Diabetes Mellitus - Nursing Case Study
Pathophysiology
• Primary mechanism: In Type 1 Diabetes Mellitus, autoimmune destruction of pancreatic beta cells leads to an absolute insulin deficiency, resulting in hyperglycemia as glucose uptake by cells is impaired.
• Secondary mechanism: In Type 2 Diabetes Mellitus, insulin resistance occurs, where cells fail to respond appropriately to insulin, coupled with an eventual decline in insulin production, further exacerbating hyperglycemia.
• Key complication: Chronic hyperglycemia can lead to microvascular complications such as retinopathy, nephropathy, and neuropathy, emphasizing the importance of blood glucose control to prevent long-term damage.
Patient Profile
Demographics:
55-year-old male, office manager
History:
• Type 2 Diabetes Mellitus diagnosed 8 years ago, hypertension, hyperlipidemia
• Metformin 1000 mg twice daily, Lisinopril 20 mg once daily, Atorvastatin 40 mg once daily
• No known drug allergies
Current Presentation:
• Chief complaint: increasing fatigue and numbness in feet
• Key symptoms: frequent urination, blurred vision, tingling sensation in extremities, occasional dizziness
• Vital signs: Blood pressure 150/95 mmHg, heart rate 92 bpm, respiratory rate 18 breaths per minute, temperature 98.6°F, blood glucose level 190 mg/dL fasting
Section 1
New Diagnostic Results:
The patient's recent laboratory results provide greater insight into the progression of his condition. His Hemoglobin A1c (HbA1c) level has risen to 9.0%, indicating poor long-term glycemic control over the past three months. Additionally, a comprehensive metabolic panel reveals elevated creatinine levels at 1.5 mg/dL, suggesting potential renal impairment, and microalbuminuria is noted with a urine albumin-to-creatinine ratio of 35 mg/g, further pointing to early nephropathy. Lipid profile results show an LDL cholesterol level of 160 mg/dL, indicating suboptimal control of hyperlipidemia despite ongoing atorvastatin therapy.
These findings highlight the need for a multifaceted approach to manage not only his diabetes but also his cardiovascular risk factors and emerging renal issues. The elevated HbA1c suggests that adjustments to his diabetes management plan are necessary, potentially involving the introduction of a GLP-1 receptor agonist or SGLT2 inhibitor, which can provide both glycemic control and renal protection. The rising creatinine and microalbuminuria emphasize the need for close monitoring of renal function and possibly adjusting his antihypertensive regimen, considering the addition of an angiotensin receptor blocker (ARB) to further protect his renal health.
As the healthcare team evaluates these results, they will need to consider the patient's symptomatology, particularly his increasing fatigue and neuropathic symptoms, which might be exacerbated by poor glycemic control and warrant further investigation. The team should also prioritize patient education to improve adherence to lifestyle modifications, which are crucial for managing his condition and preventing further complications. This comprehensive approach aims to stabilize the patient's condition and prevent the progression of diabetic complications, setting the stage for the next steps in his care journey.
Section 2
Change in Patient Status:
In the weeks following the adjustments in the patient's management plan, including the introduction of a GLP-1 receptor agonist and an angiotensin receptor blocker (ARB), the patient returns for a follow-up appointment. During the assessment, the nurse notes that the patient's blood pressure has improved, now reading 130/80 mmHg, indicating a positive response to the ARB. However, the patient reports persistent fatigue and new-onset intermittent dizziness, which has been occurring more frequently. The nurse observes that the patient appears slightly pale and notes mild orthostatic hypotension, with a drop of 15 mmHg in systolic blood pressure upon standing.
Laboratory workup reveals a notable decrease in estimated glomerular filtration rate (eGFR) to 55 mL/min/1.73 m², suggesting a progression of renal impairment. Additionally, the patient's hemoglobin level is found to be 11.2 g/dL, indicating mild anemia, which could be contributing to his fatigue and dizziness. The combination of these findings necessitates a re-evaluation of the patient's current medication regimen and dietary intake, particularly ensuring adequate iron and vitamin B12 levels to address the anemia. The healthcare team considers the possibility of adjusting the dosages of his medications and advising on dietary changes to better support renal function and overall health.
The patient's ongoing neuropathic symptoms, including tingling and numbness in his feet, are also discussed. The team considers adding a medication such as pregabalin to help manage these symptoms, while reinforcing the importance of glycemic control to prevent further nerve damage. The nurse emphasizes the critical role of patient education in lifestyle modifications, focusing on dietary adjustments, regular physical activity, and adherence to the medication plan to optimize outcomes. This comprehensive follow-up plan aims to address the current complications and prevent further deterioration, setting a course for the next stage of the patient's diabetes management journey.
Section 3
In the subsequent weeks, the patient returns for another follow-up evaluation, presenting with further changes in his health status. His blood pressure remains stable at 132/82 mmHg, indicating continued efficacy of the angiotensin receptor blocker. However, the patient reports that his dizziness has become more frequent and is now accompanied by episodes of shortness of breath, particularly during mild exertion. Upon examination, the nurse notes increased pallor and mild tachycardia, with a heart rate of 102 beats per minute. Further laboratory tests reveal a decrease in hemoglobin to 10.5 g/dL, exacerbating his anemia. Additionally, his eGFR has declined slightly to 50 mL/min/1.73 m², raising concerns about worsening renal function.
The healthcare team reviews these findings and decides to prioritize addressing the anemia and potential underlying causes. They consider the possibility of iron-deficiency anemia and initiate iron supplementation while planning to assess vitamin B12 and folate levels. The team also expresses concern about the progression of renal impairment and discusses the potential need for nephrology referral if further decline is observed. Alongside these adjustments, the patient is advised to monitor his symptoms closely, particularly any changes in his shortness of breath or dizziness, which could indicate further complications.
As part of a holistic approach, the nurse reinforces education on the importance of dietary modifications, emphasizing foods rich in iron and essential vitamins, while also considering the renal-friendly aspect to avoid aggravating the kidney condition. The patient is encouraged to engage in gentle, regular physical activity tailored to his tolerance levels to improve circulation and overall well-being. This comprehensive plan aims to stabilize the patient's current health concerns, mitigate anemia symptoms, and prevent further renal deterioration, setting the groundwork for ongoing management and monitoring in the next phase of his diabetes care journey.
Section 4
In the following weeks, the patient returns for another follow-up appointment, reporting some improvement in energy levels but persistent episodes of dizziness and shortness of breath. He has been compliant with the iron supplementation regimen, and dietary modifications have been incorporated into his daily routine. Upon examination, his vital signs reveal a stable blood pressure of 130/80 mmHg, but his heart rate remains elevated at 98 beats per minute. Although the patient appears less pale, the nurse notes a slight decrease in peripheral perfusion, with capillary refill time approaching the upper limit of normal.
New laboratory results indicate that his hemoglobin has improved slightly to 11.0 g/dL, suggesting a positive response to the iron supplementation. However, the vitamin B12 level is found to be borderline low, prompting further evaluation for potential mixed anemia. Meanwhile, the patient’s renal function remains a concern, as his eGFR has declined further to 48 mL/min/1.73 m². This suggests a gradual progression of his diabetic nephropathy, warranting closer monitoring and consideration of a nephrology referral to prevent further renal compromise.
The healthcare team discusses these findings, emphasizing the need for a balanced approach to address both the anemia and renal function. They consider initiating vitamin B12 supplementation while continuing to monitor renal parameters closely. The patient is advised to maintain hydration and avoid nephrotoxic medications, and he is encouraged to report any changes in urinary output or new symptoms promptly. This updated plan aims to stabilize the patient's condition, mitigate potential complications, and ensure a proactive approach in managing his diabetes-related health challenges.
Section 5
Several weeks later, the patient returns for another follow-up appointment. This time, he reports increasing fatigue, occasional chest discomfort, and swelling in his lower extremities. He has adhered to the vitamin B12 supplementation and continues to follow dietary recommendations. Upon examination, the nurse notes that his blood pressure has risen slightly to 140/85 mmHg, and his heart rate remains elevated at 100 beats per minute. There is noticeable bilateral pitting edema in his ankles, and the patient exhibits mild jugular venous distention.
New laboratory results reveal a further decline in renal function, with an eGFR of 44 mL/min/1.73 m², indicating progressive diabetic nephropathy. His serum potassium level is now elevated at 5.6 mmol/L, raising concerns about potential hyperkalemia, a common complication in chronic kidney disease. Additionally, a follow-up complete blood count shows that while his hemoglobin level has stabilized at 11.2 g/dL, his mean corpuscular volume (MCV) remains low, suggesting the continued presence of microcytic anemia.
The healthcare team recognizes the complexity of the patient's case, necessitating a multidisciplinary approach. A nephrology referral is expedited to address the decline in renal function and manage electrolyte imbalances effectively. The patient's antihypertensive regimen is reviewed, with consideration given to medications that could minimize further renal damage and control blood pressure. The team emphasizes the importance of monitoring his blood pressure and potassium levels closely, alongside dietary adjustments to manage fluid retention and electrolyte balance. This carefully coordinated plan aims to prevent further complications and stabilize the patient's condition as he navigates the challenges of his diabetes management.