urinary retention related to antipsychotics - Nursing Case Study

Pathophysiology

• Primary mechanism: Antipsychotics often possess anticholinergic properties, which inhibit the action of acetylcholine on muscarinic receptors in the bladder, leading to detrusor muscle relaxation and impaired bladder contraction, resulting in urinary retention.

• Secondary mechanism: Some antipsychotics may also antagonize alpha-adrenergic receptors, particularly in the bladder neck and urethra, causing increased smooth muscle tone and further obstruction of urine flow.

• Key complication: Persistent urinary retention can lead to bladder overdistension, increasing the risk of urinary tract infections, kidney damage, and potentially requiring catheterization for relief.

Patient Profile

Demographics:

45-year-old male, software engineer

History:

• Key past medical history: Schizophrenia, hypertension

• Current medications: Olanzapine, Lisinopril

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Difficulty urinating and lower abdominal discomfort

• Key symptoms: Incomplete bladder emptying, increased urinary frequency, mild confusion

• Vital signs: Blood pressure 150/95 mmHg, heart rate 95 bpm, temperature 98.6°F, respiratory rate 18 breaths per minute

Section 1

Initial Assessment Findings:

Upon further assessment, the nurse notes that the patient exhibits signs of mild suprapubic tenderness upon palpation, indicating possible bladder overdistension. The patient reports feeling the urge to urinate frequently but is unable to produce more than a small amount of urine each time, suggesting incomplete bladder emptying. A bladder scan is performed, revealing a post-void residual volume of 450 mL, confirming significant urinary retention. The patient's mild confusion persists, which may be attributed to discomfort or early signs of a urinary tract infection.

Vital signs are reassessed: the patient's blood pressure remains elevated at 155/98 mmHg, heart rate has increased to 100 bpm, and respiratory rate is steady at 18 breaths per minute, with no change in temperature. Given these findings, the healthcare team considers the potential need for catheterization to relieve the bladder and prevent further complications. The patient's mental status and potential risk for a urinary tract infection are also monitored closely, emphasizing the need for a urine culture to rule out infection as a contributing factor to his confusion.

These assessment findings create a clinical scenario where the nurse must prioritize interventions that address the urinary retention while considering the patient's ongoing risk for infection and renal complications. The team plans to discuss medication adjustments with the prescribing psychiatrist to mitigate the anticholinergic effects of olanzapine, balancing the management of his psychiatric condition with the need to resolve urinary complications. This approach will guide the next steps in the patient's care, focusing on alleviating symptoms and preventing further deterioration.

Section 2

New Diagnostic Results:

As the team proceeds with the care plan, a urine culture is obtained to identify any potential pathogens contributing to the patient's confusion and urinary symptoms. The results come back positive for Escherichia coli, suggesting a urinary tract infection (UTI) secondary to the urinary retention. This finding aligns with the mild confusion and suprapubic discomfort previously observed, reinforcing the need for prompt intervention to address both the infection and underlying urinary retention. The lab results show elevated white blood cell count at 13,000/µL, supporting the diagnosis of an infection. Additionally, the patient’s creatinine level is slightly elevated at 1.4 mg/dL, indicating the need for careful monitoring of renal function.

In response to these new diagnostic findings, the healthcare team initiates a targeted antibiotic therapy to combat the UTI, while continuing to evaluate the need for catheterization to relieve the bladder distension. The prescribing psychiatrist is consulted to discuss possible adjustments to the patient’s antipsychotic regimen, with consideration given to switching to a medication with a lower anticholinergic burden or modifying the dosing schedule. The patient is educated about the importance of maintaining adequate hydration and promptly reporting any changes in symptoms, such as increased confusion or discomfort, which could signal further complications. With these interventions, the team aims to manage the infection effectively while mitigating the risks associated with prolonged urinary retention, setting the stage for possible improvement in the patient’s clinical status.

Section 3

Response to Interventions:

Following the initiation of targeted antibiotic therapy, the patient shows initial signs of improvement. Within 48 hours, the patient's temperature stabilizes at 98.6°F, and their white blood cell count decreases to 10,500/µL, indicating a positive response to the treatment of the urinary tract infection. The suprapubic discomfort begins to subside, and the patient is more alert, with a noticeable reduction in confusion. Despite these improvements, the patient continues to experience intermittent episodes of urinary urgency and hesitancy, suggesting that the underlying urinary retention remains a significant issue.

The healthcare team decides to implement a bladder scan to assess post-void residual volume, revealing 250 mL of urine remaining after voiding, indicating incomplete bladder emptying. Given the ongoing urinary retention, the decision is made to proceed with intermittent catheterization to relieve the bladder and prevent further complications. This intervention is carefully monitored, and the team educates the patient about recognizing symptoms of urinary retention and the importance of maintaining regular voiding schedules.

Simultaneously, the patient's psychiatric medication regimen is adjusted under the guidance of the psychiatrist. The antipsychotic is switched to a medication with a lower anticholinergic profile, aiming to reduce the adverse effects contributing to urinary retention. With these targeted interventions, the team is cautiously optimistic about the patient's trajectory towards recovery, while remaining vigilant for any signs of new complications, such as acute kidney injury, given the elevated creatinine levels. The patient is scheduled for follow-up renal function tests to ensure that kidney health is maintained as the treatment plan progresses.

Section 4

New Complications:

Despite the initial positive response to interventions, the patient starts experiencing new symptoms indicative of emerging complications. Over the next 24 hours, the patient reports increasing fatigue and a mild headache. On examination, the patient's blood pressure is noted to be 146/92 mmHg, which is elevated compared to previous readings. Additionally, there's a noticeable decrease in urine output, with amounts dropping to less than 400 mL in 24 hours, raising concerns about potential acute kidney injury. Laboratory tests are promptly ordered, revealing a creatinine level that has increased to 1.8 mg/dL from the previous 1.4 mg/dL, as well as elevated blood urea nitrogen (BUN) levels at 28 mg/dL.

These findings suggest a possible prerenal cause due to volume depletion, secondary to decreased fluid intake and urinary retention. The healthcare team acts quickly to address these issues, increasing the patient's fluid intake through careful oral hydration and continuing intermittent catheterization to ensure complete bladder emptying. A nephrology consult is requested to further evaluate and manage the potential renal complications. The team also re-evaluates the patient's antipsychotic medication plan, considering the necessity of further adjustments to minimize additional strain on renal function.

As the team monitors the patient's progress, they remain vigilant for any further decline in renal function or worsening of symptoms. Education is provided to the patient and family regarding the importance of adequate hydration and the recognition of symptoms that could indicate worsening kidney function. This phase of the patient's journey underscores the importance of comprehensive care and the need for continual reassessment to prevent and manage complications effectively.

Section 5

Over the next 48 hours, the patient's condition shows signs of gradual improvement, indicating a positive response to the adjustments in care. The increased oral hydration and continued intermittent catheterization have started to yield results, with urine output incrementally rising to 600 mL in 24 hours, suggesting partial resolution of the urinary retention and prerenal causes. The patient's creatinine level stabilizes, slightly decreasing to 1.6 mg/dL, and blood urea nitrogen (BUN) decreases to 24 mg/dL, indicating an improvement in kidney function. However, the patient's blood pressure remains slightly elevated at 142/90 mmHg, necessitating ongoing monitoring and possibly further intervention.

Despite these improvements, the patient begins to exhibit new symptoms, including mild confusion and a persistent headache, which raise concerns about additional complications. These neurological symptoms prompt the healthcare team to consider the possibility of antipsychotic-related side effects or other underlying causes such as electrolyte imbalances. A comprehensive metabolic panel is ordered, revealing a mild hyponatremia with a serum sodium level of 132 mEq/L, which could potentially explain the neurological manifestations. The team decides to cautiously adjust the patient's fluid intake to correct the electrolyte imbalance while continuing to monitor mental status closely.

In response to these developments, the interdisciplinary team, including nephrology and psychiatry, collaborates to reassess the patient's medication regimen. This includes evaluating the necessity and dosage of the current antipsychotic medication, balancing mental health stabilization with the minimization of adverse effects. Patient and family education is reinforced, emphasizing the signs of electrolyte imbalance and the importance of adherence to the revised care plan. This phase highlights the dynamic nature of patient care, where continuous evaluation and adaptation of treatment strategies are essential to address new complications effectively and promote overall recovery.