hypertension - Nursing Case Study

Pathophysiology

• Primary mechanism: Increased peripheral resistance - Hypertension often arises from the narrowing of blood vessels, which increases the resistance against blood flow. This is primarily due to the dysfunction of the endothelium (the inner lining of blood vessels) and overactivity of the renin-angiotensin-aldosterone system (RAAS), leading to vasoconstriction.

• Secondary mechanism: Increased cardiac output - An elevated blood volume, often due to sodium retention influenced by hormonal imbalances like excess aldosterone, can increase cardiac output. This heightened volume exerts additional pressure on vessel walls.

• Key complication: Target organ damage - Constant high pressure can damage vital organs such as the heart, kidneys, and brain, leading to conditions like heart failure, renal impairment, and stroke, emphasizing the importance of blood pressure management in clinical practice.

Patient Profile

Demographics:

56-year-old female, office manager

History:

• Key past medical history: Hypertension diagnosed 5 years ago, type 2 diabetes, hyperlipidemia

• Current medications: Lisinopril, Metformin, Atorvastatin

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Persistent headaches and dizziness

• Key symptoms: Fatigue, blurred vision, occasional chest pain

• Vital signs: Blood pressure 160/100 mmHg, heart rate 88 bpm, respiratory rate 20 breaths per minute, temperature 98.6°F

Section 1

New Diagnostic Results:

Following the initial assessment, the healthcare team decided to conduct a series of diagnostic tests to better understand the patient's current condition and the extent of any complications. Laboratory tests revealed elevated serum creatinine at 1.8 mg/dL (normal range: 0.6-1.2 mg/dL) and an increased blood urea nitrogen (BUN) at 28 mg/dL (normal range: 7-20 mg/dL), indicating potential renal impairment. Additionally, the patient's lipid profile showed total cholesterol of 245 mg/dL, HDL of 40 mg/dL, LDL of 160 mg/dL, and triglycerides at 210 mg/dL, pointing towards poorly controlled hyperlipidemia.

An echocardiogram was performed to evaluate the heart's structure and function, revealing left ventricular hypertrophy, which is a common consequence of prolonged hypertension as the heart works harder to pump blood against elevated resistance. The electrocardiogram (ECG) showed signs of left atrial enlargement and occasional premature ventricular contractions. These findings suggest that the heart is under significant strain, potentially leading to more serious cardiac issues if not addressed.

The results prompted an immediate review of the patient's current medication regimen, considering the need for more aggressive management of hypertension and renal protection. The healthcare team discussed the potential addition of a calcium channel blocker or a thiazide diuretic to help lower blood pressure more effectively. Furthermore, the possibility of starting an SGLT2 inhibitor was considered to address both the patient's diabetes and renal concerns, as these medications have shown benefits in reducing cardiovascular and renal events. The patient was advised on lifestyle modifications, including dietary changes and increased physical activity, to further aid in controlling her blood pressure and lipid levels. These steps are crucial in preventing further target organ damage and stabilizing her condition.

Section 2

Change in Patient Status:

Several weeks after the adjustments to the medication regimen and implementation of lifestyle modifications, the patient returned for a follow-up visit. She reported feeling more fatigued than usual and experiencing occasional dizziness, particularly when standing up quickly. A repeat set of vital signs revealed a blood pressure of 145/88 mmHg, slightly improved but still above the target range. Her heart rate was measured at 92 beats per minute, and her respiratory rate was normal at 16 breaths per minute. Notably, the patient had gained 3 pounds since her last visit, raising concerns about fluid retention potentially related to the new medications or decreased physical activity.

The laboratory tests showed that serum creatinine had further increased to 2.0 mg/dL, and BUN was now at 32 mg/dL, indicating worsening renal function despite efforts to manage her condition. Her lipid profile remained largely unchanged, with a total cholesterol of 240 mg/dL and LDL at 155 mg/dL, suggesting that lifestyle modifications alone were insufficient to significantly impact her lipid levels.

These findings prompted the healthcare team to reassess the patient's current treatment plan. The persistent hypertension and renal function deterioration required a more nuanced approach. The team considered the potential addition of an ACE inhibitor or ARB to provide renal protection and address the hypertension more effectively. They also discussed intensifying lipid-lowering therapy, potentially introducing a statin with a higher potency. The patient was counseled on the importance of adhering to dietary recommendations and increasing her physical activity, emphasizing these interventions' role in managing her overall cardiovascular risk profile. This change in status signaled the need for ongoing monitoring and a possible reevaluation of her therapeutic goals to prevent further complications.

Section 3

In response to the patient's ongoing symptoms and laboratory findings, the healthcare team decided to implement changes to her medication regimen, including the introduction of an ACE inhibitor to provide renal protection and better control her hypertension. A more potent statin was also prescribed to address her elevated lipid levels. Over the following weeks, the patient adhered to the new medication plan and continued her lifestyle modifications. However, during a subsequent follow-up visit, she reported experiencing a persistent dry cough and noted that her fatigue had intensified, with episodes of dizziness occurring more frequently. Her vital signs revealed a blood pressure of 138/85 mmHg, showing some improvement, but her heart rate had increased to 98 beats per minute, and she had gained another 2 pounds, raising further concerns about fluid retention.

A new set of laboratory tests showed her serum creatinine had stabilized at 2.0 mg/dL, but her BUN increased slightly to 35 mg/dL. Her liver function tests were within normal limits, ruling out hepatotoxicity from the statin. However, her potassium level was noted to be slightly elevated at 5.5 mEq/L, suggesting a potential side effect of the ACE inhibitor. These findings prompted the healthcare team to consider the possibility of hyperkalemia as a complication and evaluate the patient's medication regimen for necessary adjustments. The team deliberated on whether to switch to an ARB to alleviate the cough and manage potassium levels while continuing to monitor her renal function closely.

The patient's change in status required careful consideration of the balance between managing her hypertension, protecting her renal function, and minimizing adverse effects from medications. This situation underscored the need for ongoing clinical reasoning and vigilant monitoring to prevent further complications. The healthcare team planned to reassess her therapeutic goals and consider additional interventions, such as dietary potassium restrictions and possibly diuretic therapy, to address fluid retention and hyperkalemia. This approach aimed to optimize her treatment plan and improve her overall quality of life while mitigating the risk of more severe complications.

Section 4

The healthcare team decided to switch the patient from the ACE inhibitor to an Angiotensin II Receptor Blocker (ARB) to address her persistent dry cough while minimizing the risk of hyperkalemia. Despite this change, during her next follow-up visit, the patient reported experiencing increased swelling in her lower extremities and noted that her episodes of dizziness had worsened, now accompanied by occasional palpitations. On examination, her blood pressure was 140/88 mmHg, and her heart rate remained elevated at 102 beats per minute. Peripheral edema was noted, along with mild jugular venous distension, raising concerns about worsening fluid retention and possible early signs of heart failure.

A repeat set of laboratory tests revealed her serum potassium level had decreased slightly to 5.3 mEq/L, yet her BUN increased further to 40 mg/dL, and her serum creatinine rose to 2.2 mg/dL, indicating a decline in renal function. The healthcare team was also alarmed by a new finding: a slightly elevated BNP level at 120 pg/mL, suggesting increased cardiac strain. Given these developments, the team considered initiating low-dose diuretic therapy to address fluid overload and prevent further renal compromise. Additionally, an echocardiogram was ordered to assess cardiac function, given the patient's symptoms and lab findings.

These changes in the patient's status necessitated a re-evaluation of her treatment goals, with a focus on carefully balancing her cardiovascular and renal needs. The healthcare team emphasized the importance of reducing dietary sodium and monitoring fluid intake, alongside the potential introduction of diuretic therapy. They also planned for more frequent follow-ups to closely monitor her response and adjust her treatment plan as needed to prevent the progression of heart failure and further renal impairment. This approach was intended to improve her symptoms and stabilize her condition, underscoring the importance of continuous clinical reasoning and vigilance in managing complex cases like hers.

Section 5

A week after initiating low-dose diuretic therapy, the patient returned for a follow-up visit. She reported a noticeable reduction in the swelling of her lower extremities and a modest improvement in her breathing, particularly when lying down. However, she continued to experience episodes of dizziness and palpitations, which were now accompanied by occasional fatigue. On examination, her blood pressure had improved slightly to 132/84 mmHg, but her heart rate remained elevated at 98 beats per minute. Auscultation of her heart revealed a new finding: a soft S3 gallop, which raised concerns about the possibility of diastolic dysfunction or early heart failure.

A repeat set of laboratory tests showed that her serum potassium level had stabilized at 5.0 mEq/L, but her renal function remained compromised, with a serum creatinine of 2.3 mg/dL and a BUN of 42 mg/dL. The slight increase in BNP to 150 pg/mL suggested persistent cardiac strain despite the diuretic therapy. The echocardiogram revealed mild left ventricular hypertrophy with preserved ejection fraction, aligning with the suspicion of diastolic dysfunction. The team interpreted these findings as indicative of persistent fluid overload and possible early heart failure, despite some symptomatic relief.

Given the new findings and the persistence of her symptoms, the healthcare team discussed further adjustments to her treatment plan. They considered the addition of a beta-blocker to manage her elevated heart rate and provide additional cardiac support, while continuing to emphasize dietary modifications and fluid management. The team planned to monitor her closely through frequent follow-ups and laboratory testing to ensure that her condition stabilized without further compromising her renal function. This careful balancing act highlighted the importance of continuous reassessment and clinical reasoning in managing her complex health needs.