lung cancer - Nursing Case Study
Pathophysiology
• Primary mechanism: Lung cancer primarily arises from genetic mutations in lung epithelial cells, often due to carcinogen exposure (e.g., tobacco smoke), leading to uncontrolled cell proliferation and tumor formation.
• Secondary mechanism: Tumor cells can bypass normal cell death processes through mutations in genes regulating apoptosis, allowing them to survive and accumulate, further promoting tumor growth and potential metastasis.
• Key complication: As the tumor grows, it can invade surrounding tissues and spread to distant organs (metastasis), leading to systemic effects like impaired lung function, difficulty breathing, and reduced oxygen exchange, significantly impacting patient quality of life.
Patient Profile
Demographics:
58-year-old female, former coal miner
History:
• Key past medical history: Hypertension, chronic obstructive pulmonary disease (COPD)
• Current medications: Lisinopril, Albuterol inhaler, Fluticasone propionate nasal spray
• Allergies: Penicillin
Current Presentation:
• Chief complaint: Persistent cough and shortness of breath
• Key symptoms: Weight loss, fatigue, hemoptysis, chest pain
• Vital signs: Blood pressure 145/90 mmHg, heart rate 102 bpm, respiratory rate 22 breaths per minute, temperature 99.1°F, oxygen saturation 89% on room air
Section 1
As the medical team continues to evaluate the patient, new diagnostic results reveal a large mass in the right upper lobe of her lung, confirmed by a CT scan. The imaging also shows evidence of mediastinal lymph node enlargement, suggesting possible spread of the cancer. A bronchoscopy with biopsy is performed, and the pathology report confirms non-small cell lung cancer (NSCLC), squamous cell carcinoma subtype. Laboratory tests indicate elevated calcium levels and slight anemia, which are consistent with paraneoplastic syndromes often associated with lung cancer. The patient's oxygen saturation continues to remain low, despite supplemental oxygen, indicating a significant impairment in respiratory function.
In response to these findings, the oncology team discusses potential treatment options with the patient, including chemotherapy and radiation therapy. However, given her COPD and current respiratory compromise, the team must carefully consider her pulmonary function and quality of life when planning treatment. The patient's history as a coal miner and her significant exposure to carcinogens are discussed as contributing factors to her condition, reinforcing the need to address occupational health in cancer prevention strategies.
As the patient processes her diagnosis and treatment options, she begins to experience increased anxiety and a sense of hopelessness, which can further impact her overall health and ability to manage her condition. The healthcare team, including nursing staff, focuses on providing comprehensive care that addresses her physical symptoms and emotional well-being. They offer support through counseling services and explore potential enrollment in a pulmonary rehabilitation program to improve her respiratory function and enhance her quality of life.
Section 2
Change in Patient Status:
A few weeks into her treatment regimen, the patient begins to exhibit signs of worsening respiratory distress. Her oxygen saturation levels have dropped further to 85% on 3L/min of supplemental oxygen, and she now experiences increased dyspnea even at rest. Upon assessment, the nursing staff notes bilateral wheezing and diminished breath sounds in the right upper lobe, accompanied by the use of accessory muscles for breathing. The patient also reports a persistent, productive cough with rust-colored sputum, raising concerns about potential infection or progression of the disease.
Vital signs reveal a low-grade fever of 100.5°F, heart rate elevated at 112 beats per minute, and blood pressure slightly decreased at 100/65 mmHg. A repeat chest X-ray shows signs of a possible pleural effusion on the right side, while laboratory tests indicate a further drop in hemoglobin to 10.2 g/dL and a white blood cell count of 15,000/mm³, suggestive of an inflammatory process. The presence of pleural effusion and signs of infection necessitate immediate intervention, prompting the medical team to consider thoracentesis and initiate broad-spectrum antibiotics while awaiting culture results.
The healthcare team convenes to discuss the implications of these findings on the patient's treatment plan. Given her compromised respiratory status and the potential infectious process, adjustments to her current chemotherapy schedule are considered to mitigate further respiratory compromise. The patient's anxiety has escalated with these new developments, and she expresses feeling overwhelmed by the rapid changes in her condition. The nursing staff prioritizes supportive care, ensuring she has access to mental health resources, and emphasizes the importance of maintaining open communication to help her navigate these challenges. This holistic approach is essential to address both the physical and emotional aspects of her care as she continues her journey.
Section 3
A few days after initiating broad-spectrum antibiotics and performing a thoracentesis, the patient shows mixed responses to the interventions. While the procedure successfully alleviates some of the pressure on her right lung and slightly improves her oxygen saturation to 89% on 3L/min of supplemental oxygen, her overall respiratory status remains precarious. The repeat thoracentesis fluid analysis reveals exudative effusion, consistent with an inflammatory or infectious process, and cultures confirm the presence of a bacterial infection, prompting the team to refine her antibiotic regimen based on sensitivity results. Despite these efforts, the patient continues to experience significant dyspnea and fatigue, with labored breathing and audible wheezing persisting.
The nursing staff closely monitors her vital signs and notes persistent tachycardia with a heart rate of 110 beats per minute, while her blood pressure remains stable but on the lower side at 98/62 mmHg. Her temperature fluctuates, peaking at 101.2°F, indicating ongoing infection. Further laboratory tests show a slight improvement in white blood cell count, now at 13,500/mm³, yet her hemoglobin continues to decline, reaching 9.8 g/dL. This anemia, coupled with her respiratory challenges, necessitates a comprehensive review of her overall treatment strategy, including adjusting her chemotherapy schedule to allow for recovery.
The patient's psychological state remains fragile as she grapples with these setbacks. The healthcare team emphasizes the importance of multidisciplinary support, engaging palliative care specialists to optimize symptom management and provide additional emotional support. The focus shifts toward enhancing her quality of life and addressing her anxieties through counseling and relaxation techniques. The collaborative approach aims to empower the patient by involving her in decision-making processes, ensuring that her preferences and concerns are central to the evolving care plan. As the team evaluates her response to the modified treatment approach, they remain vigilant for any new complications that may arise, prepared to adapt swiftly to her changing needs.
Section 4
As the healthcare team continues to monitor the patient, they begin to notice a change in her status, prompting further assessment. Her respiratory distress seems to have worsened, with her oxygen saturation dropping to 85% on 3L/min of supplemental oxygen. This prompts an increase in oxygen delivery to 4L/min, yet her saturation struggles to maintain above 88%. Her respiratory rate has increased to 28 breaths per minute, and her wheezing has become more pronounced, suggesting the possibility of bronchospasm or worsening airway obstruction. Given these changes, the team considers the potential need for bronchodilators in her regimen to alleviate the wheezing and improve airflow.
Simultaneously, the patient's temperature spikes to 102°F, and her blood pressure shows a downward trend to 92/58 mmHg, raising concerns about potential sepsis or the progression of her infection. Her heart rate remains elevated at 115 beats per minute, indicative of her body's stress response. In light of these findings, the team performs additional blood cultures and adjusts her antibiotic coverage to include agents targeting resistant organisms, guided by infectious disease specialists.
The decline in her hemoglobin to 9.0 g/dL further complicates her condition, as anemia may exacerbate her dyspnea and fatigue. A transfusion is considered to improve her oxygen-carrying capacity, while the team explores possible causes of the anemia, such as bone marrow suppression from chemotherapy or ongoing blood loss. The patient's psychological state also requires attention, as the increased severity of her symptoms heightens her anxiety. Continuous engagement with palliative care and mental health specialists remains crucial, ensuring she feels supported through this challenging phase. The focus remains on stabilizing her condition, closely monitoring her response to the revised interventions, and adjusting her care plan as needed to enhance her comfort and quality of life.
Section 5
As the healthcare team continues to closely monitor the patient, they observe a further change in her status, indicating new complications. Despite the increase in supplemental oxygen to 4L/min, her oxygen saturation remains precariously low, fluctuating between 86% and 88%. Her respiratory distress is compounded by the development of accessory muscle use, indicating increased work of breathing. The wheezing, initially suggestive of bronchospasm, now appears to be accompanied by crackles upon auscultation of the lung fields, raising suspicions of fluid overload or possible pulmonary edema. This prompts the team to reassess her fluid balance, leading to a decision to restrict fluids and initiate diuretic therapy to mitigate potential fluid accumulation in the lungs.
Concurrently, the revised antibiotic regimen appears to be yielding positive results, as evidenced by a gradual reduction in her temperature to 100.5°F and stabilization of her blood pressure at 100/62 mmHg. However, the improvement in her infection markers is tempered by a concerning rise in her creatinine level to 1.8 mg/dL, suggesting acute kidney injury potentially secondary to sepsis or medication effects. This necessitates a careful review of her nephrotoxic medications and consideration of renal dose adjustments. The team collaborates with nephrology specialists to optimize her renal function while maintaining effective infection control.
The patient's anemia remains a pressing issue, with her hemoglobin level persistently low at 8.8 g/dL. After careful deliberation, a transfusion of packed red blood cells is administered, resulting in a modest improvement in her hemoglobin and a slight reduction in her heart rate to 105 beats per minute. This intervention provides some relief in her dyspnea and fatigue, yet underscores the need for ongoing investigation into the underlying cause of her anemia. Throughout these developments, the multidisciplinary team remains vigilant, adapting her care plan to address these evolving challenges, ensuring each decision is rooted in clinical reasoning and aimed at enhancing her overall stability and quality of life.