Diabetes - Nursing Case Study

Pathophysiology

• Primary mechanism: Insulin deficiency or resistance leads to impaired glucose uptake by cells, resulting in elevated blood glucose levels, essential in both Type 1 and Type 2 diabetes.

• Secondary mechanism: Chronic hyperglycemia causes damage to blood vessels and nerves, contributing to complications such as neuropathy and retinopathy.

• Key complication: Persistent high blood glucose levels increase the risk of cardiovascular diseases, as they accelerate the development of atherosclerosis.

Patient Profile

Demographics:

57-year-old female, office manager

History:

• Type 2 diabetes diagnosed 10 years ago, hypertension, hyperlipidemia

• Metformin 1000 mg twice daily, Lisinopril 20 mg daily, Atorvastatin 40 mg daily, Aspirin 81 mg daily

• Allergic to penicillin

Current Presentation:

• Chief complaint: Increasing fatigue and blurred vision

• Key symptoms: Numbness and tingling in feet, occasional dizziness, recent weight loss

• Vital signs: Blood pressure 145/90 mmHg, heart rate 92 bpm, respiratory rate 18 breaths per minute, temperature 98.6°F, fasting blood glucose 180 mg/dL

Section 1

New Diagnostic Results:

As part of the ongoing assessment and management of the patient's type 2 diabetes and associated symptoms, the healthcare team ordered a series of diagnostic tests to evaluate her current condition and identify potential complications. The results revealed that her Hemoglobin A1c level was 9.2%, indicating poor long-term glycemic control. Additionally, a lipid panel showed elevated LDL cholesterol at 160 mg/dL, total cholesterol at 240 mg/dL, and triglycerides at 210 mg/dL, suggesting that her hyperlipidemia is not adequately managed with her current atorvastatin therapy.

Further testing included a comprehensive metabolic panel, which showed a slightly elevated creatinine level of 1.4 mg/dL, hinting at potential early kidney involvement, likely diabetic nephropathy. Urinalysis revealed microalbuminuria, supporting this concern. The patient's symptoms of numbness and tingling in her feet were consistent with peripheral neuropathy, a common complication in diabetes due to prolonged hyperglycemia. An ophthalmologic examination confirmed the presence of mild non-proliferative diabetic retinopathy, correlating with her blurred vision.

These findings suggest that the patient's diabetes management plan needs re-evaluation. Her current symptoms and diagnostic results point towards the need for intensified blood glucose control and a potential adjustment in her antihypertensive and lipid-lowering medications. The healthcare team considered the initiation of insulin therapy and potential adjustments to her current lifestyle and dietary habits to address these complications effectively. The results highlight the importance of comprehensive management in preventing further progression of diabetic complications and underscore the need for regular monitoring and follow-up care.

Section 2

After reviewing the new diagnostic results, the healthcare team decided to implement changes to the patient's management plan, focusing on intensified glycemic control to mitigate the risk of further complications. Insulin therapy was initiated, starting with a basal insulin regimen using insulin glargine. Alongside this, the patient's oral hypoglycemic agents were adjusted, increasing the dose of metformin while adding a sodium-glucose co-transporter-2 (SGLT2) inhibitor to help manage both her blood glucose levels and provide renal protective benefits. The patient was counseled on the importance of adhering to her medication regimen and educated on potential side effects of insulin, such as hypoglycemia, and the signs and symptoms to watch for.

In addition to pharmacological adjustments, the patient's dietary and lifestyle modifications were revisited. A consultation with a dietitian was arranged to tailor a meal plan focusing on reduced carbohydrate intake, emphasizing high fiber and low glycemic index foods to aid in better glycemic control. Physical activity was encouraged, with a recommendation of at least 150 minutes of moderate-intensity exercise per week, tailored to her current capabilities and safety considerations given her peripheral neuropathy.

Two weeks into the new management plan, the patient returned for follow-up. She reported feeling more energized and had begun incorporating brisk walking into her daily routine. Her fasting blood glucose levels had decreased to an average of 130 mg/dL, showing improvement. However, she experienced occasional mild hypoglycemic episodes, particularly in the late afternoon, underscoring the need for ongoing monitoring and potential further adjustment of her insulin dosage. The lipid panel was repeated, showing a slight reduction in LDL cholesterol to 150 mg/dL, indicating a positive response to dietary changes and the adjusted atorvastatin dosage. Despite these improvements, the patient's blood pressure remained elevated at 150/90 mmHg, suggesting the need for further evaluation and potential modification of her antihypertensive therapy. These developments highlight the dynamic nature of managing type 2 diabetes and the necessity for continuous reassessment and individualized care.

Section 3

Two weeks later, the patient returned to the clinic with new concerns. Despite improved glycemic control, she reported experiencing increased frequency and severity of postural dizziness and persistent fatigue, which she had initially attributed to her lifestyle changes. These symptoms prompted a thorough reassessment, including a review of her current medication regimen, dietary intake, and hydration status. A physical examination revealed orthostatic hypotension, with her blood pressure dropping from 150/90 mmHg when seated to 120/80 mmHg upon standing. These findings suggested potential side effects of her adjusted antihypertensive therapy or possible volume depletion.

The healthcare team ordered additional laboratory tests to investigate the underlying causes of her symptoms. Serum electrolytes were within normal limits, but her renal function tests indicated a slight increase in serum creatinine to 1.4 mg/dL from a baseline of 1.0 mg/dL, raising concerns about the renal effects of her current medication regimen, including the newly added SGLT2 inhibitor. Furthermore, her hemoglobin level had dropped slightly to 11.5 g/dL, hinting at potential anemia that could contribute to her fatigue and dizziness.

In light of these findings, the team decided to adjust her antihypertensive therapy by reducing the dose of her diuretic to mitigate the risk of orthostatic hypotension and potential dehydration. A referral to a nephrologist was also made to evaluate her renal function further and assess the appropriateness of continuing the SGLT2 inhibitor. The team emphasized the importance of maintaining adequate hydration, monitoring blood pressure regularly, and reporting any significant changes in her condition. This phase of the patient's journey underscores the complexity of managing type 2 diabetes, as interventions aimed at improving one aspect of health can inadvertently impact others, necessitating a careful balance and ongoing reevaluation of her treatment plan.

Section 4

Two weeks following the adjustments to her treatment plan, the patient returned to the clinic for a follow-up visit. Her primary concerns had shifted, as she now reported experiencing intermittent episodes of palpitations, along with persistent fatigue that had not improved despite increased hydration and dietary adjustments. Upon examination, her vital signs revealed a resting heart rate of 98 beats per minute, which elevated to 115 beats per minute upon standing, along with a blood pressure reading of 118/78 mmHg sitting and 108/70 mmHg standing. These findings suggested an exacerbation of her orthostatic changes, possibly indicating an evolving autonomic neuropathy, a complication of diabetes that can affect cardiovascular regulation.

The healthcare team proceeded with further diagnostic evaluation to explore these new symptoms. An ECG was performed, showing sinus tachycardia but no other acute changes. Given the concern for autonomic dysfunction, a tilt table test was considered to assess the extent of her orthostatic intolerance more comprehensively. Additionally, a repeat hemoglobin test showed a further drop to 10.8 g/dL, prompting consideration of underlying causes such as iron deficiency or chronic disease anemia. Her renal function remained stable, with a creatinine level of 1.3 mg/dL, suggesting that the initial concerns related to her SGLT2 inhibitor might have been mitigated by her increased fluid intake and adjusted medication.

In response to these findings, the team decided to initiate a low-dose beta-blocker to manage her tachycardia and provide symptomatic relief from palpitations, while ensuring her blood pressure was closely monitored to prevent exacerbation of hypotension. A referral to a cardiologist was made to further evaluate her cardiac status and assess potential autonomic involvement. This development highlights the interconnectedness of diabetes-related complications and the necessity for a multidisciplinary approach to address the evolving clinical picture, emphasizing the need for vigilance and adaptability in managing complex cases like hers.

Section 5

Two weeks later, the patient returned for another follow-up visit, reporting that her palpitations had diminished since starting the low-dose beta-blocker. However, she continued to experience significant fatigue and had developed new symptoms, including mild dizziness and occasional blurred vision. Her vital signs during this visit showed a heart rate of 85 beats per minute at rest, which was an improvement, but her orthostatic changes persisted, with a blood pressure of 110/72 mmHg sitting and 98/64 mmHg standing. These findings raised concerns about the ongoing impact of potential autonomic neuropathy and the need for further evaluation of her cardiovascular responses.

The tilt table test conducted by the cardiologist revealed a significant drop in blood pressure upon standing, confirming the presence of postural orthostatic tachycardia syndrome (POTS), a condition often associated with autonomic dysfunction in diabetes patients. Additionally, a detailed blood panel was performed, which indicated low serum ferritin levels of 20 ng/mL, suggesting iron deficiency anemia as a contributing factor to her persistent fatigue and dizziness. These results prompted an adjustment in her treatment plan, with the initiation of oral iron supplementation to address her anemia, alongside continued monitoring of her cardiovascular status and further investigation into any potential gastrointestinal sources of blood loss.

This new information underscored the need for an integrated approach to her care, focusing on both managing her diabetes and addressing the broader spectrum of complications. The healthcare team emphasized the importance of regular follow-up visits to monitor her response to interventions and adjust her treatment plan as necessary. They also reinforced the potential need for dietary adjustments, ensuring adequate iron intake, and exploring lifestyle modifications to help manage her symptoms more effectively. This case highlights the complexity of diabetes management and the critical role of ongoing assessment and adaptation in achieving optimal patient outcomes.