Seizure - Nursing Case Study
Pathophysiology
• Primary mechanism: Neuronal hyperexcitability - Seizures occur due to excessive electrical discharge in the brain, often triggered by an imbalance between excitatory and inhibitory neurotransmitters, leading to sustained neuronal firing.
• Secondary mechanism: Altered ion channel function - Dysfunctional sodium, calcium, or potassium ion channels can disrupt the regulation of neuronal excitability, contributing to the initiation and propagation of seizure activity.
• Key complication: Status epilepticus - Prolonged or recurrent seizures without recovery between episodes can lead to neuronal injury, increased metabolic demands, and potential long-term neurological damage if not promptly managed.
Patient Profile
Demographics:
42-year-old female, high school teacher
History:
• Key past medical history: Epilepsy diagnosed at age 30, hypertension
• Current medications: Lamotrigine 200 mg twice daily, Lisinopril 10 mg daily
• Allergies: Penicillin
Current Presentation:
• Chief complaint: Increased frequency of seizures over the past month
• Key symptoms: Generalized tonic-clonic seizures, confusion post-seizure, occasional headaches
• Vital signs: Blood pressure 150/95 mmHg, heart rate 88 bpm, respiratory rate 22 breaths per minute, temperature 98.6°F
Section 1
As the nurse conducts an initial assessment, the patient's condition reveals several notable findings. The patient is mildly confused and disoriented, consistent with postictal state, and reports a persistent, dull headache. Neurological examination shows slight weakness in her right arm, which was not previously documented, raising concerns about possible focal neurological deficits. Her blood pressure remains elevated at 155/98 mmHg, and her respiratory rate is slightly tachypneic at 24 breaths per minute. These findings suggest that the patient may be experiencing an increased seizure burden, potentially progressing towards status epilepticus. Further evaluation is necessary to determine if these are indicative of ongoing neuronal injury or other complications.
Laboratory tests and imaging are promptly ordered to explore underlying causes for the change in her clinical status. An electroencephalogram (EEG) is obtained, showing continuous epileptiform activity, which confirms the diagnosis of non-convulsive status epilepticus. Blood tests reveal elevated white blood cell count and a slight increase in serum creatinine, suggesting a possible infectious process or renal involvement. Additionally, serum electrolytes indicate mild hyponatremia, which could be contributing to the increased seizure frequency. These findings necessitate immediate intervention to prevent further complications and stabilize the patient.
The healthcare team decides to initiate an intravenous infusion of lorazepam to control the ongoing seizure activity and address the non-convulsive status epilepticus. The patient is also started on a sodium supplement to correct the hyponatremia. A CT scan is scheduled to rule out any acute intracranial pathology, such as hemorrhage or mass effect, that might be responsible for the new focal weakness. The team anticipates that these interventions will stabilize the patient and provide a clearer picture of her neurological status, guiding further treatment decisions. With these measures in place, the team prepares for potential escalation of care, should the patient's condition not improve promptly.
Section 2
As the team monitors the patient's response to the initial interventions, there are notable changes in her clinical status. Within an hour of starting the intravenous lorazepam infusion, her seizure activity begins to decrease, as observed in her EEG, which shows a reduction in epileptiform discharges. However, despite the improvement in seizure control, the patient's mental status remains altered, with persistent confusion and disorientation. Her right arm weakness has not resolved, and there is now a subtle droop on the right side of her face, suggesting a possible new neurological event.
The CT scan results return, revealing no acute intracranial hemorrhage or significant mass effect, which is reassuring. However, it does show signs of chronic small vessel ischemic changes, which may not entirely explain the new focal deficits. With these findings, the team considers the possibility of a transient ischemic attack (TIA) or a minor stroke, potentially exacerbated by the elevated blood pressure and ongoing seizures. The blood pressure remains at 160/100 mmHg, despite initial measures to control it, prompting the initiation of antihypertensive therapy to mitigate further cerebrovascular risk.
Simultaneously, the laboratory team reports a culture growth from the blood samples taken earlier, indicating a low-grade bacterial infection, which could be contributing to the elevated white blood cell count and possibly the mild acute kidney injury. The patient is started on broad-spectrum antibiotics while awaiting specific sensitivity results. The multidisciplinary team discusses the need for continued close monitoring and potential escalation to more aggressive therapies if the patient's neurological status does not improve or if further complications arise. This comprehensive approach aims to address both the immediate threats to the patient's health and the underlying conditions contributing to her current state, guiding the next steps in her care journey.
Section 3
As the multidisciplinary team continues to monitor the patient's condition, her response to the initial interventions reveals a notable change in her status. Early in the morning, the nursing staff observes that the patient's level of consciousness has slightly improved; she is now intermittently alert and able to follow simple commands, although still confused. However, a new complication arises: the patient begins to exhibit signs of aspiration, with episodes of coughing and difficulty swallowing noted during attempts to administer oral medications. Concerned about her airway protection, the team decides to temporarily withhold oral intake and considers the need for a swallow evaluation by a speech-language pathologist. This alteration prompts reevaluation of her respiratory status, as her oxygen saturation dips to 90% on room air, necessitating supplemental oxygen via nasal cannula to maintain adequate levels.
Concurrent with these developments, the patient's laboratory results reveal a worsening of her renal function, with serum creatinine rising to 2.1 mg/dL from an initial 1.7 mg/dL. The electrolyte panel indicates mild hyponatremia, with a sodium level of 131 mEq/L, potentially contributing to her altered mental status. These findings suggest that the acute kidney injury may be exacerbating her clinical picture and require careful management of fluid balance and medication dosing. The team reviews her current medications, particularly the ongoing antihypertensive therapy, to assess the impact on her renal function and adjust treatment as necessary.
Given the evolving complexity of the patient's condition, including the new aspiration risk and renal impairment, the team considers the need for a more comprehensive neurological evaluation and potential transfer to a higher level of care for closer monitoring. As they deliberate on these options, they emphasize the importance of ongoing communication with the family to ensure they are informed and involved in the decision-making process. The next steps in the patient's care will focus on stabilizing her respiratory and renal function while continuing to address the underlying causes of her neurological deficits.
Section 4
As the healthcare team continues to address the patient's condition, a new diagnostic result emerges that provides further insight into her complicated clinical picture. The speech-language pathologist conducts a detailed swallow evaluation and confirms that the patient has dysphagia with a high risk of aspiration, indicating the need for enteral feeding via a nasogastric tube to ensure nutritional support while protecting her airway. This finding necessitates a modification in her care plan, focusing on preventing aspiration pneumonia and ensuring adequate nutritional intake without exacerbating her respiratory status.
Meanwhile, the nephrology team is consulted to manage the patient's acute kidney injury. A review of her medication regimen reveals that one of her antihypertensive medications, an ACE inhibitor, may be contributing to her declining renal function. The team decides to temporarily hold this medication and substitute it with an alternative agent that poses less risk to her kidneys. Additionally, they implement a fluid management plan aimed at carefully balancing hydration to support renal recovery while avoiding fluid overload, which could compromise her respiratory status further.
In light of these developments, the multidisciplinary team continues to monitor her closely, noting that her oxygen saturation has improved to 94% with supplemental oxygen. However, her mental status remains variable, characterized by periods of alertness interspersed with confusion, likely influenced by her electrolyte imbalances. The team plans for further neurological evaluation, including a CT scan to rule out any acute intracranial processes. They also emphasize the need for regular communication with the patient's family, ensuring they understand the complexity of her condition and the rationale behind the evolving care plan. This ongoing engagement is crucial as the team considers the possibility of transferring the patient to a step-down unit for enhanced monitoring and care.
Section 5
As the multidisciplinary team continues to manage the patient's complex condition, a new change in her status emerges. During the morning rounds, the nurse notes that the patient's heart rate has increased to 110 beats per minute, and her blood pressure reads 148/92 mmHg. Despite adjustments to her medication regimen, these vital signs indicate a hemodynamic imbalance that requires immediate attention. Concurrently, the patient's respiratory rate has risen to 24 breaths per minute, suggesting increased work of breathing, possibly due to fluid shifts or the onset of an infection. Her oxygen saturation remains stable at 93% on 2 liters of supplemental oxygen, but the team remains vigilant about the risk of respiratory compromise.
The patient's laboratory results reveal an elevated white blood cell count of 14,000/mm³, raising suspicion for an infectious process, potentially aspiration pneumonia given her recent dysphagia diagnosis. Additionally, her serum creatinine level shows a slight improvement, now at 2.1 mg/dL, indicating a positive response to the modified renal management plan. However, her potassium level is now at 3.2 mEq/L, reflecting hypokalemia that could be contributing to her tachycardia and necessitating careful repletion. The nephrology team adjusts her electrolyte management plan, emphasizing the need for cardiac monitoring in light of her electrolyte imbalances.
In response to these developments, the team discusses the potential benefits of transferring the patient to a step-down unit, where she can receive more focused monitoring and interventions to address her hemodynamic and respiratory needs. The plan includes initiating empirical antibiotics to address the suspected infection while awaiting culture results, continued close monitoring of her renal function, and adjusting her antihypertensive therapy to achieve better blood pressure control without compromising kidney function. The team also plans to engage in another round of family discussions to update them on the patient's current status and the rationale behind the proposed transfer, ensuring they remain informed partners in her care journey.