pediatric kidney disease.