diabetes - Nursing Case Study
Pathophysiology
• Primary mechanism: Insulin deficiency/resistance - In Type 1 diabetes, autoimmune destruction of pancreatic beta cells leads to insufficient insulin production. In Type 2 diabetes, cells exhibit insulin resistance, reducing glucose uptake despite adequate insulin levels.
• Secondary mechanism: Hyperglycemia - Resulting from impaired insulin action, glucose accumulates in the bloodstream, as cells cannot effectively use it for energy, leading to elevated blood sugar levels.
• Key complication: Vascular damage - Chronic hyperglycemia causes damage to blood vessels, increasing the risk of cardiovascular disease, neuropathy, nephropathy, and retinopathy, highlighting the importance of glycemic control.
Patient Profile
Demographics:
58 years old, male, construction worker
History:
• Type 2 Diabetes diagnosed 8 years ago, hypertension, dyslipidemia
• Metformin 1000 mg twice daily, Lisinopril 10 mg daily, Atorvastatin 20 mg daily, Insulin glargine 20 units at bedtime
• Allergic to penicillin
Current Presentation:
• Chief complaint: Increasing fatigue and blurred vision
• Key symptoms: Polyuria, polydipsia, tingling in feet, occasional dizziness
• Vital signs: Blood pressure 145/90 mmHg, heart rate 88 bpm, respiratory rate 18 breaths per minute, temperature 98.6°F, BMI 32 kg/m²
Section 1
Upon initial assessment, the patient's condition reveals several areas of concern that warrant further investigation. Physical examination notes the presence of bilateral peripheral neuropathy, as indicated by diminished sensation in the feet upon monofilament testing. Additionally, there is evidence of early diabetic retinopathy, with retinal examination revealing microaneurysms and mild non-proliferative changes. Laboratory results show a fasting blood glucose level of 210 mg/dL and an HbA1c of 9.2%, indicating suboptimal glycemic control. Creatinine levels are slightly elevated at 1.4 mg/dL, suggesting the onset of diabetic nephropathy, while urine microalbumin levels are elevated at 45 mg/L, further substantiating this finding.
These assessment findings highlight the progression of diabetes-related complications, emphasizing the need for a revised management plan to address both hyperglycemia and its sequelae. The presence of diabetic neuropathy and nephropathy indicates microvascular damage, likely exacerbated by poor blood pressure and lipid control. The patient's current medication regimen may need adjustment, potentially increasing insulin dosage or adding a GLP-1 receptor agonist, to achieve better glycemic control and mitigate further vascular damage. Additionally, the development of retinopathy necessitates referral to an ophthalmologist for comprehensive eye care.
Given these findings, it is clear that the patient requires a multifaceted approach to management, integrating lifestyle modifications with pharmacological interventions. Emphasis should be placed on dietary counseling, regular physical activity, and smoking cessation to enhance cardiovascular health. The healthcare team must engage in regular monitoring and follow-up to assess the effectiveness of interventions, address any barriers to adherence, and prevent the progression of complications. This integrated strategy will be critical in improving the patient's quality of life and preventing further deterioration of health.
Section 2
Following the initial assessment and implementation of a revised management plan, the patient returns for a follow-up appointment six weeks later. During this visit, the healthcare team notes a mild improvement in glycemic control, with the patient's fasting blood glucose level now at 180 mg/dL and HbA1c reduced to 8.6%. Despite these advancements, the patient reports persistent tingling and numbness in the feet, with increased difficulty in maintaining balance, particularly when walking on uneven surfaces. These symptoms suggest a progression of peripheral neuropathy, prompting further evaluation and consideration of additional interventions.
A comprehensive neurological examination reveals worsened proprioception and an increase in the monofilament test score, indicating heightened sensory loss. Furthermore, new laboratory results show a slight increase in serum creatinine to 1.6 mg/dL, alongside the continued presence of elevated urine microalbumin at 55 mg/L. These findings suggest progression in diabetic nephropathy, necessitating a reassessment of renal protective strategies, including the potential introduction of an ACE inhibitor or ARB to manage blood pressure and minimize kidney damage.
In response to these developments, the healthcare team decides to intensify the patient's treatment regimen. This includes optimizing the current pharmacological approach by considering the addition of a sodium-glucose co-transporter-2 (SGLT2) inhibitor, which has demonstrated renal protective effects and may further improve glycemic control. The patient is also referred to a podiatrist for specialized foot care and to a physical therapist to address balance issues through targeted exercises. These adjustments aim to slow the progression of complications, improve the patient's functional capacity, and enhance overall quality of life. Regular follow-ups are planned to monitor progress and ensure adherence to the revised management strategy.
Section 3
Three months after the intensified treatment regimen was implemented, the patient returns for another follow-up appointment. During this visit, the healthcare team observes a notable improvement in the patient's glycemic control, as evidenced by a fasting blood glucose level reduced to 150 mg/dL and an HbA1c of 7.9%. Despite these positive changes, the patient reports occasional dizziness and lightheadedness, especially upon standing, which raises concerns about potential orthostatic hypotension. A review of the patient's current medications reveals the recent addition of an ACE inhibitor to manage diabetic nephropathy, which may be contributing to these symptoms.
A thorough assessment is conducted, including vital signs taken in both supine and standing positions. The patient's blood pressure is 125/80 mmHg while lying down but drops to 100/70 mmHg upon standing, confirming the presence of orthostatic hypotension. Additionally, the neurological examination shows mild improvement in proprioception and a slight decrease in the monofilament test score, suggesting some stabilization of peripheral neuropathy symptoms. However, the patient's serum creatinine remains at 1.6 mg/dL, with urine microalbumin slightly reduced to 50 mg/L, indicating that renal function has not significantly worsened.
Based on these findings, the healthcare team decides to adjust the patient's medication regimen to address the orthostatic hypotension while continuing to provide renal protection. The dosage of the ACE inhibitor is reviewed and adjusted cautiously, and the patient is educated on lifestyle modifications such as rising slowly from sitting or lying positions and maintaining adequate hydration. The team also emphasizes the importance of ongoing monitoring of blood pressure and renal function, with plans for regular follow-ups to ensure the patient remains stable and to assess the effectiveness of the revised management plan. This approach aims to balance the management of existing complications while minimizing the risk of new side effects, guiding the patient toward improved stability and quality of life.
Section 4
Two months after the adjustments to the patient's medication regimen, the patient returns for a scheduled follow-up appointment. During this visit, the healthcare team notes that the patient’s orthostatic hypotension symptoms have slightly improved, with blood pressure readings now showing 120/78 mmHg while supine and 108/74 mmHg upon standing. The patient reports fewer episodes of dizziness and lightheadedness, indicating a positive response to the modifications in medication and lifestyle adjustments.
However, new concerns arise as the patient describes experiencing more frequent episodes of numbness and tingling in their feet, particularly at night. A detailed neurological examination reveals diminished vibratory sensation and a further decrease in the monofilament test score, suggesting a progression of peripheral neuropathy despite stable glycemic control. Additionally, recent lab results show a slight increase in serum creatinine to 1.8 mg/dL, raising concerns about potential renal function decline, even though urine microalbumin levels remain stable.
The healthcare team recognizes the need for further intervention to address these emerging complications. They discuss the possibility of introducing a medication specifically aimed at neuropathic pain management, such as a gabapentinoid, while continuing to monitor renal function closely. Education is reinforced around foot care and the importance of regular exercise to improve circulation. Scheduled follow-ups are planned to reassess the effectiveness of the new interventions and to ensure comprehensive management of the patient’s diabetes and associated complications. Through careful monitoring and tailored interventions, the team aims to prevent further progression of complications and enhance the patient's quality of life.
Section 5
Two weeks after the introduction of the gabapentinoid for neuropathic pain management, the patient returns for a follow-up appointment. Initially, the patient reports a noticeable reduction in the intensity and frequency of numbness and tingling in their feet, indicating a positive response to the medication. However, the patient also mentions experiencing increased fatigue and occasional difficulty concentrating, which raises concerns about possible side effects of the new medication. The healthcare team decides to adjust the gabapentinoid dosage to balance efficacy with tolerability, while also considering non-pharmacological interventions such as physical therapy to support nerve health and function.
During this visit, a repeat set of laboratory tests is conducted to monitor renal function and overall metabolic status. The results reveal a slight increase in serum creatinine to 2.0 mg/dL, suggesting a continuing decline in renal function. In addition, a new finding of a trace amount of protein in the urine indicates early signs of nephropathy. These results prompt the healthcare team to re-evaluate the patient's medication regimen, particularly the use of any nephrotoxic agents, and to reinforce the importance of optimal blood pressure and glycemic control to preserve kidney function.
The patient is counseled on dietary modifications, such as reducing sodium and protein intake, to alleviate stress on the kidneys. The team emphasizes the importance of maintaining a balanced diet and regular physical activity to manage weight and improve circulation, which is critical for both neuropathy and kidney health. Follow-up appointments are scheduled more frequently to closely monitor the patient's progress and to adjust treatment plans as needed. Through a proactive and holistic approach, the healthcare team aims to mitigate further complications and support the patient's overall well-being.