fever - Nursing Case Study
Pathophysiology
• Primary mechanism: The hypothalamus, the body's thermostat, is reset to a higher temperature in response to pyrogens (fever-inducing substances). These can be exogenous, like bacterial toxins, or endogenous, like cytokines (e.g., interleukin-1, tumor necrosis factor) released by immune cells during infection.
• Secondary mechanism: Prostaglandins, particularly E2 (PGE2), are produced in the hypothalamus as a result of pyrogen activity. PGE2 increases the hypothalamic set point, leading to physiological responses such as vasoconstriction and shivering to raise body temperature.
• Key complication: Sustained high fever can lead to increased metabolic demand and potential organ damage, particularly in vulnerable populations such as children and the elderly. Fever management aims to alleviate symptoms and prevent these complications.
Patient Profile
Demographics:
32-year-old female, office manager
History:
• Key past medical history: Hypertension, seasonal allergies
• Current medications: Lisinopril 10 mg daily, Loratadine 10 mg as needed
• Allergies: Penicillin
Current Presentation:
• Chief complaint: Persistent fever for the past 4 days
• Key symptoms: Headache, muscle aches, chills, fatigue, cough
• Vital signs: Temperature 101.8°F, Blood pressure 138/90 mmHg, Heart rate 104 bpm, Respiratory rate 22 breaths per minute, Oxygen saturation 95% on room air
Section 1
As the care team continues to monitor the patient, they notice a change in her clinical status that requires immediate attention. On the fifth day of her persistent fever, the patient begins to exhibit increasing respiratory distress, evidenced by an elevated respiratory rate of 28 breaths per minute and a drop in her oxygen saturation to 92% on room air. Auscultation of her lungs reveals crackles in the right lower lobe, suggesting the possibility of a developing pulmonary complication, such as pneumonia. Despite her initial presentation with a dry cough, it has now progressed to a productive cough with yellow-green sputum, further raising the suspicion of a bacterial respiratory infection.
Laboratory results reveal a white blood cell count of 15,000/mm³, indicative of a leukocytosis consistent with an infectious process. Additionally, a chest X-ray is performed, which confirms the presence of an infiltrate in the right lower lobe, supporting the diagnosis of community-acquired pneumonia. Blood cultures are ordered to identify the causative organism, but empirical antibiotic therapy is initiated promptly to cover common pathogens, taking into account her penicillin allergy.
This change in the patient's condition and the new diagnostic findings provide an opportunity for clinical reasoning, as the care team must consider the impact of the pneumonia on her fever and overall health. The decision to start antibiotics empirically, considering her allergy, demonstrates the need for careful selection of a suitable alternative such as a macrolide or respiratory fluoroquinolone. The team must also reassess her current medications, as the addition of new treatments could interact with her existing antihypertensive and allergy medications. The priority now is to manage her infection effectively while monitoring for further complications, such as sepsis or worsening respiratory function, which could significantly affect her recovery.
Section 2
As the care team continues to manage the patient, they closely monitor her response to the empirical antibiotic therapy. On the second day of treatment, her fever remains elevated at 101.5°F, and she reports feeling more fatigued than before. Her respiratory distress has slightly worsened, with her respiratory rate increasing to 32 breaths per minute, and her oxygen saturation dropping further to 90% on room air. In response, supplemental oxygen is administered via nasal cannula at 2 liters per minute to stabilize her oxygen levels. Repeat auscultation of the lungs reveals more pronounced crackles, now extending to the middle lobe of the right lung, suggesting the possibility of worsening pneumonia or the development of a secondary bacterial infection.
New laboratory results indicate that her white blood cell count has climbed to 17,500/mm³, and her C-reactive protein levels have significantly increased, both indicative of ongoing inflammation and infection. The blood cultures have returned, identifying Streptococcus pneumoniae as the causative organism, which is resistant to the initially chosen macrolide antibiotic. Given her penicillin allergy, the care team deliberates on adjusting her antibiotic regimen to a respiratory fluoroquinolone, such as levofloxacin, to more effectively target the resistant strain.
In light of these developments, the care team must exercise clinical reasoning to adjust the treatment plan, considering both the progression of her pneumonia and the new antibiotic choice. The potential for further complications, such as sepsis, remains a concern, necessitating vigilant monitoring of her vital signs, renal function, and any signs of systemic deterioration. The team must also evaluate the patient's fluid status to prevent fluid overload, which could exacerbate her respiratory condition. These decisions will guide the next phase of her care, aiming to achieve clinical stability and prevent further complications.
Section 3
As the care team implements the new antibiotic regimen with levofloxacin, they continue to closely monitor the patient's response and overall condition. By the third day of treatment, there is a noticeable change in her status. Although her fever has slightly decreased to 100.8°F, her respiratory status remains concerning. Despite the supplemental oxygen, her oxygen saturation fluctuates between 88% and 91%, prompting an increase in oxygen delivery to 4 liters per minute via nasal cannula. The patient's respiratory rate persists at an elevated 30 breaths per minute, and auscultation reveals coarse crackles now present in both lower lobes, suggesting bilateral involvement and a potential progression of her pneumonia.
In addition to respiratory symptoms, the patient begins to exhibit signs suggestive of potential fluid imbalance. She reports a new onset of peripheral edema in her lower extremities, and her daily fluid intake-output chart indicates a positive fluid balance, raising concerns about fluid overload. Her blood pressure has also increased to 150/95 mmHg, and there is a slight reduction in her urine output, with her creatinine levels trending upwards from 1.0 mg/dL to 1.3 mg/dL over 24 hours. These findings necessitate a reassessment of her fluid management strategy, balancing the need for hydration with the risk of exacerbating her respiratory distress.
In response to these developments, the care team must engage in careful clinical reasoning to adjust her treatment plan. This includes considering diuretic therapy to address possible fluid overload while ensuring that her renal function is not further compromised. Continuous monitoring of her vital signs, respiratory status, and renal function will be crucial to detect any early signs of systemic deterioration, such as sepsis or acute kidney injury. The team must also re-evaluate her nutritional status to support her recovery, as her increased fatigue and potential for fluid retention could impact her overall energy levels and immune response. These considerations will guide the next steps in her management, with the goal of stabilizing her condition and preventing further complications.
Section 4
On the fourth day of treatment, the care team receives new diagnostic results that provide further insight into the patient's condition. A repeat chest X-ray indicates worsening bilateral infiltrates, confirming a progression of her pneumonia. Additionally, a recent sputum culture reveals the presence of a multidrug-resistant strain of Pseudomonas aeruginosa, which may explain the suboptimal response to the current antibiotic regimen. The team promptly consults with an infectious disease specialist to adjust the antibiotic therapy, considering options like piperacillin-tazobactam or meropenem to target the resistant organism effectively.
Simultaneously, laboratory tests reveal additional challenges. The patient's white blood cell count has risen to 16,000/mm³, indicating a possible systemic inflammatory response. Her C-reactive protein (CRP) level has similarly increased, further suggesting an escalation in her inflammatory status. Despite the initiation of diuretic therapy to manage her fluid overload, her creatinine level continues to climb, now reaching 1.5 mg/dL, raising concerns about impending acute kidney injury. These findings necessitate a delicate balance in her fluid management to prevent further renal compromise while addressing her respiratory difficulties.
In light of these developments, the care team emphasizes the importance of continuous multidisciplinary collaboration. They implement a more aggressive respiratory therapy regimen, including the possible use of non-invasive ventilation to stabilize her oxygenation. The patient's nutritional needs are reassessed, with plans to initiate a high-calorie, high-protein diet to support her immune function and energy requirements. This comprehensive approach aims to address the multifaceted nature of her condition, with ongoing adjustments based on her evolving clinical status.
Section 5
In the following 48 hours, the care team meticulously monitors the patient's response to the adjusted antibiotic regimen and intensified respiratory support. Initially, there are promising signs; her oxygen saturation improves to 94% on the non-invasive ventilation, indicating better gas exchange. However, the situation soon becomes more complex when the patient starts to exhibit signs of increased respiratory effort, with a respiratory rate climbing to 28 breaths per minute and use of accessory muscles becoming evident. Auscultation reveals diminished breath sounds with coarse crackles bilaterally, suggesting persistent fluid accumulation and potentially worsening pulmonary edema.
Concurrently, the patient begins to exhibit neurological changes that raise red flags for the team. She becomes increasingly lethargic and confused, with a fluctuating level of consciousness that complicates her ability to participate in her care. Her Glasgow Coma Scale (GCS) score drops to 13, prompting urgent reevaluation of her mental status. A repeat set of laboratory tests reveals a notable drop in her serum sodium to 128 mmol/L, indicating hyponatremia, which may be contributing to her altered mental state. The team considers the possibility of syndrome of inappropriate antidiuretic hormone secretion (SIADH) as a complication of her pneumonia or as an adverse effect of her ongoing treatment.
These developments necessitate immediate adjustments to her care plan. The team decides to initiate a fluid restriction protocol to correct her sodium imbalance while carefully monitoring her renal function, given her rising creatinine levels. Additionally, they prioritize further neurological assessment and potential imaging to rule out other causes of her altered mental status, such as central nervous system infection or ischemic events. This nuanced approach underscores the importance of dynamic assessment and intervention as the patient's condition continues to evolve, with the care team poised to adapt their strategies to address emerging complications effectively.