Depression, anxiety - Nursing Case Study
Pathophysiology
• Primary mechanism: Neurotransmitter imbalance - Depression and anxiety are primarily linked to imbalances in neurotransmitters such as serotonin, norepinephrine, and dopamine. These chemicals are crucial for regulating mood, emotion, and stress response. An imbalance can lead to mood disturbances and heightened anxiety.
• Secondary mechanism: HPA axis dysregulation - The hypothalamic-pituitary-adrenal (HPA) axis controls the body's reaction to stress. Chronic stress or dysregulation can lead to excessive cortisol release, contributing to anxiety and depression by affecting brain regions responsible for mood regulation.
• Key complication: Neuroplasticity changes - Prolonged exposure to stress and neurotransmitter imbalances can alter brain structure and function, impairing neuroplasticity. This can result in persistent mood disorders and reduced ability to adapt to new stressors, complicating recovery efforts.
Patient Profile
Demographics:
32-year-old female, graphic designer
History:
• Key past medical history: Depression diagnosed 2 years ago, generalized anxiety disorder diagnosed 1 year ago
• Current medications: Sertraline 100 mg daily, Alprazolam 0.5 mg as needed
• Allergies: Penicillin
Current Presentation:
• Chief complaint: Increased anxiety and depressive symptoms over the past month
• Key symptoms: Persistent sadness, fatigue, difficulty concentrating, increased heart palpitations, occasional shortness of breath, insomnia
• Vital signs: Blood pressure 138/90 mmHg, heart rate 102 bpm, respiratory rate 22 breaths per minute, temperature 98.6°F
Section 1
As the healthcare team continues to monitor the patient, there is a notable change in her status. Over the past week, the patient reports an increase in the frequency of heart palpitations and shortness of breath, which now occur multiple times a day. She also describes a persistent feeling of chest tightness, particularly during the late afternoon and evening. Her insomnia has worsened, with her experiencing difficulty falling and staying asleep, leading to increased fatigue during the day. The patient’s blood pressure has fluctuated, occasionally reaching levels as high as 145/95 mmHg.
In light of these developments, the healthcare team decides to conduct further diagnostic tests to better understand the underlying causes of her changing symptoms. An electrocardiogram (ECG) is performed to assess cardiac function, given the persistent palpitations and elevated heart rate. The results show frequent premature atrial contractions (PACs), which may be exacerbated by her anxiety and medication side effects. Additionally, a full blood panel is ordered to evaluate potential physiological contributors, revealing slightly elevated cortisol levels, indicative of ongoing HPA axis dysregulation. Thyroid function tests are also conducted to rule out any thyroid-related causes of her symptoms, which return within normal limits.
These findings prompt a reevaluation of the patient's current treatment plan. The team considers the potential need for an adjustment in her medication regimen, such as optimizing the dosage of Sertraline or considering an alternative SSRI, and emphasizes non-pharmacological interventions to address her heightened stress and anxiety. Cognitive-behavioral therapy (CBT) is recommended to help the patient develop coping strategies and reduce the impact of her anxiety on her daily life. This approach aims to enhance her overall treatment response by targeting both neurochemical and behavioral aspects of her condition.
Section 2
The healthcare team decides to prioritize implementing a comprehensive approach that integrates both pharmacological and non-pharmacological interventions. The patient's Sertraline dose is carefully adjusted under close monitoring, increasing it to 75 mg daily to better address her escalating symptoms of anxiety and depression. Meanwhile, the team initiates a structured cognitive-behavioral therapy (CBT) program, scheduling weekly sessions with a licensed therapist specializing in anxiety disorders. During the initial CBT sessions, the patient is guided to identify specific triggers of her anxiety and develop strategies to manage her physiological responses, such as deep breathing exercises and progressive muscle relaxation techniques.
Within a few weeks, there is a noticeable change in the patient’s condition. She reports a slight reduction in the frequency of her palpitations and shortness of breath, particularly in the evenings. Her sleep pattern shows marginal improvement, with occasional nights of uninterrupted rest. However, her blood pressure remains variable, fluctuating between 130/85 mmHg and 150/90 mmHg. This inconsistency suggests that while some progress is being made, additional factors may be contributing to her cardiovascular symptoms. The team considers the possibility of underlying autonomic dysregulation, likely influenced by her anxiety and stress levels, and discusses incorporating biofeedback therapy as an adjunctive treatment.
As the treatment progresses, the patient expresses an increased sense of control over her anxiety, feeling more equipped to handle daily stressors. However, she continues to experience episodes of fatigue, which affects her ability to engage fully in her daily activities and therapeutic exercises. This prompts the team to explore other potential contributors, such as nutritional deficiencies or sleep apnea, that might be compounding her fatigue. A sleep study is proposed to evaluate her nocturnal oxygen saturation and identify any disturbances that could be affecting her sleep quality. This multifaceted approach aims to address the intertwined aspects of her condition, guiding her toward a more balanced and sustainable recovery.
Section 3
As the comprehensive treatment plan unfolds, the healthcare team decides to proceed with the proposed sleep study to investigate the potential contribution of sleep disturbances to the patient’s persistent fatigue. The results reveal that the patient experiences mild obstructive sleep apnea, with an apnea-hypopnea index (AHI) of 8 events per hour, and occasional drops in nocturnal oxygen saturation to 88%. This finding provides a plausible explanation for her ongoing fatigue and suggests that her nightly rest may not be as restorative as previously assumed. Consequently, the team recommends the use of continuous positive airway pressure (CPAP) therapy to improve her sleep quality and reduce daytime fatigue.
In parallel, blood tests are conducted to assess for nutritional deficiencies that could be exacerbating her symptoms. The results indicate that the patient has a borderline low level of vitamin B12, with a serum concentration of 200 pg/mL, falling within the lower limit of normal. This finding prompts the team to initiate vitamin B12 supplementation, which could potentially alleviate some of her fatigue and enhance her overall energy levels. These interventions are carefully integrated into her ongoing treatment plan, ensuring that they complement her current pharmacological regimen and CBT sessions.
Over the following weeks, the patient begins to notice gradual improvements. With the introduction of CPAP therapy, she reports feeling slightly more refreshed upon waking, and her daytime fatigue shows a modest reduction. The vitamin B12 supplementation also seems to contribute positively, as she experiences fewer episodes of extreme tiredness. Nonetheless, the team remains vigilant, closely monitoring her response to these new therapies and maintaining open communication to adjust her treatment plan as necessary. This adaptive approach underscores the importance of addressing the multifaceted nature of her condition, paving the way for further progress in her journey toward recovery.
Section 4
As the weeks progress, the healthcare team closely monitors the patient's response to the interventions, particularly the CPAP therapy and vitamin B12 supplementation. During a routine follow-up visit, the patient reports that while her fatigue has improved, she is experiencing new and troubling symptoms. She describes a sense of restlessness, especially at night, with frequent urges to move her legs. Additionally, she mentions a creeping, uncomfortable sensation that often disrupts her sleep despite the CPAP therapy.
Taking these new complaints into account, the team suspects the possibility of Restless Legs Syndrome (RLS) as a contributing factor to her disrupted sleep. Further assessment reveals that her iron stores are on the low side, with a serum ferritin level of 20 ng/mL, which can be associated with RLS. Given these findings, the team decides to incorporate iron supplementation into her treatment plan, alongside her current therapies, to address this potential complication. Additionally, they adjust her CBT sessions to include strategies for managing anxiety related to sleep disturbances, aiming to optimize her overall sleep quality and mental health.
As the patient continues her journey, these integrated interventions offer a more comprehensive approach to her care. The team remains attentive to her evolving condition, ready to make further adjustments as needed. This highlights the importance of thorough clinical reasoning and the ability to adapt treatment plans based on emerging patient needs, ultimately steering her toward a more stable and improved quality of life.
Section 5
In the weeks following the addition of iron supplementation and adjusted CBT sessions, the patient initially reports some improvement in her symptoms of Restless Legs Syndrome, with a slight decrease in the frequency of night-time restlessness. However, during a subsequent follow-up appointment, she notes a new onset of palpitations and an intermittent feeling of lightheadedness, particularly in the mornings. These symptoms prompt the healthcare team to conduct a more detailed cardiac assessment, including an ECG, which reveals occasional premature ventricular contractions (PVCs). Her blood pressure is recorded at 118/76 mmHg, with a heart rate of 92 beats per minute, and a repeat serum ferritin level shows a modest increase to 35 ng/mL, indicating a response to the iron supplementation.
Given the new cardiac symptoms, the team considers the possibility of these being side effects of either the iron supplementation or an interaction with her existing medications. They decide to monitor the patient’s cardiac rhythm more closely and adjust her medication regimen, if necessary, to alleviate these symptoms. Additionally, they emphasize the importance of lifestyle modifications, such as maintaining a balanced diet and regular physical activity, to support her cardiovascular health and overall well-being.
As the team continues to navigate these evolving complexities, they remain vigilant in their clinical reasoning, ensuring that each aspect of the patient's care is carefully evaluated and adjusted. These efforts underscore the critical balance of managing physical symptoms while addressing the psychological components of her condition, aiming for a holistic improvement in her health status. The integration of ongoing assessments and interventions highlights the dynamic nature of patient care, as the team works collaboratively to steer the patient toward optimal health outcomes.