Bipolar - Nursing Case Study

Pathophysiology

• Primary mechanism: Neurotransmitter Imbalance - Bipolar disorder involves dysregulation in neurotransmitters, particularly serotonin, dopamine, and norepinephrine. These chemical messengers play crucial roles in mood regulation, and their imbalance can lead to the mood swings characteristic of the disorder.

• Secondary mechanism: Neuroplasticity Alterations - Patients with bipolar disorder often exhibit changes in brain structure and function over time. This includes alterations in neural circuits related to emotion regulation, which can affect the brain's ability to adapt and process emotional stimuli effectively.

• Key complication: Emotional Dysregulation - The combined effect of neurotransmitter imbalance and altered neuroplasticity can lead to severe mood episodes, ranging from manic highs to depressive lows, complicating daily functioning and increasing the risk of comorbidities such as anxiety disorders and substance abuse.

Patient Profile

Demographics:

34-year-old female, graphic designer

History:

• Key past medical history: Diagnosed with Bipolar II disorder 5 years ago, history of anxiety

• Current medications: Lamotrigine 100 mg daily, Sertraline 50 mg daily

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Increased mood swings and anxiety

• Key symptoms: Periods of hypomania, depressive episodes, insomnia, irritability, frequent headaches

• Vital signs: Blood pressure 150/95 mmHg, heart rate 110 bpm, respiratory rate 20 breaths per minute, temperature 98.6°F

Section 1

Following the initial presentation, the healthcare team proceeded with a comprehensive assessment to better understand the patient’s current condition. During the mental status examination, the patient exhibited rapid speech and tangential thought processes, consistent with hypomanic episodes. Despite her elevated mood, she reported experiencing pervasive feelings of hopelessness and guilt, indicative of underlying depressive symptoms. Physical examination revealed significant psychomotor agitation, and she expressed difficulty concentrating, impacting her work as a graphic designer. Additionally, the patient noted that her headaches had become more frequent and intense, which she rated as a 7 out of 10 on the pain scale.

Laboratory tests were ordered to rule out any physiological contributors to her symptoms. A complete blood count (CBC) and comprehensive metabolic panel (CMP) were within normal limits, suggesting no acute infections or metabolic imbalances. However, her serum thyroid-stimulating hormone (TSH) level was slightly elevated, raising concerns about possible thyroid dysfunction contributing to her mood instability. Furthermore, an electrocardiogram (ECG) was performed due to her elevated heart rate and blood pressure, both of which remained high despite resting conditions. The ECG indicated sinus tachycardia, but with no other significant abnormalities.

The patient’s clinical picture suggested that her current medication regimen might require adjustment. The persistence of mood swings and anxiety, along with the new finding of potential thyroid involvement, prompted the healthcare team to consider a more integrated approach. This could involve consulting with a psychiatrist to evaluate the efficacy of her current medications and possibly introducing a mood stabilizer or adjusting her existing dosages. Additionally, an endocrinology referral could be beneficial to assess and manage any thyroid-related issues, which may be exacerbating her psychiatric symptoms. The goal would be to stabilize her mood while addressing any underlying physiological factors, ultimately improving her quality of life and functionality.

Section 2

As the healthcare team proceeded with the integrated approach, the patient was referred to both psychiatry and endocrinology. The psychiatrist reviewed her medication regimen and decided to adjust the dosage of her current mood stabilizer while initiating a low-dose atypical antipsychotic to help manage her hypomanic symptoms. Simultaneously, the endocrinologist conducted a thorough evaluation and ordered additional thyroid function tests, which revealed a mild elevation in free T4 levels, confirming a diagnosis of subclinical hyperthyroidism. With this new information, the endocrinologist recommended starting the patient on a low-dose beta-blocker to address both her sinus tachycardia and the hyperthyroid symptoms contributing to her anxiety and mood fluctuations.

Over the next two weeks, the patient’s status showed some improvement; her mood swings became less frequent, and her anxiety levels decreased slightly. However, she began experiencing new complications, including increased fatigue and episodes of dizziness, particularly in the mornings. Her vital signs revealed persistent tachycardia with a heart rate of 110 beats per minute and elevated blood pressure of 145/90 mmHg, despite the beta-blocker therapy. Additionally, the patient reported that her headaches, though less frequent, were now accompanied by visual disturbances such as blurring and occasional flashing lights.

These new developments necessitated a deeper clinical reasoning approach. The healthcare team considered the possibility of the beta-blocker contributing to her fatigue and dizziness, warranting a reassessment of its dosage or a trial of an alternative medication. The visual disturbances raised concerns about potential medication side effects or an underlying neurological issue, prompting a referral to a neurologist for further evaluation. The team remained focused on balancing her psychiatric and physiological needs, aiming to refine her treatment plan to alleviate her symptoms without introducing additional complications. This would involve ongoing monitoring of her thyroid levels, cardiovascular status, and mood, with close collaboration between the psychiatric, endocrinology, and neurology teams.

Section 3

One week later, the patient underwent a comprehensive neurological assessment to explore the cause of her visual disturbances and dizziness. The neurologist conducted a detailed history and physical examination, noting that the patient experienced visual symptoms predominantly in the morning and that these episodes were sometimes accompanied by mild headaches. An MRI of the brain was ordered and revealed no acute intracranial abnormalities, but there was evidence of mild cerebral white matter changes, which could be consistent with chronic migraine or vascular changes. Given her persistent tachycardia and hypertension, the neurologist recommended a closer look at her cardiovascular health and suggested a tilt-table test to assess for potential autonomic dysfunction as a contributing factor to her dizziness and fatigue.

Meanwhile, the patient's thyroid function tests were repeated, showing a slight decrease in free T4 levels, though still above normal, and a newly elevated TSH, suggesting the potential beginning of a transition towards hypothyroidism. This fluctuation in thyroid status could be contributing to her persistent fatigue and mood symptoms. The endocrinologist recommended continuing the beta-blocker but lowering the dose to mitigate fatigue and dizziness, while also considering the introduction of a low-dose thyroid replacement therapy to stabilize her thyroid function and potentially improve her energy levels.

The healthcare team continued to integrate the input from all specialists, focusing on fine-tuning the patient's medication regimen to address her multifaceted symptoms. The interdisciplinary team planned to re-evaluate her treatment response in two weeks, paying close attention to her cardiovascular status, mood stability, and any further neurological symptoms. This approach required careful coordination and communication among the psychiatric, endocrinology, and neurology teams to ensure a holistic treatment plan that prioritized both her mental and physical health needs.

Section 4

Two weeks later, during a follow-up appointment, the patient presented with new complaints of increased fatigue, muscle weakness, and occasional palpitations. The interdisciplinary team noted that while her mood swings had slightly stabilized with the adjusted beta-blocker and initiation of low-dose thyroid replacement therapy, her physical symptoms were becoming more pronounced. Vital signs revealed persistent tachycardia with a heart rate of 102 beats per minute and mildly elevated blood pressure at 148/92 mmHg. The patient also reported difficulty concentrating, which was affecting her ability to perform daily activities and work-related tasks.

Blood tests showed a further elevation in TSH to 6.8 mIU/L, while free T4 levels had decreased slightly, now just within the low normal range. These results suggested that her hypothyroidism might be progressing despite the initial thyroid hormone supplementation. Additionally, serum electrolytes indicated a mild hyponatremia with sodium levels at 134 mmol/L, which could be contributing to her fatigue and cognitive difficulties. Given these findings, the healthcare team considered the possibility of an interaction between her current medications or an underlying condition affecting her electrolyte balance.

In response to these developments, the team decided to adjust her thyroid medication dosage to better address the hypothyroid symptoms and recommended a closer monitoring of her serum electrolytes. The endocrinologist also proposed a cardiac evaluation to further investigate her persistent tachycardia and potential autonomic dysfunction, which could be complicating her hypertension and contributing to her overall symptomatology. The team emphasized the importance of maintaining open communication with the patient regarding her treatment plan and encouraged her to report any new or worsening symptoms promptly, paving the way for the next steps in managing her complex health needs.

Section 5

Several days after the adjustments in her treatment plan, the patient returned to the clinic with new concerns. She reported experiencing increased anxiety and a sensation of shortness of breath, particularly at night. Despite the recent increase in her thyroid medication, her fatigue and muscle weakness persisted, and she now noticed some swelling in her lower extremities. During the physical examination, the clinician noted mild bilateral pitting edema in her ankles and observed that her heart rate remained elevated at 110 beats per minute, with a blood pressure of 150/95 mmHg. The patient expressed frustration over her inability to concentrate at work, which was causing significant stress and impacting her daily life.

In light of these symptoms, further diagnostic testing was conducted. Repeat blood work showed a slight improvement in her TSH levels, now at 5.5 mIU/L, but her free T4 remained at the low end of normal, suggesting that her thyroid function was still not optimally managed. Electrolyte analysis revealed that her sodium levels had dropped further to 132 mmol/L, intensifying concerns about her electrolyte imbalance. Additionally, a 24-hour Holter monitor indicated frequent premature atrial contractions, possibly explaining her palpitations and anxiety. These findings pointed towards a possible cardiac component to her symptoms, alongside the unresolved endocrine issues.

The healthcare team recognized the need for a more nuanced approach to her treatment. They planned to further adjust her thyroid medication to target a more effective balance, while also considering the use of a diuretic to manage her edema and electrolyte imbalance. A referral to a cardiologist was made to explore potential underlying cardiac conditions contributing to her persistent tachycardia and palpitations. This multidisciplinary approach aimed to address the interconnected nature of her symptoms and improve her overall quality of life. The patient was advised to maintain close communication with her healthcare providers and to monitor her symptoms carefully, as her treatment plan continued to evolve.