Hypertension - Nursing Case Study

Pathophysiology

• Primary mechanism: Increased systemic vascular resistance is a critical factor in hypertension, often due to chronic constriction of blood vessels. This can result from overactivity of the sympathetic nervous system, leading to persistent narrowing of the vessels and increased blood pressure.

• Secondary mechanism: Renin-angiotensin-aldosterone system (RAAS) dysfunction contributes significantly. Overproduction of renin by the kidneys leads to excessive angiotensin II, a potent vasoconstrictor, and increased aldosterone secretion, promoting sodium and water retention, thus elevating blood volume and pressure.

• Key complication: If uncontrolled, hypertension can cause damage to vital organs, such as the heart, kidneys, and brain. This can lead to conditions like heart failure, chronic kidney disease, and stroke, highlighting the importance of management and monitoring in clinical practice.

Patient Profile

Demographics:

55-year-old male, truck driver

History:

• Key past medical history: Hypertension diagnosed 5 years ago, borderline type 2 diabetes, smoker for 20 years (quit 2 years ago)

• Current medications: Lisinopril 20 mg daily, Metformin 500 mg twice daily, Aspirin 81 mg daily

• Allergies: Penicillin

Current Presentation:

• Chief complaint: Persistent headaches and dizziness

• Key symptoms: Fatigue, blurred vision, mild chest discomfort, occasional palpitations

• Vital signs: Blood pressure 160/100 mmHg, heart rate 92 bpm, respiratory rate 18 breaths per minute, temperature 98.6°F, BMI 31

Section 1

New Diagnostic Results:

Following the initial assessment, the healthcare team decided to proceed with further diagnostic tests to investigate the underlying causes of the patient's symptoms. Blood tests revealed elevated fasting glucose levels at 130 mg/dL, indicating poorly controlled blood sugar, and an increased HbA1c of 7.2%, suggesting that his borderline type 2 diabetes is progressing. Serum creatinine levels were slightly elevated at 1.4 mg/dL, pointing towards potential early-stage renal impairment. Additionally, lipid profile results showed elevated LDL cholesterol at 160 mg/dL and triglycerides at 200 mg/dL, both of which are risk factors for cardiovascular disease. These findings correlate with the patient's history of hypertension and obesity, further complicating his cardiovascular risk profile.

A 12-lead ECG was performed, and the results indicated left ventricular hypertrophy, a common complication of prolonged hypertension due to increased workload on the heart. This finding raises concern for potential progression towards heart failure if his blood pressure and other cardiovascular risk factors are not adequately controlled. An echocardiogram was recommended to assess the structural and functional changes in the heart more comprehensively.

These diagnostic results underscore the need for a holistic approach to managing the patient's condition. The interplay between hypertension, diabetes, and possible renal impairment requires careful adjustment of his current treatment regimen. There is a need for enhanced blood pressure control, tighter glycemic management, and lifestyle modifications, including diet and exercise, to mitigate further complications. The healthcare team plans to discuss these findings with the patient and explore potential adjustments to his medication regimen, such as the addition of a diuretic or a statin, to address his cardiovascular risk factors comprehensively.

Section 2

Change in Patient Status:

Following the discussion of the diagnostic results, the healthcare team initiated a revised treatment plan aimed at addressing the patient’s multiple cardiovascular risk factors. The patient was started on a low-dose diuretic to enhance blood pressure control and a statin to manage his elevated LDL cholesterol. These changes, alongside reinforced dietary and lifestyle modifications, were communicated clearly to the patient, emphasizing the importance of adherence to prevent further complications. However, during a follow-up appointment two weeks later, the patient reported feeling increasingly fatigued and experiencing episodes of dizziness, particularly when standing up quickly.

A thorough assessment was conducted to determine the cause of these new symptoms. The patient's blood pressure, measured at 110/70 mmHg, was lower than his previous readings, suggesting that the newly prescribed regimen was effective but might need adjusting to prevent hypotensive episodes. Additionally, his blood glucose levels remained elevated despite dietary efforts, with a fasting glucose of 126 mg/dL, indicating that his glycemic control still needed improvement. The healthcare team considered the possibility that the diuretic might be contributing to his dizziness due to volume depletion, prompting a review of his fluid intake and potential need for medication adjustment.

In light of these developments, the healthcare team decided to closely monitor the patient’s response to the medication adjustments and consider introducing an ACE inhibitor to better manage his hypertension and offer renal protection, given the slight elevation in creatinine levels. The patient was educated on recognizing signs of hypotension and encouraged to maintain adequate hydration. This approach aimed to balance blood pressure control without compromising the patient’s renal function or causing undue side effects, illustrating the complexity of managing comorbid conditions in the context of hypertension. The next steps would involve frequent follow-ups to assess the effectiveness of the interventions and adjust the treatment plan accordingly.

Section 3

Following the adjustment of the patient’s medication regimen and the introduction of an ACE inhibitor, the healthcare team scheduled a follow-up appointment for further evaluation. During this visit, the patient reported a decrease in the frequency of dizziness episodes, suggesting some initial positive response to the medication changes. However, he also mentioned experiencing a persistent dry cough, a well-documented side effect of ACE inhibitors, which was affecting his sleep quality and overall comfort. Vital signs taken during the assessment indicated a blood pressure of 115/75 mmHg and a heart rate of 78 bpm, both within an acceptable range but slightly lower than his baseline, which required careful monitoring to avoid hypotensive risks.

Laboratory tests were conducted to evaluate the patient's renal function and metabolic status. The results showed a slight improvement in LDL cholesterol levels, suggesting the statin was effective. However, his fasting glucose level remained elevated at 130 mg/dL, indicating that glycemic control was still an area of concern. Serum creatinine levels were stable, but the presence of proteinuria in the urine analysis raised concerns about potential renal involvement, highlighting the importance of preventing further renal damage given his cardiovascular risk factors.

In response to these findings, the healthcare team discussed the potential need to switch the patient from an ACE inhibitor to an angiotensin receptor blocker (ARB) to alleviate the cough while still providing cardiovascular and renal protection. Additionally, they considered the introduction of a medication specifically targeting blood glucose control, possibly a metformin regimen, to address the patient's persistent hyperglycemia. The patient was advised on lifestyle modifications, including dietary adjustments and exercise, to complement pharmacological interventions. The plan was to continue monitoring the patient closely, with a focus on minimizing side effects and optimizing the management of his comorbid conditions, thereby preventing further complications.

Section 4

The healthcare team decided to transition the patient from an ACE inhibitor to an angiotensin receptor blocker (ARB) to address the persistent dry cough. Within two weeks of this medication change, the patient reported substantial relief from the cough, resulting in improved sleep quality and overall comfort. During a follow-up visit, his blood pressure measured 120/80 mmHg with a heart rate of 76 bpm, indicating stable hemodynamics without signs of hypotension. Concurrently, the introduction of metformin was initiated to better manage his elevated fasting glucose levels. After four weeks on the new regimen, his fasting glucose decreased to 115 mg/dL, reflecting a positive trend toward improved glycemic control. However, the patient's urine analysis continued to show proteinuria, prompting further investigation into his renal function.

To address the ongoing proteinuria and assess potential renal complications, a renal ultrasound was performed, revealing mild bilateral renal parenchymal changes suggestive of early nephropathy. The healthcare team emphasized the importance of aggressive management of the patient's hypertension and diabetes to mitigate further renal damage. Dietary consultations were reinforced, focusing on a low-sodium, renal-friendly diet along with regular physical activity tailored to his abilities. The patient expressed motivation to adhere to these lifestyle changes, understanding their role in preventing progression to more severe renal disease.

Despite these positive adjustments, the patient reported intermittent episodes of mild ankle edema, a potential side effect associated with ARB therapy. The healthcare team decided to monitor this symptom closely, considering further diuretics if it worsened. They also planned regular follow-ups to evaluate the efficacy of the interventions and adjust the treatment plan as necessary, ensuring a comprehensive approach to managing his hypertension, diabetes, and emerging renal issues. This proactive strategy aimed to optimize the patient's overall health and prevent the development of more severe complications.

Section 5

Two months into the revised treatment regimen, the patient returned for a routine follow-up. Recent laboratory tests indicated a slight increase in serum creatinine to 1.4 mg/dL from a previous 1.2 mg/dL, alongside a new onset of microalbuminuria with albumin levels at 150 mg/g creatinine. These findings suggested a progression of renal impairment, prompting the healthcare team to re-evaluate the patient's current management plan. Despite these concerning lab results, the patient's blood pressure remained well-controlled at 118/78 mmHg, and his fasting glucose continued to improve, now consistently below 110 mg/dL.

During the physical assessment, the nurse noted a subtle increase in the severity of the ankle edema, now extending to the lower calves, which seemed more pronounced by the end of the day. The patient reported no significant changes in weight or diet but mentioned feeling slightly fatigued during his daily activities, attributing it to his efforts to increase physical exercise. Given these developments, the healthcare team decided to introduce a low-dose thiazide diuretic to address the edema and reassess the patient's renal function more frequently. A referral to a nephrologist was also considered to provide specialized care in managing the emerging renal complications.

The patient was counseled on the importance of maintaining strict adherence to his medication regimen and dietary guidelines, with an emphasis on avoiding nephrotoxic agents and staying well-hydrated. The team also scheduled a follow-up renal panel and urine analysis in four weeks to closely monitor any further changes in renal function. This comprehensive and proactive approach aimed to stabilize the patient's condition and prevent further deterioration of kidney health, while continuously evaluating the effectiveness of the current therapeutic interventions.