diabetes - Nursing Case Study

Pathophysiology

• Primary mechanism: In diabetes, insulin production is impaired (Type 1) or cells become resistant to insulin (Type 2), leading to inadequate glucose uptake by cells, resulting in elevated blood glucose levels.

• Secondary mechanism: Chronic high blood sugar causes damage to blood vessels and nerves, leading to complications such as neuropathy, retinopathy, and nephropathy as glucose interacts with proteins and lipids, forming advanced glycation end-products (AGEs).

• Key complication: Persistent hyperglycemia can result in cardiovascular disease due to atherosclerosis from endothelial damage, increasing the risk of heart attacks and strokes.

Patient Profile

Demographics:

58-year-old male, accountant

History:

• Key past medical history: Type 2 diabetes diagnosed 8 years ago, hypertension, high cholesterol

• Current medications: Metformin, Lisinopril, Atorvastatin, Aspirin

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Increasing fatigue and occasional blurred vision

• Key symptoms: Numbness and tingling in feet, frequent urination, unintentional weight loss

• Vital signs: Blood pressure 145/90 mmHg, heart rate 88 bpm, respiratory rate 18 breaths per minute, temperature 98.6°F, random blood glucose 220 mg/dL

Section 1

New Diagnostic Results:

Following the initial assessment, the healthcare team decided to conduct a series of diagnostic tests to better understand the patient's condition and the extent of his diabetes-related complications. A comprehensive metabolic panel revealed an elevated HbA1c level of 9.2%, indicating poor long-term glucose control over the past three months. Additionally, a lipid panel showed elevated LDL cholesterol levels at 160 mg/dL, alongside low HDL cholesterol at 35 mg/dL, further confirming the patient's increased cardiovascular risk profile.

A urinalysis was performed to assess kidney function, revealing microalbuminuria with an albumin-to-creatinine ratio of 35 mg/g, suggesting early signs of diabetic nephropathy. In light of the patient's symptoms of numbness and tingling in the feet, a nerve conduction study was conducted, which confirmed peripheral neuropathy affecting both sensory and motor nerves in the lower extremities. An ophthalmologic examination was also ordered due to the patient's complaints of blurred vision, which identified early-stage diabetic retinopathy with mild non-proliferative changes.

These diagnostic results highlight the progression of diabetes-related complications, necessitating a multi-disciplinary approach to manage and mitigate further damage. The healthcare team must now consider adjustments to the patient's medication regimen, lifestyle interventions, and potentially more aggressive cardiovascular risk management strategies. This will involve collaborative discussions with the patient to address these findings, explore treatment options, and emphasize the importance of adherence to prescribed therapies and lifestyle modifications to prevent further complications.

Section 2

After reviewing the new diagnostic results, the healthcare team initiated a multi-pronged intervention strategy to address the patient's diabetes-related complications. The primary focus was on improving glycemic control and reducing cardiovascular risk. The patient's medication regimen was adjusted to include a sodium-glucose co-transporter-2 (SGLT2) inhibitor, which not only helps lower blood glucose levels but also offers renal protective benefits. Additionally, a statin was prescribed to manage the elevated LDL cholesterol, aiming to lower it to less than 100 mg/dL to reduce cardiovascular risk. The patient was encouraged to follow a heart-healthy diet, rich in omega-3 fatty acids, and engage in regular physical activity, emphasizing activities that would be gentle on his peripheral neuropathy.

During a follow-up appointment four weeks later, the patient reported partial improvement in his energy levels and a slight decrease in the numbness in his feet, suggesting a positive response to the interventions. However, the patient also mentioned experiencing occasional dizziness and mild hypotension, with blood pressure readings sometimes dipping to 100/60 mmHg. This prompted the healthcare team to review the patient's medication dosages, especially considering the potential impact of the SGLT2 inhibitor on blood pressure. The team decided to monitor the patient's blood pressure closely and advised him to stay hydrated and rise slowly from sitting or lying positions to reduce the risk of dizziness and falls.

As the patient continues to adapt to these changes, the healthcare team remains vigilant for any new complications. Close monitoring of kidney function and regular ophthalmologic evaluations are planned to detect any progression in diabetic nephropathy and retinopathy. The patient was educated on recognizing signs of hypoglycemia and the importance of adhering to his modified treatment plan, reinforcing the collaborative effort needed to manage his diabetes effectively. The focus remains on preventing further complications through proactive management and patient engagement in his own care.

Section 3

New Complications

Two months after the initial intervention adjustments, the patient returned for a routine follow-up visit. Although his glycemic control had improved, with HbA1c levels dropping from 8.5% to 7.2%, the patient reported new symptoms that warranted further investigation. He described experiencing shortness of breath during mild exertion and swelling in his lower extremities, particularly around the ankles. Upon physical examination, pitting edema was noted bilaterally, and lung auscultation revealed bilateral crackles at the lung bases, suggesting fluid retention. These findings raised concerns about the development of heart failure, a potential complication given his diabetic status and cardiovascular risk factors.

The healthcare team promptly ordered a series of diagnostic tests to evaluate the patient's cardiac function. An echocardiogram revealed a reduced ejection fraction of 40%, indicative of systolic heart failure. Additionally, laboratory results showed elevated B-type natriuretic peptide (BNP) levels of 650 pg/mL, further supporting the diagnosis. The patient's kidney function remained stable, with an estimated glomerular filtration rate (eGFR) of 65 mL/min/1.73m², but the team recognized the need for careful management to balance heart failure treatment without compromising renal health.

In response to these new complications, the healthcare team implemented a revised treatment strategy. A low-dose beta-blocker and an angiotensin-converting enzyme (ACE) inhibitor were added to the patient's regimen to improve cardiac output and reduce fluid overload. The importance of strict dietary sodium restriction was emphasized, and the patient was advised to monitor his daily weight to detect any sudden changes. Education focused on understanding the signs and symptoms of worsening heart failure and the necessity of adhering to the updated treatment plan. The patient was scheduled for more frequent follow-up visits to closely monitor his cardiac status and adjust treatment as necessary, ensuring a comprehensive approach to managing his diabetes and associated complications.

Section 4

Response to Interventions

Two weeks following the initiation of the revised treatment strategy, the patient returned for a scheduled follow-up visit. The healthcare team conducted a comprehensive assessment to evaluate the effectiveness of the interventions. The patient reported a noticeable improvement in his symptoms. He mentioned that the shortness of breath during mild exertion had significantly decreased, allowing him to perform daily activities with greater ease. Furthermore, he noticed a reduction in the swelling of his lower extremities, attributing this improvement to his adherence to the low-sodium diet and the daily weight monitoring protocol.

Upon physical examination, the pitting edema in the patient's ankles had diminished, and lung auscultation revealed a reduction in crackles, indicating decreased fluid retention. Vital signs were stable, with a blood pressure reading of 120/75 mmHg and a heart rate of 70 beats per minute, suggesting a positive response to the beta-blocker and ACE inhibitor therapy. Follow-up laboratory tests showed a slight decrease in BNP levels to 500 pg/mL, reflecting an improvement in cardiac function.

Despite these positive changes, the healthcare team remained vigilant in monitoring for potential side effects of the new medications, such as hypotension or renal impairment. They emphasized the importance of ongoing communication regarding any new symptoms or concerns. The patient expressed confidence in managing his condition, supported by the education and resources provided. The team scheduled another follow-up visit in four weeks to reassess the patient’s progress and make any necessary adjustments to his treatment plan, ensuring continued management of his diabetes and heart failure.

Section 5

At the next follow-up visit, four weeks later, the patient presented with new symptoms that warranted further investigation. He reported experiencing increased fatigue and occasional dizziness upon standing, which he had not noticed previously. Additionally, he mentioned frequent urination and persistent thirst, which raised concerns for the healthcare team about potential complications related to his diabetes management. Upon examination, his vital signs revealed a new onset of orthostatic hypotension, with a supine blood pressure of 115/70 mmHg dropping to 90/60 mmHg upon standing, accompanied by a slight increase in heart rate to 85 beats per minute.

Given these new symptoms, the healthcare team ordered a comprehensive metabolic panel and hemoglobin A1c test to evaluate his glycemic control and renal function. The results indicated a mild deterioration in renal function, with a creatinine level of 1.5 mg/dL, up from 1.2 mg/dL at the last visit, and an estimated glomerular filtration rate (eGFR) of 55 mL/min/1.73 m², suggesting a decline from his baseline. His hemoglobin A1c had increased to 8.5%, indicating suboptimal glucose control despite the current regimen.

These findings prompted a thorough review of the patient's medications and lifestyle factors. The team considered the possibility that the combination of his ACE inhibitor and diuretic therapy might be contributing to the orthostatic hypotension and renal impairment, necessitating a reassessment of his antihypertensive regimen. Additionally, the increase in hemoglobin A1c suggested that further adjustments were needed in his diabetic management plan, possibly including modifications to his diet, exercise routine, or medication. The team recommended close monitoring and scheduled more frequent follow-ups to address these evolving complications, ensuring a comprehensive approach to managing both his diabetes and cardiovascular health.