Asthma - Nursing Case Study

Pathophysiology

• Primary mechanism: Asthma is characterized by chronic inflammation of the airways, leading to hyperresponsiveness. This inflammation results in the release of inflammatory mediators like histamines and leukotrienes, causing bronchoconstriction and edema, which narrow the airways.

• Secondary mechanism: The hypersecretion of mucus further obstructs the airways. Goblet cell hyperplasia and increased mucus gland activity contribute to excessive and thick mucus production, exacerbating airflow limitation and causing difficulty in breathing.

• Key complication: If not managed, persistent airway inflammation and obstruction can lead to airway remodeling. This involves structural changes such as thickening of the airway wall and fibrosis, resulting in long-term loss of lung function and increased risk of severe asthma exacerbations.

Patient Profile

Demographics:

35-year-old female, school teacher

History:

• Key past medical history: Diagnosed with asthma 10 years ago, seasonal allergies, and a history of eczema

• Current medications: Albuterol inhaler as needed, Fluticasone nasal spray, Loratadine daily

• Allergies: Penicillin, dust mites

Current Presentation:

• Chief complaint: Increased shortness of breath and wheezing over the past week

• Key symptoms: Persistent cough, chest tightness, fatigue, and difficulty performing daily activities

• Vital signs: Temperature 99.2°F, Heart rate 110 bpm, Respiratory rate 24 breaths per minute, Blood pressure 140/90 mmHg, SpO2 92% on room air

Section 1

New Diagnostic Results:

Following the initial assessment, the healthcare team decided to obtain a chest X-ray and perform pulmonary function tests to gather more information about the patient's current respiratory status. The chest X-ray revealed mild hyperinflation of the lungs, a common finding in patients with asthma, but no signs of pneumonia or other acute processes. The pulmonary function tests showed a decrease in FEV1 (Forced Expiratory Volume in one second) to 65% of the predicted value, indicating a moderate obstruction. This finding is consistent with the patient's reported symptoms of increased shortness of breath and wheezing.

Additionally, a complete blood count (CBC) was performed, revealing an elevated eosinophil count of 8%, suggesting an exacerbation of the patient's allergic asthma component. An elevated serum IgE level was also noted, further supporting the presence of an allergic response. Given the patient's history of seasonal allergies and recent exposure to known allergens, it is likely that the current asthma exacerbation is being driven by environmental triggers, potentially complicated by inadequate baseline control of asthma symptoms.

The results prompted a review of the patient's current management plan. It was determined that the patient's reliance on as-needed albuterol inhaler might not be sufficient to control the underlying inflammation. Consequently, a step-up in therapy was considered, including the initiation of a low-dose inhaled corticosteroid and long-acting beta-agonist combination to better manage the chronic inflammation and prevent further exacerbations. This adjustment aims to address both the immediate symptoms and the underlying pathophysiology to prevent future complications, such as airway remodeling and persistent airflow limitation.

Section 2

Change in Patient Status:

Following the adjustment in the patient's asthma management plan, including the introduction of a low-dose inhaled corticosteroid and long-acting beta-agonist, the patient initially reported slight improvement in symptoms, particularly during the day. However, over the next 48 hours, the patient began experiencing increased nocturnal symptoms, with frequent awakenings due to coughing and shortness of breath. The patient also reported feeling more fatigued and noticed a decline in exercise tolerance. This change in status prompted a re-evaluation of the patient's condition.

Upon re-assessment, vital signs revealed a mild tachycardia with a heart rate of 104 beats per minute and an oxygen saturation of 92% on room air, slightly lower than previous measurements. Auscultation of the lungs indicated persistent wheezing with diminished breath sounds in the lower lobes, bilaterally. There was no significant use of accessory muscles at this time, but the patient appeared mildly dyspneic at rest. Given these findings, the healthcare team suspected that the current treatment plan might not be adequately controlling the underlying inflammation and that the patient could be developing a more severe exacerbation or an additional complication, such as a viral respiratory infection.

In response to the patient's deteriorating condition, further diagnostic tests were ordered, including a repeat pulmonary function test and a sputum culture to rule out infection. Additionally, a discussion was initiated regarding the potential need for systemic corticosteroids to provide more aggressive management of the inflammatory response. The team also considered a referral to an allergist for possible allergen immunotherapy, given the significant allergic component of the patient's asthma. These steps aimed to stabilize the patient's condition and prevent further decline while addressing both the immediate symptoms and the underlying causes.

Section 3

New Diagnostic Results

The results from the repeat pulmonary function test indicated a significant decline in the patient's FEV1, which had dropped to 68% of the predicted value, down from 78% previously. This decrease suggested a worsening obstruction of the airways, consistent with an exacerbation of asthma. The patient's peak expiratory flow rate (PEFR) also showed a similar downward trend, further confirming the reduced airflow. The sputum culture revealed the presence of rhinovirus, indicating that a viral respiratory infection might be contributing to the exacerbation of symptoms. These findings highlighted that the patient's current management plan was insufficient in addressing the acute inflammation and bronchoconstriction exacerbated by the viral infection.

In light of these new diagnostic results, the healthcare team decided to initiate a course of systemic corticosteroids to rapidly reduce airway inflammation. The patient was started on oral prednisone, with instructions for a tapering dose over the following week. Additionally, the team increased the frequency of the patient's rescue inhaler use and advised the continuation of the inhaled corticosteroid and long-acting beta-agonist regimen. The team also emphasized the importance of hydration and rest to support recovery from the viral infection. A follow-up appointment was scheduled in one week to reassess the patient's lung function and overall condition.

This approach aimed to address both the immediate inflammatory response and the viral component, providing a comprehensive strategy to stabilize the patient's condition. The plan also included education on identifying early signs of worsening asthma and instructions on when to seek immediate medical attention, especially if symptoms did not improve or deteriorated further. This step was crucial to prevent further complications and ensure the patient could return to optimal health.

Section 4

Three days into the patient's new treatment regimen, her condition showed mixed responses. Upon initial assessment, the patient reported a slight improvement in her ability to breathe, but she continued to experience significant wheezing and coughing, particularly at night. Her vital signs revealed a mild fever of 37.9°C (100.2°F), a heart rate of 98 beats per minute, and a respiratory rate of 22 breaths per minute, with oxygen saturation fluctuating between 92% and 94% on room air. Auscultation of the lungs revealed diffuse bilateral wheezes and occasional crackles, suggesting ongoing bronchoconstriction and possible mucus accumulation despite the current interventions.

In addition to the respiratory symptoms, the patient began to experience new complications, including increased fatigue and muscle weakness, likely related to the systemic corticosteroid therapy. Her blood glucose levels were slightly elevated, measuring around 150 mg/dL, indicating a possible side effect of prednisone. This necessitated careful monitoring of her glucose levels and potential adjustments to her diet or medication to prevent further complications. The patient's peak expiratory flow rate remained below baseline, with readings consistently around 250 L/min, reinforcing the need for continued and enhanced therapeutic strategies.

The healthcare team recognized the need for further intervention to address these challenges. They discussed the possibility of adding a short course of a nebulized bronchodilator to provide more immediate relief from bronchoconstriction. Additionally, they considered stepping up her inhaled corticosteroid dosage temporarily to combat persistent inflammation. The team also planned to involve a dietitian to address potential dietary modifications to manage her blood glucose levels. These steps were intended to optimize the patient's recovery trajectory and prevent the development of more severe complications. A follow-up appointment was scheduled in four days to closely monitor progress and adjust treatment as necessary.

Section 5

Four days after implementing the new interventions, the patient returned for her follow-up appointment. During the initial assessment, it was noted that her respiratory symptoms had shown some improvement. The patient reported a decrease in nocturnal wheezing and coughing after the addition of the nebulized bronchodilator. Her peak expiratory flow rate had improved slightly, now averaging around 280 L/min. Vital signs included a temperature of 37.5°C (99.5°F), a heart rate of 92 beats per minute, and a respiratory rate of 20 breaths per minute, with oxygen saturation improving to 95% on room air. Auscultation still revealed bilateral wheezing, but the crackles had diminished, suggesting reduced mucus accumulation and improved bronchial dilation.

However, new complications emerged that required attention. The patient reported persistent fatigue and muscle weakness, which had not improved despite the adjustments in her corticosteroid regimen. Blood glucose levels were still elevated, with readings fluctuating between 160 mg/dL and 180 mg/dL, suggesting that the systemic effects of prednisone continued to impact her metabolism. In response, the healthcare team initiated a consultation with a dietitian to develop a tailored nutritional plan aimed at controlling her blood sugar levels through diet.

The patient also developed mild edema in her lower extremities, raising concerns about fluid retention possibly associated with corticosteroid use. The team decided to perform additional lab tests, including electrolytes and renal function tests, to rule out any renal involvement or electrolyte imbalances. These findings necessitated careful clinical reasoning to balance the management of her chronic asthma symptoms with the mitigation of side effects from her treatment regimen. The healthcare team planned to reassess her condition in another week, with the possibility of adjusting her medication dosages or introducing new therapies if necessary.