diverticulitis - Nursing Case Study

Pathophysiology

• Primary mechanism: Diverticulitis primarily results from the inflammation of diverticula, which are small pouches that form in weakened areas of the colon wall, often due to increased intraluminal pressure and lack of dietary fiber. This inflammation can lead to localized tissue damage and infection within the colon.

• Secondary mechanism: Obstruction of the diverticula by fecal matter or undigested food particles can exacerbate inflammation, promoting bacterial overgrowth and increasing the risk of perforation, which may lead to localized peritonitis or abscess formation.

• Key complication: Untreated diverticulitis can progress to bowel perforation, leading to peritonitis, sepsis, or fistula formation, which are serious complications requiring immediate medical intervention to prevent widespread infection and systemic complications.

Patient Profile

Demographics:

54-year-old male, construction worker

History:

• Key past medical history: History of diverticulosis diagnosed 2 years ago, hypertension

• Current medications: Lisinopril 10 mg daily, Metamucil as needed

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Abdominal pain and fever

• Key symptoms: Left lower quadrant pain, fever, nausea, intermittent diarrhea, mild bloating

• Vital signs: Temperature 101.3°F, Blood Pressure 148/92 mmHg, Heart Rate 104 bpm, Respiratory Rate 20 breaths per minute

Section 1

As the healthcare team conducts an initial assessment, the patient's condition raises concerns for potential complications of diverticulitis. Upon examination, the patient's abdomen is tender to palpation, particularly in the left lower quadrant, with guarding and rebound tenderness present. These findings suggest localized peritonitis, possibly indicating a micro-perforation of the bowel. The patient's white blood cell count is elevated at 15,000/mm³, indicating an active infection and inflammatory response. His C-reactive protein level is also significantly increased, further supporting the inflammatory process.

Imaging studies, including a CT scan of the abdomen and pelvis with contrast, reveal thickening of the sigmoid colon with pericolic fat stranding, consistent with acute diverticulitis. Notably, there is evidence of a small abscess formation adjacent to the affected diverticula, measuring about 2 cm in diameter. This finding confirms a complication requiring intervention to prevent further deterioration. Given the patient's current hemodynamic status and evidence of localized infection, the healthcare team considers initiating targeted antibiotic therapy and consults with a surgical team to evaluate the need for percutaneous drainage of the abscess.

The patient's condition prompts the need for close monitoring and re-evaluation. The decision-making process involves weighing the benefits and risks of conservative management versus surgical intervention. The healthcare team also considers adjusting the patient's current medications, such as withholding the Metamucil to avoid exacerbating the condition, and ensuring that his hypertension is adequately managed to support overall stability. This scenario illustrates the importance of timely recognition and appropriate management of complications to prevent progression to more severe outcomes. As the team addresses these complications, they prepare for possible changes in treatment strategy based on the patient's response to initial interventions.

Section 2

As the healthcare team continues to monitor the patient, they notice a change in his status that warrants further investigation. Over the course of the next 24 hours, the patient begins to exhibit signs of increasing abdominal pain and distension, and his vital signs reveal a concerning trend. His temperature has risen to 38.9°C (102°F), and his heart rate has increased to 110 beats per minute, suggesting a possible worsening of the infection or development of sepsis. Blood pressure remains stable at 130/80 mmHg, but the patient's respiratory rate has increased to 24 breaths per minute, indicating potential respiratory compensation for metabolic acidosis.

In response to these changes, the healthcare team orders additional laboratory tests and reassesses the patient's fluid and electrolyte status. Repeat blood work shows a further increase in white blood cell count to 18,000/mm³ and a notable drop in hemoglobin to 10.5 g/dL, raising concerns about potential bleeding or further complications within the abdomen. Electrolyte analysis reveals slight hyponatremia with a sodium level of 133 mmol/L, likely due to fluid shifts or increased inflammation. Given these findings, the team hypothesizes that the abscess may have increased in size or that a new micro-perforation has occurred, necessitating a more aggressive treatment approach.

The surgical team is promptly re-consulted, and a repeat CT scan is ordered to assess the current status of the abscess and any changes within the abdominal cavity. The imaging reveals that the abscess has expanded to 3 cm in diameter and there are signs of free air in the peritoneal cavity, confirming perforation. These results underscore the need for an urgent intervention. The team debates the merits of immediate surgical exploration versus proceeding with percutaneous drainage, weighing the risks of surgery against the potential for further sepsis and deterioration. As the patient's condition continues to evolve, the healthcare team remains vigilant, ready to adjust the treatment plan based on the patient's response and emerging clinical findings.

Section 3

As the healthcare team deliberates on the best course of action, they decide to proceed with percutaneous drainage of the abscess as an initial step, given the patient's stable blood pressure and the potential to mitigate immediate risks associated with open surgery. The procedure is performed under ultrasound guidance, and approximately 50 mL of purulent material is successfully aspirated, providing relief from some of the abdominal distension. Post-procedure, the patient's vital signs are closely monitored. His heart rate decreases slightly to 100 beats per minute, and his temperature drops to 38.3°C (100.9°F), indicating a partial response to the drainage and ongoing antibiotic therapy.

However, within the next 12 hours, the patient begins to experience increased respiratory distress. His respiratory rate climbs to 28 breaths per minute, and his oxygen saturation decreases to 90% on room air. Arterial blood gas analysis reveals a pH of 7.32, bicarbonate level of 18 mmol/L, and a pCO2 of 32 mmHg, confirming a state of metabolic acidosis with partial respiratory compensation. These findings suggest that the patient's condition may be complicated by a systemic inflammatory response or the onset of acute respiratory distress syndrome (ARDS), likely secondary to sepsis.

Recognizing the gravity of the situation, the healthcare team escalates care by increasing supplemental oxygen and starting a non-invasive ventilation trial to support the patient's respiratory function. Concurrently, broad-spectrum antibiotics are adjusted based on sensitivity patterns from the aspirated fluid cultures. The team remains vigilant, carefully monitoring for signs of further deterioration or improvement, and prepares for the possibility of escalating to invasive mechanical ventilation should the patient's respiratory status fail to stabilize. As the patient’s condition evolves, the team stands ready to reassess and adapt their management strategy, acknowledging the dynamic nature of his clinical picture and the potential for further complications.

Section 4

As the patient's respiratory status remains tenuous, the healthcare team reevaluates his condition, concentrating on potential new complications. During the next shift, the patient begins to exhibit signs of decreased urine output, with a measured urine output of 15 mL/hour over the past three hours. His blood pressure remains stable, albeit on the lower side of normal at 102/68 mmHg, while his heart rate remains elevated at 104 beats per minute. Recognizing the risk of developing acute kidney injury (AKI), particularly in the context of sepsis and potential fluid shifts, the team orders renal function tests and a complete metabolic panel.

The lab results show a rising creatinine level of 2.1 mg/dL from a baseline of 0.9 mg/dL and a blood urea nitrogen (BUN) of 32 mg/dL, indicating a significant decline in renal function. Electrolyte imbalances are also noted, with a potassium level of 5.8 mmol/L and sodium at 132 mmol/L. These findings, combined with the patient's metabolic acidosis and ongoing respiratory distress, suggest a multi-organ involvement, further complicating his clinical course. In response, the team initiates cautious fluid resuscitation with isotonic saline to improve renal perfusion while carefully monitoring for signs of fluid overload given the respiratory compromise.

The patient's deteriorating renal function prompts an interdisciplinary discussion to optimize the management strategy, considering the delicate balance between addressing organ dysfunction and supporting overall hemodynamic stability. The nephrology team is consulted for further evaluation and recommendations, including the potential need for renal replacement therapy should the patient's renal status continue to decline. Throughout this process, the healthcare team remains focused on frequent reassessments and dynamic adjustments to the treatment plan, understanding that the patient's condition could evolve rapidly, necessitating swift and informed clinical decisions.

Section 5

As the healthcare team continues to address the patient's evolving condition, a change in his status becomes apparent. Despite the initiation of cautious fluid resuscitation, the patient's urine output remains low, now averaging 10 mL/hour, and his respiratory status shows signs of further compromise. The patient's respiratory rate increases to 28 breaths per minute, and his oxygen saturation drops to 88% on 4 liters of nasal cannula oxygen. Auscultation of the lungs reveals new bilateral crackles, raising concerns about fluid overload. These developments prompt an immediate reassessment of the patient's fluid balance and respiratory support.

The team decides to transition the patient to a high-flow nasal cannula to improve oxygenation and support ventilation. Meanwhile, laboratory results indicate worsening metabolic acidosis, with an arterial blood gas showing a pH of 7.28 and a bicarbonate level of 18 mmol/L. The patient's potassium level remains elevated at 6.2 mmol/L, increasing the risk for cardiac complications. This electrolyte imbalance is addressed with a calcium gluconate infusion to stabilize cardiac membranes and insulin with glucose to facilitate intracellular potassium shift.

Given the patient's deteriorating status, the nephrology team recommends initiation of continuous renal replacement therapy (CRRT) to manage fluid overload and correct electrolyte imbalances more effectively. The interdisciplinary team acknowledges the complexity of managing the patient's multi-organ involvement and continues to closely monitor his hemodynamics, respiratory function, and renal status. The plan includes regular evaluations to adjust the treatment strategy, emphasizing the need for a dynamic and responsive approach to care as the patient's condition remains precarious.