Geriatric syndrome - Nursing Case Study

Pathophysiology

• Primary mechanism: Frailty and decreased physiological reserve - Aging leads to multi-system decline, reducing the body's ability to maintain homeostasis and respond to stressors, making older adults more susceptible to disease and functional decline.

• Secondary mechanism: Polypharmacy and medication interactions - Older adults often take multiple medications, increasing the risk of adverse effects and drug interactions, which can exacerbate existing conditions and contribute to cognitive and physical impairments.

• Key complication: Increased vulnerability to acute stressors - The interplay of frailty and polypharmacy can lead to a spiral of declining health, where minor illnesses or stressors can result in significant functional deterioration, hospitalizations, or increased mortality.

Patient Profile

Demographics:

78-year-old female, retired schoolteacher

History:

• Key past medical history: Hypertension, osteoarthritis, mild cognitive impairment

• Current medications: Lisinopril 10 mg daily, Acetaminophen 500 mg as needed, Donepezil 5 mg daily

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Increasing difficulty with mobility and frequent falls

• Key symptoms: Generalized weakness, joint stiffness, occasional confusion, urinary incontinence

• Vital signs: Blood pressure 150/92 mmHg, heart rate 88 bpm, respiratory rate 22 breaths per minute, temperature 98.6°F, oxygen saturation 94% on room air

Section 1

New Diagnostic Results:

Upon further evaluation of the patient's symptoms and history, a comprehensive geriatric assessment was conducted, including laboratory tests and imaging studies. Blood work revealed a mild anemia with hemoglobin levels at 10.5 g/dL, slightly elevated creatinine at 1.3 mg/dL, and a vitamin D deficiency with serum levels at 18 ng/mL. These findings suggest potential nutritional deficiencies and renal function decline, which may contribute to her frailty and increased fall risk. A urinalysis was performed due to the urinary incontinence, showing signs of a possible urinary tract infection, with leukocyte esterase and nitrites present, prompting a urine culture for further evaluation.

Imaging via X-ray of the hip and knee joints showed moderate degenerative changes consistent with osteoarthritis, likely contributing to her joint stiffness and mobility issues. Furthermore, a CT scan of the brain was performed due to her occasional confusion, revealing no acute intracranial abnormalities but showing evidence of mild cerebral atrophy, correlating with her known mild cognitive impairment.

These diagnostic findings highlight the multifactorial nature of her condition, where anemia, vitamin deficiencies, potential infection, and chronic joint deterioration interplay to exacerbate her frailty and cognitive challenges. The results necessitate a multidisciplinary approach to address her nutritional status, possible infection, and fall prevention strategies while closely monitoring her cognitive and renal function. This will require adjustments in her medication regimen and coordination with physical therapy to enhance her mobility and reduce her fall risk, emphasizing the need for a tailored, holistic plan to stabilize her condition and prevent further complications.

Section 2

Change in Patient Status:

Several weeks into the implementation of the multidisciplinary care plan, the patient presented with an unexpected change in status during a follow-up visit. She reported increased fatigue and a noticeable decline in her ability to perform daily activities, which raised concerns about her overall functional status. On examination, her vital signs were stable with a blood pressure of 130/80 mmHg, heart rate of 78 bpm, respiratory rate of 16 breaths per minute, and an oxygen saturation of 96% on room air. However, she appeared pale and had a slightly elevated temperature of 100.2°F, suggesting a possible underlying infection.

A repeat set of laboratory tests was ordered to further investigate these changes. The results indicated a drop in hemoglobin levels to 9.8 g/dL, exacerbating her anemia and potentially contributing to her fatigue. The urine culture results came back positive for Escherichia coli, confirming a urinary tract infection that may explain her low-grade fever and increased confusion. Additionally, her serum creatinine had risen to 1.5 mg/dL, pointing to a further decline in renal function, possibly impacted by the ongoing infection and dehydration.

These findings necessitate a reassessment of her current management plan. The decline in her hemoglobin levels and renal function, alongside the confirmed urinary tract infection, underscore the need for immediate intervention. The care team must initiate appropriate antibiotic therapy to address the infection, consider adjustments to her anemia management strategy, and ensure adequate hydration to support her renal function. This change in patient status provides an opportunity to re-evaluate her current medications and dietary plans, while emphasizing the importance of monitoring her cognitive and physical health closely to prevent further complications.

Section 3

Following the initiation of antibiotic therapy for her urinary tract infection and adjustments to her anemia management, the patient initially showed signs of improvement. Her fever subsided, and there was a slight boost in her energy levels, allowing her to engage more actively in her daily routines. However, within a week, she began to experience new symptoms, including mild dyspnea and persistent swelling in her lower extremities. Her family reported that she seemed increasingly disoriented and was struggling to recall recent events, raising concerns about potential worsening of her cognitive function.

During a subsequent evaluation, her vital signs remained within normal limits, yet her blood pressure was slightly elevated at 140/85 mmHg. Her heart rate was consistent at 80 bpm, and her respiratory rate was at 18 breaths per minute with an oxygen saturation of 95% on room air. A physical examination revealed bilateral pitting edema in her ankles and feet, suggesting possible fluid retention. Laboratory tests showed a further decrease in hemoglobin to 9.5 g/dL and a rise in serum creatinine to 1.8 mg/dL, indicating progressive renal impairment. Additionally, her brain natriuretic peptide (BNP) levels were elevated, suggesting the possibility of heart failure exacerbation as a contributing factor to her symptoms.

These developments necessitate a comprehensive review of her current treatment regimen with a focus on managing fluid overload and addressing her cognitive decline. The care team must consider diuretic therapy to alleviate the edema and monitor her renal function closely to prevent further deterioration. Her cognitive symptoms warrant a detailed evaluation to rule out other potential causes, including medication side effects and electrolyte imbalances. This phase of her care underscores the importance of an integrated approach to managing her complex condition, balancing the need to address her immediate symptoms while also preventing future complications.

Section 4

Following the decision to initiate diuretic therapy, the patient was prescribed furosemide to address her fluid overload and manage the bilateral pitting edema. In the days that followed, there was a noticeable reduction in the swelling of her lower extremities, and her breathing became slightly easier, indicating a positive response to the intervention. Despite these improvements, the patient's cognitive symptoms persisted, prompting further investigation into potential underlying causes.

A more detailed cognitive assessment and review of her medication regimen were conducted to explore possible contributors to her disorientation and memory difficulties. The evaluation revealed that the patient had been experiencing mild hyponatremia, with her sodium levels dropping to 130 mmol/L. This electrolyte imbalance, likely exacerbated by the diuretic therapy, was identified as a potential factor in her cognitive decline. Additionally, a thorough review of her medications suggested that polypharmacy might be playing a role, as she was taking multiple prescriptions that could impact cognitive function.

To address these findings, the care team adjusted her diuretic dosage and implemented a plan to gradually correct her sodium levels, ensuring careful monitoring to prevent rapid shifts that could cause further complications. Her medication regimen was also streamlined to minimize potential interactions and side effects. As these adjustments were made, the patient began to show subtle improvements in her cognitive awareness, though continued monitoring and supportive care were deemed necessary. This phase of her care highlighted the need for ongoing vigilance and adaptability in managing her complex geriatric syndrome, setting the stage for further exploration of her multifaceted health challenges.

Section 5

A week after the adjustments to her treatment plan, the patient experienced a change in her status that necessitated further evaluation. While her cognition showed slight improvement, the patient began to exhibit signs of orthostatic hypotension, characterized by dizziness and lightheadedness upon standing. Her blood pressure readings revealed a significant drop from 135/85 mmHg when seated to 105/70 mmHg upon standing. This sudden development raised concerns about the balance of her fluid status and the impact of ongoing diuretic therapy, especially in the context of her already complex medication regimen.

In conjunction with these symptoms, the patient also reported increased fatigue and muscle weakness, prompting the care team to conduct additional laboratory tests. The results indicated a more pronounced electrolyte imbalance, with potassium levels now reduced to 3.2 mmol/L, suggesting hypokalemia as a potential contributor to her new symptoms. The care team immediately recognized the need to adjust her diuretic therapy further and considered the addition of a potassium-sparing diuretic to help stabilize her electrolyte levels.

These developments underscored the complexity of managing geriatric syndromes, emphasizing the importance of vigilant monitoring and timely intervention. The patient’s care plan was updated to include more frequent blood pressure monitoring, a revised electrolyte replacement protocol, and a reassessment of her overall medication strategy to mitigate the risk of further complications. This phase of her journey highlighted the intricate interplay between therapeutic interventions and the patient's evolving clinical status, setting the stage for continuous reevaluation and adaptation of her treatment plan.