Diabetes - Nursing Case Study
Pathophysiology
• Primary mechanism: Insulin resistance - In type 2 diabetes, cells in muscles, fat, and the liver become less responsive to insulin, reducing glucose uptake and increasing blood sugar levels. This resistance is often linked to obesity and physical inactivity.
• Secondary mechanism: Impaired insulin secretion - The pancreas struggles to produce enough insulin to overcome the resistance, leading to progressively higher blood glucose levels. Beta-cell dysfunction is a critical factor here, which may worsen over time.
• Key complication: Hyperglycemia - Persistently high blood sugar can cause damage to blood vessels and nerves, increasing the risk of cardiovascular disease, neuropathy, retinopathy, and nephropathy, impacting overall health and quality of life.
Patient Profile
Demographics:
54-year-old male, office manager
History:
• Key past medical history: Type 2 Diabetes diagnosed 6 years ago, hypertension, hyperlipidemia
• Current medications: Metformin 1000 mg twice daily, Lisinopril 10 mg daily, Atorvastatin 20 mg daily, Aspirin 81 mg daily
• Allergies: Penicillin
Current Presentation:
• Chief complaint: Increasing fatigue and tingling sensation in feet
• Key symptoms: Polyuria, polydipsia, blurred vision, intermittent headaches, occasional dizziness
• Vital signs: Blood pressure 145/90 mmHg, heart rate 88 bpm, respiratory rate 18 breaths per minute, temperature 98.6°F, BMI 31 kg/m²
Section 1
As the clinical team conducts an initial assessment of the patient's condition, several key findings emerge that warrant further investigation. The patient's hemoglobin A1c (HbA1c) level is reported at 9.2%, indicating poor long-term glycemic control. This aligns with the patient's symptoms of blurred vision and polyuria, suggesting chronic hyperglycemia. Additionally, a comprehensive foot examination reveals decreased sensation in the toes and the presence of calluses, raising concerns about diabetic neuropathy and potential risk for foot ulcers. The patient's blood pressure remains elevated at 145/90 mmHg despite current antihypertensive therapy, highlighting the need for more aggressive management of hypertension to mitigate cardiovascular risks.
In light of these findings, the healthcare team prioritizes the need for targeted interventions to address the patient's uncontrolled diabetes and associated complications. An adjustment in the patient's medication regimen is considered, potentially incorporating a GLP-1 receptor agonist or SGLT2 inhibitor to enhance glycemic control and provide additional cardiovascular benefits. The patient is also advised to monitor blood glucose levels more frequently and is referred to a diabetes educator for dietary counseling and lifestyle modification support. Regular follow-up appointments are scheduled to closely monitor the patient's response to these interventions and to assess for any further progression of complications.
These developments in the patient's care plan highlight the importance of a multifaceted approach in managing type 2 diabetes and its complications. The healthcare team must employ clinical reasoning to balance the risks and benefits of pharmacological adjustments, while also emphasizing the critical role of patient education and lifestyle changes. This integrated strategy aims to improve the patient's quality of life and prevent the onset of further complications, such as diabetic retinopathy or nephropathy, as part of a comprehensive chronic disease management plan.
Section 2
Three months into the patient's revised care plan, the healthcare team conducts a follow-up assessment to evaluate the response to the interventions. Encouragingly, the patient's HbA1c level has decreased to 7.8%, indicating improved glycemic control, although there is still room for further improvement. The patient reports adherence to the prescribed GLP-1 receptor agonist and has been actively participating in dietary counseling sessions. However, the patient notes occasional episodes of dizziness and fatigue, prompting further investigation.
Vital signs reveal a blood pressure of 135/85 mmHg, showing some improvement but still not within the optimal range. Additionally, a recent lipid panel indicates elevated LDL cholesterol levels at 145 mg/dL, despite ongoing statin therapy. This presents a renewed focus on cardiovascular risk management, necessitating a potential adjustment in lipid-lowering medications. Meanwhile, the foot examination shows no new ulcers, but persistent calluses require ongoing monitoring and preventive care.
The patient's dizziness and fatigue raise concerns about potential hypoglycemia episodes, possibly linked to the recent pharmacological adjustments. The healthcare team considers these symptoms in conjunction with the improved HbA1c, recognizing the need to fine-tune the medication regimen to balance efficacy and safety. This situation underscores the importance of ongoing evaluation and individualized care, emphasizing the dynamic nature of diabetes management. The team plans to continue close monitoring and education, reinforcing the patient's role in self-management as they work to further reduce cardiovascular and neuropathic risks.
Section 3
Three weeks after the follow-up assessment, the patient experiences an episode of severe dizziness accompanied by palpitations and confusion, prompting an urgent visit to the clinic. During the initial assessment, the healthcare team records a blood pressure of 128/82 mmHg and a heart rate of 110 beats per minute. The patient's fasting blood glucose is measured at 62 mg/dL, confirming a hypoglycemic event. This finding triggers a review of the patient's current medication regimen, particularly the dosage of the GLP-1 receptor agonist, and the potential need for adjustments to prevent future episodes. The team also investigates the patient's dietary intake, identifying occasional missed meals as a contributing factor to the hypoglycemia.
Further examination reveals a slight increase in the patient's creatinine level to 1.3 mg/dL, raising concerns about renal function that may impact medication metabolism. The healthcare provider orders additional renal function tests and discusses the importance of regular meal consumption with the patient to stabilize blood glucose levels. They also emphasize staying hydrated, particularly given the warmer weather, which can exacerbate symptoms of dizziness and fatigue.
Acknowledging the interconnected nature of diabetes management, the team decides to temporarily reduce the GLP-1 receptor agonist dosage while closely monitoring the patient's blood glucose levels over the next several weeks. They reinforce the importance of routine blood glucose monitoring, especially before and after physical activity, to detect potential hypoglycemic trends early. The patient is scheduled for a follow-up appointment in two weeks to re-evaluate renal function and ensure the adjustments are effectively balancing glycemic control without further episodes of hypoglycemia.
Section 4
Two weeks later, the patient returns for the scheduled follow-up appointment. Upon initial assessment, the nurse notes that the patient appears slightly more fatigued and reports mild swelling in the lower extremities, which had not been present at the previous visit. Vital signs indicate a blood pressure of 130/84 mmHg and a heart rate of 108 beats per minute, both slightly elevated from the previous readings. The patient's fasting blood glucose is now 78 mg/dL, showing improvement but still on the lower end of the normal range. The patient mentions adhering more strictly to meal timing, though admits to occasional difficulties due to an irregular work schedule.
Laboratory results from the renal function tests indicate a further increase in creatinine to 1.5 mg/dL, along with a slight elevation in blood urea nitrogen (BUN) levels, suggesting a possible decline in kidney function. These findings prompt the healthcare team to consider the potential impact of the GLP-1 receptor agonist and other medications on renal health. The team discusses the importance of appropriate medication dosing and the need to address any factors that may exacerbate renal strain, such as dehydration or uncontrolled blood pressure.
Given these developments, the healthcare provider emphasizes the importance of maintaining hydration and possibly modifying the patient's diet to include foods that support kidney health. They consider consulting a nephrologist for further evaluation and exploring alternative diabetes management strategies that are less taxing on the kidneys. The patient is advised to continue regular monitoring of blood glucose levels and to report any new symptoms immediately. The healthcare team schedules another follow-up in two weeks to reassess the patient's renal function and overall status, ensuring the care plan remains responsive to the evolving clinical picture.
Section 5
Two weeks later, the patient returns for another follow-up appointment. During the initial assessment, the nurse observes that the patient appears more lethargic and has developed noticeable periorbital puffiness, suggesting worsening fluid retention. The patient reports feeling increasingly tired and experiencing occasional headaches, which they previously attributed to stress. Vital signs reveal a blood pressure of 138/90 mmHg, indicating a further increase from the last visit, and a heart rate of 112 beats per minute. The patient's fasting blood glucose remains stable at 82 mg/dL, but the nurse notes a weight gain of 4 pounds since the last visit, likely related to fluid accumulation.
The healthcare team reviews new laboratory results, which show a creatinine level that has risen to 1.7 mg/dL and a further increase in BUN to 28 mg/dL. Additionally, the patient's estimated glomerular filtration rate (eGFR) has decreased, reflecting a more significant decline in renal function. Urinalysis reveals trace proteinuria, which raises concerns about the onset of diabetic nephropathy. These findings prompt the team to reassess the current medication regimen, considering the potential nephrotoxic effects of the GLP-1 receptor agonist and any other contributing factors.
In response to the patient's deteriorating renal function and rising blood pressure, the healthcare provider decides to adjust the diabetes management plan. They initiate a consultation with a nephrologist to explore further diagnostic evaluations and potential adjustments in medication. Additionally, the provider emphasizes the importance of strict blood pressure control and recommends starting an ACE inhibitor, known to provide renal protective benefits in diabetic patients. The patient is educated on the importance of consistent fluid intake, adherence to dietary modifications, and the need to immediately report any further symptoms such as increased swelling or changes in urinary patterns. The team schedules another follow-up in one week to closely monitor the patient's renal function and overall health, ensuring timely adjustments to the care plan as needed.