burns - Nursing Case Study

Pathophysiology

• Primary mechanism: Burns cause direct tissue damage leading to cell membrane disruption, which results in loss of cellular integrity and leakage of intracellular contents, triggering an inflammatory response.

• Secondary mechanism: The inflammatory response causes increased vascular permeability, leading to fluid shifts from the intravascular to the interstitial space, resulting in edema and hypovolemia, which can compromise perfusion to vital organs.

• Key complication: Hypovolemic shock can occur due to the significant fluid and electrolyte loss, necessitating prompt fluid resuscitation to maintain hemodynamic stability and prevent multi-organ failure.

Patient Profile

Demographics:

32-year-old female, restaurant chef

History:

• Key past medical history: Asthma, mild hypertension

• Current medications: Inhaler as needed (albuterol), Lisinopril 10 mg daily

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Burns on arms and hands with increasing pain

• Key symptoms: Blistering and swelling on affected areas, signs of infection (redness and warmth), difficulty in hand movement

• Vital signs: Temperature 101.4°F, Blood pressure 150/95 mmHg, Heart rate 110 bpm, Respiratory rate 22 breaths per minute

Section 1

As the medical team continues to assess the patient, new diagnostic results reveal a notable shift in her condition. Laboratory tests indicate an elevated white blood cell count of 15,000/mm³, suggesting a systemic inflammatory or infectious process. C-reactive protein levels are also elevated, corroborating the suspicion of an underlying infection. Blood cultures have been drawn to identify a potential bloodstream infection, and wound cultures are pending to determine the presence of specific bacterial pathogens. Given the patient's penicillin allergy, the healthcare team is considering alternative antibiotic regimens to manage the suspected infection effectively.

The patient's condition further evolves as her vital signs show persistent instability. Her blood pressure remains elevated at 148/92 mmHg, and her heart rate has increased to 115 bpm. The respiratory rate is now at 24 breaths per minute, indicating increased respiratory effort, possibly due to both pain and the systemic inflammatory response. Despite initial fluid resuscitation efforts, the patient exhibits signs of ongoing hypovolemia, including continued swelling in the affected areas and decreased urine output of less than 30 mL/hour. These findings suggest that fluid replacement may need to be adjusted to compensate for ongoing losses and to prevent further complications.

The clinical team must now prioritize balancing fluid resuscitation with the risk of exacerbating edema. Additionally, there is a need to initiate empirical antibiotic therapy to target the suspected infection while awaiting culture results. Continuous monitoring of the patient's hemodynamic status and renal function is essential to tailor interventions effectively. The development of respiratory distress, potentially linked to her history of asthma, calls for vigilance and possibly the use of bronchodilators to alleviate symptoms and prevent respiratory compromise.

Section 2

As the clinical team continues to monitor the patient, they note a change in her respiratory status, raising concerns about the potential for respiratory compromise. Despite receiving supplemental oxygen, the patient begins to exhibit increased work of breathing, characterized by the use of accessory muscles and audible wheezing upon auscultation. Her oxygen saturation has dropped to 90% on room air, prompting an escalation in oxygen support to maintain adequate levels. Given her history of asthma, the team decides to administer a nebulized bronchodilator, which results in modest improvement of her respiratory effort and wheezing, but her oxygen saturation remains borderline, necessitating close observation.

In response to the suspected infection, the medical team initiates empirical antibiotic therapy with a combination of clindamycin and levofloxacin, considering her penicillin allergy. These antibiotics are chosen for their broad-spectrum coverage and efficacy against common pathogens associated with burn wound infections. Meanwhile, fluid resuscitation is adjusted based on frequent assessments of her hemodynamic status. The team opts for a cautious increase in intravenous fluids, closely monitoring for signs of fluid overload, while also aiming to improve her urine output, which has shown slight improvement to 35 mL/hour.

Despite these interventions, the patient begins to exhibit signs of altered mental status, becoming increasingly lethargic and less responsive to verbal stimuli. This change, coupled with her other symptoms, heightens the concern for sepsis and potential multiorgan dysfunction. The nursing team prioritizes frequent neurological assessments and collaborates with the interdisciplinary team to reevaluate her treatment plan. The focus now shifts to optimizing her hemodynamic support, fine-tuning antibiotic therapy based on culture results, and addressing her respiratory needs to prevent further decline.

Section 3

The patient's condition continues to evolve, and the team notes a significant change in her status when her vital signs are reassessed. Her heart rate has increased to 115 beats per minute, her blood pressure has dropped to 88/54 mmHg, and her respiratory rate has risen to 28 breaths per minute. These findings, combined with her persistent lethargy and decreased oxygen saturation, suggest worsening respiratory and hemodynamic instability. A repeat arterial blood gas analysis shows a pH of 7.33, PaCO2 of 48 mmHg, and PaO2 of 58 mmHg on increased oxygen support, indicating a state of acute respiratory acidosis and hypoxemia. Additionally, laboratory results reveal an elevated white blood cell count of 18,500/mm³ and a serum lactate level of 4.2 mmol/L, reinforcing the suspicion of sepsis and potential systemic inflammatory response syndrome (SIRS).

The team responds by implementing a more aggressive approach to her management. Given the potential for evolving sepsis and associated multiorgan dysfunction, the decision is made to transfer the patient to the intensive care unit for closer monitoring and advanced support. The patient's fluid resuscitation strategy is revised to include the administration of vasopressors to stabilize her blood pressure, alongside continued careful fluid management to avoid exacerbating her respiratory status. In tandem with these efforts, the team initiates a high-flow nasal cannula to improve her oxygenation and reduce respiratory distress. Meanwhile, infectious disease specialists review the antibiotic regimen, adjusting based on preliminary culture results that indicate sensitivity to the current therapy.

As the patient is stabilized and closely monitored in the ICU, the nursing team conducts frequent assessments, noting any subtle changes in her neurological status and respiratory effort. The interdisciplinary team collaborates to refine her treatment plan further, ensuring that all clinical decisions are informed by the latest diagnostic data and her evolving clinical picture. The focus remains on preventing further complications, optimizing her hemodynamic and respiratory support, and tailoring her antimicrobial therapy to address the underlying infection effectively. This comprehensive approach aims to halt the progression of sepsis and promote recovery, setting the stage for the next critical phase of her care.

Section 4

As the patient settles into the ICU, the team maintains a vigilant watch over her changing condition. Despite the implementation of high-flow nasal cannula and vasopressors, her oxygen saturation remains a concern, fluctuating between 86% and 90%. Her heart rate is persistently elevated at 120 beats per minute, and blood pressure stabilizes slightly at 92/58 mmHg. However, her respiratory rate remains elevated at 30 breaths per minute, indicating ongoing respiratory distress. A new chest X-ray ordered to further investigate her respiratory status reveals the development of bilateral infiltrates, suggestive of acute respiratory distress syndrome (ARDS), a complication likely related to her burn injuries and suspected sepsis.

In light of these findings, the team discusses the possibility of escalating her respiratory support. There is consensus on the need to intubate the patient and initiate mechanical ventilation to improve oxygenation and ease the work of breathing. Meanwhile, repeat laboratory tests show a further increase in serum lactate to 5.0 mmol/L and a persistent elevation in white blood cell count at 20,000/mm³, reinforcing the ongoing inflammatory response. Blood cultures confirm the presence of a Gram-negative organism, necessitating a modification of her antibiotic regimen to target this pathogen more effectively.

These developments prompt a recalibration of the treatment strategy, with the interdisciplinary team coordinating efforts to manage the emerging ARDS while continuing aggressive treatment of the sepsis. The focus shifts to optimizing ventilator settings to prevent further lung injury and ensuring precise titration of vasopressors and fluids to maintain adequate perfusion without exacerbating pulmonary edema. The nursing team plays a crucial role in monitoring the patient’s response to these interventions, paying close attention to changes in her neurological status, urine output, and skin integrity, all of which are critical indicators of her overall condition and response to treatment. This concerted effort aims to stabilize her condition, prevent further complications, and guide her towards recovery from this critical phase of her illness.

Section 5

As the patient progresses through her treatment in the ICU, the team continues to monitor her closely for any changes in status or new complications. Following the initiation of mechanical ventilation, the patient's oxygen saturation shows a modest improvement, now consistently ranging between 92% and 94%. However, her respiratory rate remains elevated at 28 breaths per minute, and her work of breathing appears less labored. Despite these improvements, the patient's heart rate remains high at 118 beats per minute, indicating persistent stress on her system. Blood pressure readings hold steady at 94/60 mmHg, suggesting a delicate balance in her hemodynamic status.

New laboratory results return, revealing a concerning renal function trend. The patient's serum creatinine has increased to 2.4 mg/dL from a baseline of 1.1 mg/dL, and her blood urea nitrogen (BUN) levels have risen to 34 mg/dL. These findings, coupled with a decrease in urine output to 20 mL/hour, signal the development of acute kidney injury (AKI), likely secondary to the combined effects of sepsis and possible nephrotoxic insult from antibiotics and vasopressor use. The interdisciplinary team recognizes the need to reassess her fluid management strategy, ensuring adequate renal perfusion while avoiding fluid overload that could worsen her ARDS.

The nursing team plays a pivotal role in implementing these adjustments, focusing on precise fluid balance and vigilant monitoring for signs of fluid overload or further renal compromise. Additionally, nephrology is consulted to evaluate the necessity of renal replacement therapy should the patient's renal function continue to decline. These developments challenge the team to refine the balance between managing her respiratory status, hemodynamics, and renal function. As the team navigates these complexities, the goal remains to stabilize the patient, mitigate further complications, and support her progression toward recovery.