Skin conditions - Nursing Case Study
Pathophysiology
• Primary mechanism: Inflammation - Skin conditions often originate from inflammatory responses, where immune cells release cytokines leading to redness, swelling, and pain. This is seen in conditions like eczema and psoriasis, where an overactive immune response targets skin cells.
• Secondary mechanism: Barrier dysfunction - The skin's protective barrier can be compromised, allowing irritants, allergens, and pathogens to penetrate more easily. This is particularly relevant in atopic dermatitis, where genetic factors lead to a defective barrier, exacerbating inflammation and increasing infection risk.
• Key complication: Chronicity and infection - Persistent inflammation and barrier dysfunction can result in chronic skin conditions and increased susceptibility to bacterial infections, further complicating management and treatment strategies.
Patient Profile
Demographics:
45-year-old female, office worker
History:
• Key past medical history: Eczema, seasonal allergies
• Current medications: Hydrocortisone cream, Loratadine
• Allergies: Penicillin
Current Presentation:
• Chief complaint: Worsening rash with itching and discomfort
• Key symptoms: Red, inflamed skin with occasional blistering, dry patches, and peeling; mild swelling in the affected area
• Vital signs: Temperature 99.1°F, Blood Pressure 145/90 mmHg, Heart Rate 92 bpm, Respiratory Rate 18 breaths per minute
Section 1
Initial Assessment Findings:
Upon further examination, the affected areas reveal extensive erythema and scaling, primarily on the forearms and neck, with some areas exhibiting lichenification, indicating chronicity. The patient reports the itching has intensified over the past two weeks, interfering with her sleep and daily activities. Notably, there are small vesicles on the forearms, some of which have ruptured, leaving crusted lesions. The surrounding skin is warm to the touch, suggesting acute inflammation. The patient also notes increased sensitivity to soaps and fragrances, which she previously tolerated well.
Vital signs during this assessment show a slight increase in temperature to 99.5°F, with blood pressure remaining elevated at 147/92 mmHg and heart rate at 94 bpm. These findings indicate a possible low-grade fever and consistent hypertension, potentially exacerbated by discomfort and lack of sleep. The respiratory rate remains stable at 18 breaths per minute, with no signs of respiratory distress. Palpation of lymph nodes in the axillary and cervical regions shows mild tenderness and slight enlargement, raising suspicion for secondary bacterial infection.
Given these findings, the immediate clinical priority is to address the potential infection while managing the inflammation and pruritus. The patient is educated on avoiding known irritants and instructed to apply a topical antibiotic to the affected areas with crusting. Additionally, an oral antihistamine is considered to alleviate itching and improve sleep quality. A follow-up appointment is scheduled to reassess the condition and adjust treatment based on the patient's response and any new developments. The possibility of systemic involvement or the need for more aggressive treatment, such as systemic antibiotics or immunomodulators, will be considered depending on the progression of symptoms.
Section 2
Two weeks following the initial assessment, the patient returns for a follow-up appointment. She reports some relief from the pruritus after using the prescribed oral antihistamine, which has also improved her sleep quality. However, she continues to experience significant scaling and erythema, and new developments have raised additional concerns. The patient now exhibits bilateral lower extremity edema, and she reports a tingling sensation in her fingers and toes. She also mentions feeling more fatigued than usual, which she attributes to her ongoing skin issues.
Upon examination, the nurse notes that the erythema and scaling have spread to the patient's torso and legs, with more pronounced lichenification in these areas. The previously noted vesicles on the forearms have increased in number, some now appearing on the legs as well. The crusted lesions from the ruptured vesicles have become more extensive, and there is a noticeable purulent discharge, indicating a possible secondary bacterial infection. The patient's temperature is now 100.2°F, her blood pressure has increased to 152/95 mmHg, and her heart rate is 100 bpm. These changes suggest an exacerbation of inflammation and possible systemic involvement. Laboratory results reveal leukocytosis with a white blood cell count of 13,000/mm³ and an elevated erythrocyte sedimentation rate (ESR) of 40 mm/hr, further supporting the presence of a systemic inflammatory response.
Given these developments, the clinical team considers escalating the treatment plan to address the potential systemic involvement and more aggressively manage the infection. The patient is started on a course of oral antibiotics to target the suspected bacterial component. Further, a dermatology referral is made to evaluate the need for immunomodulatory therapy, considering the chronic and widespread nature of the condition. The clinical reasoning process now involves closely monitoring the patient's response to the new interventions, assessing for signs of systemic improvement, or further complications such as electrolyte imbalances from the edema. The team plans for a tighter follow-up schedule to adjust treatment promptly based on the patient's evolving clinical status.
Section 3
As the patient continues with the adjusted treatment plan, including the newly prescribed oral antibiotics, she returns for a follow-up visit one week later. During this appointment, the nurse conducts a comprehensive assessment to evaluate the patient's response to the interventions. The patient reports a partial reduction in the erythema and scaling, particularly on her torso and arms. However, she notes that the edema in her lower extremities persists, and the tingling sensation in her fingers and toes remains unchanged. The purulent discharge from the crusted lesions has decreased, suggesting some improvement in the bacterial infection, yet several new vesicles have appeared on her back, raising concerns about the ongoing inflammatory process.
The nurse records the patient's vital signs and notes a slight improvement: the temperature has decreased to 99.5°F, and the heart rate is now 92 bpm. However, the blood pressure remains elevated at 150/93 mmHg. A repeat set of laboratory tests shows a marginal decrease in the white blood cell count to 12,500/mm³ and a slight reduction in the ESR to 38 mm/hr, indicating a slow but positive response to the systemic antibiotic therapy. Despite these improvements, the persistent edema and neurological symptoms suggest that the systemic involvement might be more complex than initially anticipated.
The clinical team decides to order additional diagnostic tests, including an electrolyte panel and a nerve conduction study, to explore potential underlying causes of the edema and paresthesia. They also opt to expedite the dermatology referral to explore the initiation of immunomodulatory therapy more urgently, considering the chronic, extensive nature of the skin condition and the systemic symptoms. These steps are crucial to refine the treatment plan further and address the multifaceted aspects of the patient’s condition, ensuring a comprehensive approach to her care. The team schedules another follow-up appointment in one week to closely monitor the patient's progress and adjust interventions as necessary.
Section 4
During the subsequent follow-up visit, the nurse notes several key changes in the patient's condition, reflecting new diagnostic results and a change in her status. The electrolyte panel reveals a mild hyponatremia with a sodium level of 132 mEq/L, which may be contributing to the patient's persistent edema and neurological symptoms. The nerve conduction study indicates a mild peripheral neuropathy, raising concerns about a possible autoimmune involvement given the chronicity and extent of the skin condition. These findings suggest an underlying systemic issue that might be affecting both the skin and nervous system, warranting a more aggressive diagnostic and therapeutic approach.
Clinically, the patient reports that while the previous interventions have led to some improvement in her erythema and infection control, her overall discomfort has increased due to the persistent tingling and new vesicles on her back. The physical exam corroborates these complaints, showing persistent lower extremity edema and several new tense vesicles on her back, which are tender to touch. The patient's vital signs reveal no significant changes from the last visit, except for a slight decrease in heart rate to 88 bpm, but her blood pressure remains elevated at 148/90 mmHg, indicating ongoing systemic stress.
In response to these findings, the clinical team decides to initiate a trial of immunomodulatory therapy sooner than planned, to address the potential autoimmune component and mitigate further systemic complications. Additionally, the patient is advised to increase her fluid intake moderately to address the hyponatremia and is referred to a neurologist to explore further management options for the neuropathy. These interventions aim to stabilize her condition while providing symptomatic relief, with a plan for a comprehensive re-evaluation in another week to assess the effectiveness of the adjusted treatment strategy and make necessary modifications.
Section 5
One week later, the patient returns for her follow-up appointment. Upon initial assessment, the nurse observes that the patient appears fatigued and reports increased difficulty sleeping due to persistent discomfort and itching. Her vital signs show a slight improvement in blood pressure, now at 142/88 mmHg, possibly reflecting an initial response to the immunomodulatory therapy. However, her heart rate has decreased further to 82 bpm, potentially indicating a need to adjust her medication regimen. The patient continues to experience lower extremity edema, and her weight has increased by 1.5 kg since the last visit, suggesting that fluid retention remains a concern.
The new diagnostic results reveal a worsening of her hyponatremia, with her sodium level now at 130 mEq/L. This electrolyte imbalance could be contributing to her ongoing fatigue and new reports of mild confusion, raising the suspicion of a more complex underlying endocrine or renal issue. The neurologist's report confirms the presence of peripheral neuropathy, with a recommendation to start gabapentin for symptomatic relief, while further autoimmune markers are being evaluated to clarify the etiology of her condition.
Clinically, the patient's skin condition shows mixed results: while the previously noted erythema has diminished, the vesicles on her back have increased in number and are now accompanied by a few pustular lesions, suggesting a possible secondary infection or worsening of her autoimmune skin condition. The care team decides to continue with the immunomodulatory therapy but adds a broad-spectrum antibiotic to address the potential infection, along with a diuretic to manage the edema. With these adjustments, the patient is scheduled for another follow-up in a week to closely monitor her response and make any necessary changes to the treatment plan. This situation highlights the need for ongoing clinical reasoning to integrate her complex symptoms and laboratory findings into a cohesive management strategy.