Disturbed Sleep Pattern - Nursing Case Study

Pathophysiology

• Primary mechanism: Altered neurotransmitter balance affects sleep-wake cycles, with increased arousal-promoting neurotransmitters like norepinephrine and decreased sleep-promoting ones like serotonin and GABA, disrupting normal sleep architecture.

• Secondary mechanism: Circadian rhythm disruptions, often caused by irregular light exposure or shift work, lead to misalignment between the body's internal clock and external environment, impairing the ability to initiate and maintain sleep.

• Key complication: Chronic sleep pattern disturbances can exacerbate stress and immune dysfunction, increasing the risk for cardiovascular diseases and impairing cognitive function, which may affect daily activities and overall quality of life.

Patient Profile

Demographics:

42-year-old female, freelance graphic designer

History:

• Key past medical history: Generalized Anxiety Disorder, Mild Hypertension

• Current medications: Sertraline 50 mg daily, Hydrochlorothiazide 12.5 mg daily

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Difficulty sleeping for the past three months

• Key symptoms: Frequent awakenings during the night, daytime fatigue, irritability, difficulty concentrating

• Vital signs: Blood pressure 150/95 mmHg, Heart rate 98 bpm, Respiratory rate 20 breaths per minute, Temperature 98.6°F

Section 1

After the initial assessment, the patient, Ms. Harper, was advised to implement sleep hygiene practices and was referred to a sleep specialist for further evaluation. Despite these efforts, Ms. Harper returns two weeks later with worsening symptoms. She reports an increase in nighttime awakenings to four or five times per night, as well as vivid and distressing dreams. Her daytime fatigue has intensified, and she now experiences palpitations during periods of anxiety. A follow-up evaluation reveals persistently elevated blood pressure at 160/100 mmHg and a heart rate of 105 bpm. Her body mass index (BMI) remains within normal limits, but she notes a recent decrease in appetite.

A polysomnography study conducted by the sleep specialist highlights the presence of sleep apnea episodes, with an apnea-hypopnea index (AHI) of 15, indicating moderate sleep apnea. This new diagnostic finding suggests a potential exacerbation of her sleep disturbances, likely contributing to her elevated blood pressure and increased anxiety symptoms. The sleep apnea episodes are believed to be influencing her overall cardiovascular risk and cognitive function, given the repeated nocturnal hypoxemia and fragmented sleep.

The emergence of sleep apnea as a complication in Ms. Harper's case necessitates a multidisciplinary approach. The primary care provider coordinates with the sleep specialist to initiate continuous positive airway pressure (CPAP) therapy. Additionally, a cardiology consult is sought to address her resistant hypertension and assess potential cardiac sequelae. As Ms. Harper begins CPAP therapy, close monitoring of her blood pressure and anxiety symptoms is critical to evaluate the effectiveness of the interventions and to adjust her treatment plan accordingly. This development will guide further clinical reasoning regarding the interplay between her sleep disorder, anxiety management, and cardiovascular health.

Section 2

Two weeks after initiating CPAP therapy, Ms. Harper returns for a follow-up appointment. During this visit, she reports a noticeable improvement in the quality of her sleep, with a reduction in nighttime awakenings to one or two times per night. Her vivid dreams have become less frequent, and she experiences fewer episodes of daytime fatigue. However, she still feels tired in the afternoons and occasionally experiences palpitations, though they are less frequent. Her vital signs show a slight improvement, with blood pressure reading at 150/95 mmHg and a heart rate of 98 bpm. Despite the positive changes, Ms. Harper's anxiety levels remain elevated, particularly concerning her cardiovascular health.

A recent 24-hour ambulatory blood pressure monitoring indicates episodes of nocturnal hypertension, suggesting that while CPAP therapy has contributed to stabilizing her blood pressure during the day, nighttime control remains suboptimal. Laboratory tests reveal normal thyroid function and electrolytes, but a slight increase in her LDL cholesterol levels at 135 mg/dL, hinting at potential dyslipidemia. These findings suggest that while the CPAP therapy is addressing the sleep apnea effectively, additional interventions may be necessary to manage her anxiety and cardiovascular risks comprehensively.

The healthcare team considers the need for pharmacological intervention to manage Ms. Harper's resistant hypertension and anxiety. A low-dose beta-blocker is proposed to address both her elevated blood pressure and anxiety-related palpitations. Concurrently, Ms. Harper is encouraged to continue lifestyle modifications, including regular physical activity and dietary changes, to further support cardiovascular health. The cardiologist recommends reevaluating her lipid profile in three months to monitor any changes in response to these interventions. This multidisciplinary approach aims to provide a holistic management plan for Ms. Harper, addressing the interconnected nature of her sleep disorder, anxiety, and cardiovascular health.

Section 3

Three months after implementing the new management plan, Ms. Harper returns for a follow-up appointment. She reports feeling more energetic in the afternoons and notes that her anxiety levels have decreased significantly since starting the low-dose beta-blocker. Her palpitations have subsided, and she has experienced fewer episodes of nocturnal hypertension. A new set of vital signs reveals a further improvement in her blood pressure, now reading 140/90 mmHg, and her heart rate is steady at 85 bpm. These changes suggest a positive response to both pharmacological and lifestyle interventions.

To evaluate the effectiveness of her lipid management, a repeat lipid profile is conducted. The results indicate a slight reduction in her LDL cholesterol, now at 125 mg/dL, which, while an improvement, still signals a need for ongoing dietary vigilance and possibly an adjustment in her management plan. Additionally, her weight has decreased by 5 pounds, likely due to increased physical activity and adherence to dietary changes, supporting the overall cardiovascular health strategy.

Despite these improvements, Ms. Harper reports a new challenge: she experiences occasional episodes of dizziness, particularly when standing up quickly. This new symptom raises concerns about the possibility of orthostatic hypotension, potentially related to the beta-blocker therapy. The healthcare team decides to conduct an orthostatic blood pressure assessment to determine if adjustments to her medication regimen are necessary. This new development requires careful clinical reasoning to balance the benefits of the current interventions with the management of emerging side effects, guiding the next steps in Ms. Harper's treatment journey.

Section 4

The healthcare team proceeds with an orthostatic blood pressure assessment to evaluate the possibility of orthostatic hypotension as a result of the beta-blocker therapy. The initial findings reveal that Ms. Harper's blood pressure drops from 140/90 mmHg while sitting to 115/75 mmHg upon standing, with a corresponding increase in her heart rate to 98 bpm. These results confirm the presence of orthostatic hypotension, likely due to the vasodilatory effects of the beta-blocker. Despite this, Ms. Harper's cardiovascular health improvements are encouraging, and this new challenge necessitates a thoughtful reassessment of her current medication regimen.

The healthcare team considers the risk-benefit ratio of continuing the beta-blocker at its current dose. Given the positive impact on her anxiety, palpitations, and blood pressure, abrupt discontinuation is not advisable. Instead, the team evaluates alternative strategies, such as a gradual dose reduction or the introduction of a different antihypertensive class with a lower propensity for causing orthostatic changes. Collaboration with a pharmacist helps identify potential modifications, ensuring Ms. Harper's treatment maintains its efficacy while minimizing adverse effects. Additionally, lifestyle interventions, such as advising Ms. Harper to rise slowly from seated positions and stay adequately hydrated, are reinforced to mitigate the dizziness episodes.

This development prompts further diagnostic evaluations to rule out other contributing factors, such as electrolyte imbalances or dehydration, which could exacerbate orthostatic hypotension. A comprehensive metabolic panel is ordered, and the results show that Ms. Harper's sodium and potassium levels are within normal ranges, further supporting the adjustment of her pharmacological regimen as the primary intervention. As the team navigates this complication, the focus remains on optimizing Ms. Harper's overall treatment plan to sustain her positive trajectory while addressing the new symptoms effectively. This balanced approach aims to enhance her quality of life and prevent future complications, setting the stage for her continued journey towards improved health.

Section 5

As Ms. Harper continues her treatment, the healthcare team closely monitors her response to the adjusted medication regimen. A gradual reduction in her beta-blocker dose is implemented, accompanied by the introduction of a calcium channel blocker, which offers antihypertensive benefits with a lower risk of causing orthostatic hypotension. Over the next week, Ms. Harper reports a noticeable decrease in dizziness episodes, and her standing blood pressure stabilizes at 125/80 mmHg with a heart rate of 85 bpm. This improvement indicates that the new combination therapy is effectively managing her symptoms while maintaining cardiovascular stability.

However, during a routine follow-up, Ms. Harper mentions experiencing increased fatigue and mild swelling in her lower extremities. Concerned about potential fluid retention, the healthcare team conducts a focused assessment. Her vital signs remain stable, with a blood pressure of 130/85 mmHg and a heart rate of 88 bpm, but physical examination reveals mild pitting edema in her ankles. An echocardiogram is ordered to evaluate cardiac function, and it shows mild left ventricular hypertrophy, which may be contributing to her symptoms.

These findings prompt the team to consider additional strategies to address her fluid balance. Diuretic therapy is initiated at a low dose to manage the edema while monitoring electrolyte levels closely to prevent imbalances. The team also emphasizes the importance of dietary modifications, such as reducing sodium intake, to further alleviate fluid retention. Ms. Harper's active engagement in her treatment plan and the team's collaborative approach are crucial in addressing this new complication, ensuring her continued progress towards improved health and well-being. The healthcare team remains vigilant, ready to adapt the management plan as necessary to optimize Ms. Harper's quality of life and prevent further complications.